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Protein Dynamics

Hytönen lab

Publications

Accepted manuscripts not available elsewhere (pdf files)

2024

  1. Kedari, A, Iheozor-Ejiofor, R, Salminen, P, Uğurlu, H, Mäkelä, AR, Levanov, L et al.. Structural insight into rabies virus neutralization revealed by an engineered antibody scaffold. Structure. 2024;32 (12):2220-2230.e4. doi: 10.1016/j.str.2024.10.002. PubMed PMID:39471803 .
  2. Lampinen, V, Ojanen, MJT, Caro, FM, Gröhn, S, Hankaniemi, MM, Pesu, M et al.. Experimental VLP vaccine displaying a furin antigen elicits production of autoantibodies and is well tolerated in mice. Nanoscale Adv. 2024;6 (24):6239-52. doi: 10.1039/d4na00483c. PubMed PMID:39430302 PubMed Central PMC11485048.
  3. Wang, X, Baster, Z, Azizi, L, Li, L, Rajfur, Z, Hytönen, VP et al.. Talin2 binds to non-muscle myosin IIa and regulates cell attachment and fibronectin secretion. Sci Rep. 2024;14 (1):20175. doi: 10.1038/s41598-024-70866-w. PubMed PMID:39215026 PubMed Central PMC11364542.
  4. Turkki, P, Chowdhury, I, Öhman, T, Azizi, L, Varjosalo, M, Hytönen, VP et al.. Tensin-2 interactomics reveals interaction with GAPDH and a phosphorylation-mediated regulatory role in glycolysis. Sci Rep. 2024;14 (1):19862. doi: 10.1038/s41598-024-65787-7. PubMed PMID:39191795 PubMed Central PMC11350193.
  5. Azizi, L, Otani, Y, Mykuliak, VV, Goult, BT, Hytönen, VP, Turkki, P et al.. Talin-1 variants associated with spontaneous coronary artery dissection (SCAD) highlight how even subtle changes in multi-functional scaffold proteins can manifest in disease. Hum Mol Genet. 2024;33 (21):1846-1857. doi: 10.1093/hmg/ddae120. PubMed PMID:39163585 PubMed Central PMC11540920.
  6. Bizaki-Vallaskangas, A, Rämö, J, Sliz, E, Kivekäs, I, Willberg, T, Saarentaus, E et al.. Genome-wide association study indicates novel associations of annexin A13 to secretory and GAS2L2 with mucous otitis media. Sci Rep. 2024;14 (1):18344. doi: 10.1038/s41598-024-68781-1. PubMed PMID:39112560 PubMed Central PMC11306868.
  7. Mykuliak, VV, Rahikainen, R, Ball, NJ, Bussi, G, Goult, BT, Hytönen, VP et al.. Molecular dynamics simulations reveal how vinculin refolds partially unfolded talin rod helices to stabilize them against mechanical force. PLoS Comput Biol. 2024;20 (8):e1012341. doi: 10.1371/journal.pcbi.1012341. PubMed PMID:39110765 PubMed Central PMC11333002.
  8. Lampinen, V, Gröhn, S, Lehmler, N, Jartti, M, Hytönen, VP, Schubert, M et al.. Production of norovirus-, rotavirus-, and enterovirus-like particles in insect cells is simplified by plasmid-based expression. Sci Rep. 2024;14 (1):14874. doi: 10.1038/s41598-024-65316-6. PubMed PMID:38937523 PubMed Central PMC11211442.
  9. Sidibé, A, Mykuliak, VV, Zhang, P, Hytönen, VP, Wu, J, Wehrle-Haller, B et al.. Acetyl-NPKY of integrin-β1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity. iScience. 2024;27 (6):110129. doi: 10.1016/j.isci.2024.110129. PubMed PMID:38904068 PubMed Central PMC11187247.
  10. Leclerc, S, Gupta, A, Ruokolainen, V, Chen, JH, Kunnas, K, Ekman, AA et al.. Progression of herpesvirus infection remodels mitochondrial organization and metabolism. PLoS Pathog. 2024;20 (4):e1011829. doi: 10.1371/journal.ppat.1011829. PubMed PMID:38620036 PubMed Central PMC11045090.

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2023
  1. Rahikainen, R, Vester, SK, Turkki, P, Janosko, CP, Deiters, A, Hytönen, VP et al.. Visible Light-Induced Specific Protein Reaction Delineates Early Stages of Cell Adhesion. J Am Chem Soc. 2023;145 (45):24459-24465. doi: 10.1021/jacs.3c07827. PubMed PMID:38104267 PubMed Central PMC10655181.
  2. Patrakka, O, Tuomisto, S, Pienimäki, JP, Ollikainen, J, Oksala, N, Lampinen, V et al.. Thrombus Aspirates From Patients With Acute Ischemic Stroke Are Infiltrated by Viridans Streptococci. J Am Heart Assoc. 2023;12 (22):e030639. doi: 10.1161/JAHA.123.030639. PubMed PMID:37982253 PubMed Central PMC10727284.
  3. Rahikainen, R, Vester, SK, Turkki, P, Janosko, CP, Deiters, A, Hytönen, VP et al.. Visible light-induced specific protein reaction delineates early stages of cell adhesion. bioRxiv. 2023; :. doi: 10.1101/2023.07.21.549850. PubMed PMID:37503248 PubMed Central PMC10370186.
  4. Seitz, I, Saarinen, S, Kumpula, EP, McNeale, D, Anaya-Plaza, E, Lampinen, V et al.. DNA-origami-directed virus capsid polymorphism. Nat Nanotechnol. 2023;18 (10):1205-1212. doi: 10.1038/s41565-023-01443-x. PubMed PMID:37460794 PubMed Central PMC10575778.
  5. Lampinen, V, Gröhn, S, Soppela, S, Blazevic, V, Hytönen, VP, Hankaniemi, MM et al.. SpyTag/SpyCatcher display of influenza M2e peptide on norovirus-like particle provides stronger immunization than direct genetic fusion. Front Cell Infect Microbiol. 2023;13 :1216364. doi: 10.3389/fcimb.2023.1216364. PubMed PMID:37424789 PubMed Central PMC10323135.
  6. Bachmann, M, Su, B, Rahikainen, R, Hytönen, VP, Wu, J, Wehrle-Haller, B et al.. ConFERMing the role of talin in integrin activation and mechanosignaling. J Cell Sci. 2023;136 (8):. doi: 10.1242/jcs.260576. PubMed PMID:37078342 PubMed Central PMC10198623.
  7. Pavic, K, Gupta, N, Omella, JD, Derua, R, Aakula, A, Huhtaniemi, R et al.. Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A. Nat Commun. 2023;14 (1):1143. doi: 10.1038/s41467-023-36693-9. PubMed PMID:36854761 PubMed Central PMC9974998.
  8. Kerkhoff, Y, Azizi, L, Mykuliak, VV, Hytönen, VP, Block, S. Microfluidics-Based Force Spectroscopy Enables High-Throughput Force Experiments with Sub-Nanometer Resolution and Sub-Piconewton Sensitivity. Small. 2023;19 (14):e2206713. doi: 10.1002/smll.202206713. PubMed PMID:36631276 .

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2022
  1. Goult, BT, von Essen, M, Hytönen, VP. The mechanical cell – the role of force dependencies in synchronising protein interaction networks. J Cell Sci. 2022;135 (22):. doi: 10.1242/jcs.259769. PubMed PMID:36398718 PubMed Central PMC9845749.
  2. Stone, VM, Utorova, R, Butrym, M, Sioofy-Khojine, AB, Hankaniemi, MM, Ringqvist, EE et al.. Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination. iScience. 2022;25 (10):105070. doi: 10.1016/j.isci.2022.105070. PubMed PMID:36157581 PubMed Central PMC9490033.
  3. Yrjänäinen, A, Patrikainen, MS, Azizi, L, Tolvanen, MEE, Laitaoja, M, Jänis, J et al.. Biochemical and Biophysical Characterization of Carbonic Anhydrase VI from Human Milk and Saliva. Protein J. 2022;41 (4-5):489-503. doi: 10.1007/s10930-022-10070-9. PubMed PMID:35947329 PubMed Central PMC9464147.
  4. Azizi, L, Varela, L, Turkki, P, Mykuliak, VV, Korpela, S, Ihalainen, TO et al.. Talin variant P229S compromises integrin activation and associates with multifaceted clinical symptoms. Hum Mol Genet. 2022;31 (24):4159-4172. doi: 10.1093/hmg/ddac163. PubMed PMID:35861643 PubMed Central PMC9759328.
  5. Zolfaghari Emameh, R, Barker, HR, Turpeinen, H, Parkkila, S, Hytönen, VP. A reverse vaccinology approach on transmembrane carbonic anhydrases from Plasmodium species as vaccine candidates for malaria prevention. Malar J. 2022;21 (1):189. doi: 10.1186/s12936-022-04186-7. PubMed PMID:35706028PubMed Central PMC9199335.
  6. Urbański, LJ, Bua, S, Angeli, A, Emameh, RZ, Barker, HR, Kuuslahti, M et al.. The production and biochemical characterization of α-carbonic anhydrase from Lactobacillus rhamnosus GG. Appl Microbiol Biotechnol. 2022;106 (11):4065-4074. doi: 10.1007/s00253-022-11990-3. PubMed PMID:35612631PubMed Central PMC9200688.
  7. Kopra, K, Hassan, N, Vuorinen, E, Valtonen, S, Mahran, R, Habib, H et al.. Rapid high-throughput compatible label-free virus particle quantification method based on time-resolved luminescence. Anal Bioanal Chem. 2022;414 (15):4509-4518. doi: 10.1007/s00216-022-04104-5. PubMed PMID:35581427PubMed Central PMC9113738.
  8. Piesanen, J, Valjakka, J, Niemelä, S, Borgenström, M, Nikkari, S, Hytönen, V et al.. Hepcidin is potential regulator for renin activity. PLoS One. 2022;17 (4):e0267343. doi: 10.1371/journal.pone.0267343. PubMed PMID:35442992 PubMed Central PMC9020709.
  9. Lindfors, L, Sioris, P, Anttalainen, A, Korelin, K, Kontunen, A, Karjalainen, M et al.. Detection of cultured breast cancer cells from human tumor-derived matrix by differential ion mobility spectrometry. Anal Chim Acta. 2022;1202 :339659. doi: 10.1016/j.aca.2022.339659. PubMed PMID:35341512 .
  10. Heinimäki, S, Lampinen, V, Tamminen, K, Hankaniemi, MM, Malm, M, Hytönen, VP et al.. Antigenicity and immunogenicity of HA2 and M2e influenza virus antigens conjugated to norovirus-like, VP1 capsid-based particles by the SpyTag/SpyCatcher technology. Virology. 2022;566 :89-97. doi: 10.1016/j.virol.2021.12.001. PubMed PMID:34894525 .
  11. Urbański, LJ, Angeli, A, Mykuliak, VV, Azizi, L, Kuuslahti, M, Hytönen, VP et al.. Biochemical and structural characterization of beta-carbonic anhydrase from the parasite Trichomonas vaginalis. J Mol Med (Berl). 2022;100 (1):115-124. doi: 10.1007/s00109-021-02148-1. PubMed PMID:34652457 PubMed Central PMC8724216.

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2021
  1. Heinimäki, S, Lampinen, V, Tamminen, K, Hankaniemi, MM, Malm, M, Hytönen, VP et al.. Antigenicity and immunogenicity of HA2 and M2e influenza virus antigens conjugated to norovirus-like, VP1 capsid-based particles by the SpyTag/SpyCatcher technology. Virology. 2022;566 :89-97. doi: 10.1016/j.virol.2021.12.001. PubMed PMID:34894525 .
  2. Urbański, LJ, Angeli, A, Mykuliak, VV, Azizi, L, Kuuslahti, M, Hytönen, VP et al.. Biochemical and structural characterization of beta-carbonic anhydrase from the parasite Trichomonas vaginalis. J Mol Med (Berl). 2022;100 (1):115-124. doi: 10.1007/s00109-021-02148-1. PubMed PMID:34652457 PubMed Central PMC8724216.
  3. Leppiniemi, J, Mutahir, Z, Dulebo, A, Mikkonen, P, Nuopponen, M, Turkki, P et al.. Avidin-Conjugated Nanofibrillar Cellulose Hydrogel Functionalized with Biotinylated Fibronectin and Vitronectin Promotes 3D Culture of Fibroblasts. Biomacromolecules. 2021;22 (10):4122-4137. doi: 10.1021/acs.biomac.1c00579. PubMed PMID:34542997 .
  4. Azizi, L, Turkki, P, Huynh, N, Massera, JM, Hytönen, VP. Surface Modification of Bioactive Glass Promotes Cell Attachment and Spreading. ACS Omega. 2021;6 (35):22635-22642. doi: 10.1021/acsomega.1c02669. PubMed PMID:34514235 PubMed Central PMC8427643.
  5. Stone, VM, Butrym, M, Hankaniemi, MM, Sioofy-Khojine, AB, Hytönen, VP, Hyöty, H et al.. Coxsackievirus B Vaccines Prevent Infection-Accelerated Diabetes in NOD Mice and Have No Disease-Inducing Effect. Diabetes. 2021;70 (12):2871-2878. doi: 10.2337/db21-0193. PubMed PMID:34497136 PubMed Central PMC8660981.
  6. Reshamwala, D, Shroff, S, Sheik Amamuddy, O, Laquintana, V, Denora, N, Zacheo, A et al.. Polyphenols Epigallocatechin Gallate and Resveratrol, and Polyphenol-Functionalized Nanoparticles Prevent Enterovirus Infection through Clustering and Stabilization of the Viruses. Pharmaceutics. 2021;13 (8):. doi: 10.3390/pharmaceutics13081182. PubMed PMID:34452144 PubMed Central PMC8398301.
  7. Hyunh, NB, Palma, CSD, Rahikainen, R, Mishra, A, Azizi, L, Verne, E et al.. Surface Modification of Bioresorbable Phosphate Glasses for Controlled Protein Adsorption. ACS Biomater Sci Eng. 2021;7 (9):4483-4493. doi: 10.1021/acsbiomaterials.1c00735. PubMed PMID:34382772 PubMed Central PMC8441970.
  8. Multamäki, E, Nanekar, R, Morozov, D, Lievonen, T, Golonka, D, Wahlgren, WY et al.. Comparative analysis of two paradigm bacteriophytochromes reveals opposite functionalities in two-component signaling. Nat Commun. 2021;12 (1):4394. doi: 10.1038/s41467-021-24676-7. PubMed PMID:34285211 PubMed Central PMC8292422.
  9. Laitinen, OH, Kuusela, TP, Kukkurainen, S, Nurminen, A, Sinkkonen, A, Hytönen, VP et al.. Bacterial avidins are a widely distributed protein family in Actinobacteria, Proteobacteria and Bacteroidetes. BMC Ecol Evol. 2021;21 (1):53. doi: 10.1186/s12862-021-01784-y. PubMed PMID:33836663 PubMed Central PMC8033661.
  10. Ripamonti, M, Liaudet, N, Azizi, L, Bouvard, D, Hytönen, VP, Wehrle-Haller, B et al.. Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions. Commun Biol. 2021;4 (1):380. doi: 10.1038/s42003-021-01886-9. PubMed PMID:33782527PubMed Central PMC8007706.
  11. Angeli, A, Urbański, LJ, Hytönen, VP, Parkkila, S, Supuran, CT. Activation of the β-carbonic anhydrase from the protozoan pathogen with amines and amino acids. J Enzyme Inhib Med Chem. 2021;36 (1):758-763. doi: 10.1080/14756366.2021.1897802. PubMed PMID:33715570 PubMed Central PMC7952076.
  12. Lampinen, V, Heinimäki, S, Laitinen, OH, Pesu, M, Hankaniemi, MM, Blazevic, V et al.. Modular vaccine platform based on the norovirus-like particle. J Nanobiotechnology. 2021;19 (1):25. doi: 10.1186/s12951-021-00772-0. PubMed PMID:33468139 PubMed Central PMC7815183.
  13. Rasheed, A, Azizi, L, Turkki, P, Janka, M, Hytönen, VP, Tuukkanen, S et al.. Extrusion-Based Bioprinting of Multilayered Nanocellulose Constructs for Cell Cultivation Using Freezing and Preprint CaCl Cross-Linking. ACS Omega. 2021;6 (1):569-578. doi: 10.1021/acsomega.0c05036. PubMed PMID:33458509 PubMed Central PMC7807796.
  14. Azizi, L, Cowell, AR, Mykuliak, VV, Goult, BT, Turkki, P, Hytönen, VP et al.. Cancer associated talin point mutations disorganise cell adhesion and migration. Sci Rep. 2021;11 (1):347. doi: 10.1038/s41598-020-77911-4. PubMed PMID:33431906 PubMed Central PMC7801617.
  15. Urbański, LJ, Angeli, A, Hytönen, VP, Di Fiore, A, De Simone, G, Parkkila, S et al.. Inhibition of the β-carbonic anhydrase from the protozoan pathogen with sulphonamides. J Enzyme Inhib Med Chem. 2021;36 (1):329-334. doi: 10.1080/14756366.2020.1863958. PubMed PMID:33356653 PubMed Central PMC7782162.
  16. Gunnarsson, A, Stubbs, CJ, Rawlins, PB, Taylor-Newman, E, Lee, WC, Geschwindner, S et al.. Regenerable Biosensors for Small-Molecule Kinetic Characterization Using SPR. SLAS Discov. 2021;26 (5):730-739. doi: 10.1177/2472555220975358. PubMed PMID:33289457 .

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2020
  1. Rasheed, A, Azizi, L, Turkki, P, Janka, M, Hytönen, VP, Tuukkanen, S et al.. Extrusion-Based Bioprinting of Multilayered Nanocellulose Constructs for Cell Cultivation Using Freezing and Preprint CaCl Cross-Linking. ACS Omega. 2021;6 (1):569-578. doi: 10.1021/acsomega.0c05036. PubMed PMID:33458509 PubMed Central PMC7807796.
  2. Gunnarsson, A, Stubbs, CJ, Rawlins, PB, Taylor-Newman, E, Lee, WC, Geschwindner, S et al.. Regenerable Biosensors for Small-Molecule Kinetic Characterization Using SPR. SLAS Discov. 2021;26 (5):730-739. doi: 10.1177/2472555220975358. PubMed PMID:33289457 .
  3. Zhang, P, Azizi, L, Kukkurainen, S, Gao, T, Baikoghli, M, Jacquier, MC et al.. Crystal structure of the FERM-folded talin head reveals the determinants for integrin binding. Proc Natl Acad Sci U S A. 2020;117 (51):32402-32412. doi: 10.1073/pnas.2014583117. PubMed PMID:33288722 PubMed Central PMC7768682.
  4. Urbański, LJ, Angeli, A, Hytönen, VP, Di Fiore, A, Parkkila, S, De Simone, G et al.. Inhibition of the newly discovered β‑carbonic anhydrase from the protozoan pathogen Trichomonas vaginalis with inorganic anions and small molecules. J Inorg Biochem. 2020;213 :111274. doi: 10.1016/j.jinorgbio.2020.111274. PubMed PMID:33068968 .
  5. Kukkurainen, S, Azizi, L, Zhang, P, Jacquier, MC, Baikoghli, M, von Essen, M et al.. The F1 loop of the talin head domain acts as a gatekeeper in integrin activation and clustering. J Cell Sci. 2020;133 (19):. doi: 10.1242/jcs.239202. PubMed PMID:33046605 PubMed Central PMC10679385.
  6. Urbanski, LJ, Bua, S, Angeli, A, Kuuslahti, M, Hytönen, VP, Supuran, CT et al.. Sulphonamide inhibition profile of β-carbonic anhydrase. J Enzyme Inhib Med Chem. 2020;35 (1):1834-1839. doi: 10.1080/14756366.2020.1826942. PubMed PMID:32972256 PubMed Central PMC7534311.
  7. Saarinen, NVV, Lehtonen, J, Veijola, R, Lempainen, J, Knip, M, Hyöty, H et al.. Correction: Saarinen, N.V.V., et al. Multiplexed High-Throughput Serological Assay for Human Enteroviruses. 2020, , 963. Microorganisms. 2020;8 (9):. doi: 10.3390/microorganisms8091426. PubMed PMID:32957450 PubMed Central PMC7563745.
  8. Hankaniemi, MM, Baikoghli, MA, Stone, VM, Xing, L, Väätäinen, O, Soppela, S et al.. Structural Insight into CVB3-VLP Non-Adjuvanted Vaccine. Microorganisms. 2020;8 (9):. doi: 10.3390/microorganisms8091287. PubMed PMID:32846899 PubMed Central PMC7565060.
  9. Mykuliak, VV, Sikora, M, Booth, JJ, Cieplak, M, Shalashilin, DV, Hytönen, VP et al.. Mechanical Unfolding of Proteins-A Comparative Nonequilibrium Molecular Dynamics Study. Biophys J. 2020;119 (5):939-949. doi: 10.1016/j.bpj.2020.07.030. PubMed PMID:32822586 PubMed Central PMC7474207.
  10. Vasala, A, Hytönen, VP, Laitinen, OH. Modern Tools for Rapid Diagnostics of Antimicrobial Resistance. Front Cell Infect Microbiol. 2020;10 :308. doi: 10.3389/fcimb.2020.00308. PubMed PMID:32760676PubMed Central PMC7373752.
  11. Heinimäki, S, Tamminen, K, Hytönen, VP, Malm, M, Blazevic, V. Rotavirus Inner Capsid VP6 Acts as an Adjuvant in Formulations with Particulate Antigens Only. Vaccines (Basel). 2020;8 (3):. doi: 10.3390/vaccines8030365. PubMed PMID:32645976 PubMed Central PMC7565724.
  12. Saarinen, NVV, Lehtonen, J, Veijola, R, Lempainen, J, Knip, M, Hyöty, H et al.. Multiplexed High-Throughput Serological Assay for Human Enteroviruses. Microorganisms. 2020;8 (6):. doi: 10.3390/microorganisms8060963. PubMed PMID:32604930 PubMed Central PMC7355947.
  13. Urbański, LJ, Di Fiore, A, Azizi, L, Hytönen, VP, Kuuslahti, M, Buonanno, M et al.. Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase from . J Enzyme Inhib Med Chem. 2020;35 (1):1292-1299. doi: 10.1080/14756366.2020.1774572. PubMed PMID:32515610 PubMed Central PMC7717681.
  14. Bachmann, M, Schäfer, M, Mykuliak, VV, Ripamonti, M, Heiser, L, Weißenbruch, K et al.. Induction of ligand promiscuity of αVβ3 integrin by mechanical force. J Cell Sci. 2020;133 (9):. doi: 10.1242/jcs.242404. PubMed PMID:32193334 .
  15. Hytönen, VP. (Strept)avidin as a template for ligands other than biotin: An overview. Methods Enzymol. 2020;633 :21-28. doi: 10.1016/bs.mie.2019.10.029. PubMed PMID:32046847 .
  16. Oberbichler, E, Wiesauer, M, Schlögl, E, Stangl, J, Faschinger, F, Knör, G et al.. Competitive binding assay for biotin and biotin derivatives, based on avidin and biotin-4-fluorescein. Methods Enzymol. 2020;633 :1-20. doi: 10.1016/bs.mie.2019.10.028. PubMed PMID:32046840 .
  17. Saarinen, NVV, Stone, VM, Hankaniemi, MM, Mazur, MA, Vuorinen, T, Flodström-Tullberg, M et al.. Antibody Responses against Enterovirus Proteases are Potential Markers for an Acute Infection. Viruses. 2020;12 (1):. doi: 10.3390/v12010078. PubMed PMID:31936473 PubMed Central PMC7020046.
  18. Baster, Z, Li, L, Kukkurainen, S, Chen, J, Pentikäinen, O, Győrffy, B et al.. Cyanidin-3-glucoside binds to talin and modulates colon cancer cell adhesions and 3D growth. FASEB J. 2020;34 (2):2227-2237. doi: 10.1096/fj.201900945R. PubMed PMID:31916632 .
  19. Chronopoulos, A, Thorpe, SD, Cortes, E, Lachowski, D, Rice, AJ, Mykuliak, VV et al.. Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway. Nat Mater. 2020;19 (6):669-678. doi: 10.1038/s41563-019-0567-1. PubMed PMID:31907416 PubMed Central PMC7260055.

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2019
  1. Hytönen, VP. (Strept)avidin as a template for ligands other than biotin: An overview. Methods Enzymol. 2020;633 :21-28. doi: 10.1016/bs.mie.2019.10.029. PubMed PMID:32046847 .
  2. Oberbichler, E, Wiesauer, M, Schlögl, E, Stangl, J, Faschinger, F, Knör, G et al.. Competitive binding assay for biotin and biotin derivatives, based on avidin and biotin-4-fluorescein. Methods Enzymol. 2020;633 :1-20. doi: 10.1016/bs.mie.2019.10.028. PubMed PMID:32046840 .
  3. Keeble, AH, Turkki, P, Stokes, S, Khairil Anuar, INA, Rahikainen, R, Hytönen, VP et al.. Approaching infinite affinity through engineering of peptide-protein interaction. Proc Natl Acad Sci U S A. 2019; :. doi: 10.1073/pnas.1909653116. PubMed PMID:31822621 PubMed Central PMC6936558.
  4. Laajala, M, Hankaniemi, MM, Määttä, JAE, Hytönen, VP, Laitinen, OH, Marjomäki, V et al.. Host Cell Calpains Can Cleave Structural Proteins from the Enterovirus Polyprotein. Viruses. 2019;11 (12):. doi: 10.3390/v11121106. PubMed PMID:31795245 PubMed Central PMC6950447.
  5. Heinimäki, S, Hankaniemi, MM, Sioofy-Khojine, AB, Laitinen, OH, Hyöty, H, Hytönen, VP et al.. Combination of three virus-derived nanoparticles as a vaccine against enteric pathogens; enterovirus, norovirus and rotavirus. Vaccine. 2019;37 (51):7509-7518. doi: 10.1016/j.vaccine.2019.09.072. PubMed PMID:31585726 .
  6. Parveen, N, Rydell, GE, Larson, G, Hytönen, VP, Zhdanov, VP, Höök, F et al.. Competition for Membrane Receptors: Norovirus Detachment via Lectin Attachment. J Am Chem Soc. 2019;141 (41):16303-16311. doi: 10.1021/jacs.9b06036. PubMed PMID:31533424 .
  7. Hankaniemi, MM, Stone, VM, Andrejeff, T, Heinimäki, S, Sioofy-Khojine, AB, Marjomäki, V et al.. Formalin treatment increases the stability and immunogenicity of coxsackievirus B1 VLP vaccine. Antiviral Res. 2019;171 :104595. doi: 10.1016/j.antiviral.2019.104595. PubMed PMID:31491431 .
  8. Hankaniemi, MM, Stone, VM, Sioofy-Khojine, AB, Heinimäki, S, Marjomäki, V, Hyöty, H et al.. A comparative study of the effect of UV and formalin inactivation on the stability and immunogenicity of a Coxsackievirus B1 vaccine. Vaccine. 2019;37 (40):5962-5971. doi: 10.1016/j.vaccine.2019.08.037. PubMed PMID:31471148 .
  9. Gering, C, Koivisto, JT, Parraga, J, Leppiniemi, J, Vuornos, K, Hytönen, VP et al.. Design of modular gellan gum hydrogel functionalized with avidin and biotinylated adhesive ligands for cell culture applications. PLoS One. 2019;14 (8):e0221931. doi: 10.1371/journal.pone.0221931. PubMed PMID:31469884PubMed Central PMC6716642.
  10. Bachmann, M, Kukkurainen, S, Hytönen, VP, Wehrle-Haller, B. Cell Adhesion by Integrins. Physiol Rev. 2019;99 (4):1655-1699. doi: 10.1152/physrev.00036.2018. PubMed PMID:31313981 .
  11. Lemma, T, Wang, J, Arstila, K, Hytönen, VP, Toppari, JJ. Identifying yeasts using surface enhanced Raman spectroscopy. Spectrochim Acta A Mol Biomol Spectrosc. 2019;218 :299-307. doi: 10.1016/j.saa.2019.04.010. PubMed PMID:31005737 .
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