2024
- Yrjänäinen, A, Mesiä, E, Lampela, E, Kreutzer, J, Vihinen, J, Tornberg, K et al.. Barrier-free, open-top microfluidic chip for generating two distinct, interconnected 3D microvascular networks. Sci Rep. 2024;14 (1):22916. doi: 10.1038/s41598-024-74493-3. PubMed PMID:39358415 .
- Szczodra, A, Houaoui, A, Agniel, R, Sicard, L, Miettinen, S, Massera, J et al.. Boron substitution in silicate bioactive glass scaffolds to enhance bone differentiation and regeneration. Acta Biomater. 2024;186 :489-506. doi: 10.1016/j.actbio.2024.07.053. PubMed PMID:39098444 .
- Vuorenpää, H, Valtonen, J, Penttinen, K, Koskimäki, S, Hovinen, E, Ahola, A et al.. Gellan gum-gelatin based cardiac models support formation of cellular networks and functional cardiomyocytes. Cytotechnology. 2024;76 (4):483-502. doi: 10.1007/s10616-024-00630-5. PubMed PMID:38933872 PubMed Central PMC11196475.
- Kurki, A, Paakinaho, K, Hannula, M, Karjalainen, S, Kuismanen, K, Hyttinen, J et al.. Promoting cell proliferation and collagen production with ascorbic acid 2-phosphate-releasing poly(l-lactide-co-ε-caprolactone) membranes for treating pelvic organ prolapse. Regen Biomater. 2024;11 :rbae060. doi: 10.1093/rb/rbae060. PubMed PMID:38903561 PubMed Central PMC11187500.
- Puistola, P, Kethiri, A, Nurminen, A, Turkki, J, Hopia, K, Miettinen, S et al.. Cornea-Specific Human Adipose Stem Cell-Derived Extracellular Matrix for Corneal Stroma Tissue Engineering. ACS Appl Mater Interfaces. 2024;16 (13):15761-15772. doi: 10.1021/acsami.3c17803. PubMed PMID:38513048 PubMed Central PMC10995904.
- Szczodra, A, Houaoui, A, Salminen, T, Hannula, M, Gobbo, VA, Ghanavati, S et al.. Pore graded borosilicate bioactive glass scaffolds: in vitro dissolution and cytocompatibility. J Mater Sci Mater Med. 2024;35 (1):17. doi: 10.1007/s10856-024-06791-1. PubMed PMID:38507150 PubMed Central PMC10954867.
- Mirzaie, M, Gholizadeh, E, Miettinen, JJ, Ianevski, F, Ruokoranta, T, Saarela, J et al.. Designing patient-oriented combination therapies for acute myeloid leukemia based on efficacy/toxicity integration and bipartite network modeling. Oncogenesis. 2024;13 (1):11. doi: 10.1038/s41389-024-00510-9. PubMed PMID:38429288 PubMed Central PMC10907624.
- Puistola, P, Miettinen, S, Skottman, H, Mörö, A. Novel strategy for multi-material 3D bioprinting of human stem cell based corneal stroma with heterogenous design. Mater Today Bio. 2024;24 :100924. doi: 10.1016/j.mtbio.2023.100924. PubMed PMID:38226015 PubMed Central PMC10788621.
- Chen, Y, He, L, Ianevski, A, Ayuda-Durán, P, Potdar, S, Saarela, J et al.. Robust scoring of selective drug responses for patient-tailored therapy selection. Nat Protoc. 2024;19 (1):60-82. doi: 10.1038/s41596-023-00903-x. PubMed PMID:37996540 .
- Sartoneva, R, Paakinaho, K, Hannula, M, Kuismanen, K, Huhtala, H, Hyttinen, J et al.. Ascorbic Acid 2-Phosphate Releasing Supercritically Foamed Porous Poly-L-Lactide-Co-ε-Caprolactone Scaffold Enhances the Collagen Production of Human Vaginal Stromal Cells: A New Approach for Vaginal Tissue Engineering. Tissue Eng Regen Med. 2024;21 (1):81-96. doi: 10.1007/s13770-023-00603-3. PubMed PMID:37907765 PubMed Central PMC10764701.
2023
- Suominen, S, Hyypijev, T, Venäläinen, M, Yrjänäinen, A, Vuorenpää, H, Lehti-Polojärvi, M et al.. Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell Cultures. Cells. 2023;12 (19):. doi: 10.3390/cells12192368. PubMed PMID:37830581 PubMed Central PMC10571736.
- Isosaari, L, Vuorenpää, H, Yrjänäinen, A, Kapucu, FE, Kelloniemi, M, Pakarinen, TK et al.. Simultaneous induction of vasculature and neuronal network formation on a chip reveals a dynamic interrelationship between cell types. Cell Commun Signal. 2023;21 (1):132. doi: 10.1186/s12964-023-01159-4. PubMed PMID:37316873 PubMed Central PMC10265920.
- Sartoneva, R, Lyyra, I, Juusela, M, Sharma, V, Huhtala, H, Massera, J et al.. In vitro biocompatibility of polylactide and polybutylene succinate blends for urethral tissue engineering. J Biomed Mater Res B Appl Biomater. 2023;111 (10):1728-1740. doi: 10.1002/jbm.b.35268. PubMed PMID:37199480 .
- Mahmoud, M, Juntunen, M, Adnan, A, Kummola, L, Junttila, IS, Kelloniemi, M et al.. Immunomodulatory Functions of Adipose Mesenchymal Stromal/Stem Cell Derived From Donors With Type 2 Diabetes and Obesity on CD4 T Cells. Stem Cells. 2023;41 (5):505-519. doi: 10.1093/stmcls/sxad021. PubMed PMID:36945068 PubMed Central PMC10183970.
- Hyväri, L, Vanhatupa, S, Ojansivu, M, Kelloniemi, M, Pakarinen, TK, Hupa, L et al.. Heat Shock Protein 27 Is Involved in the Bioactive Glass Induced Osteogenic Response of Human Mesenchymal Stem Cells. Cells. 2023;12 (2):. doi: 10.3390/cells12020224. PubMed PMID:36672159 PubMed Central PMC9856363.
2022
- Mörö, A, Samanta, S, Honkamäki, L, Rangasami, VK, Puistola, P, Kauppila, M et al.. Hyaluronic acid based next generation bioink for 3D bioprinting of human stem cell derived corneal stromal model with innervation. Biofabrication. 2022;15 (1):. doi: 10.1088/1758-5090/acab34. PubMed PMID:36579828 .
- Gering, C, Párraga, J, Vuorenpää, H, Botero, L, Miettinen, S, Kellomäki, M et al.. Bioactivated gellan gum hydrogels affect cellular rearrangement and cell response in vascular co-culture and subcutaneous implant models. Biomater Adv. 2022;143 :213185. doi: 10.1016/j.bioadv.2022.213185. PubMed PMID:36371972 .
- Koivunotko, E, Snirvi, J, Merivaara, A, Harjumäki, R, Rautiainen, S, Kelloniemi, M et al.. Angiogenic Potential of Human Adipose-Derived Mesenchymal Stromal Cells in Nanofibrillated Cellulose Hydrogel. Biomedicines. 2022;10 (10):. doi: 10.3390/biomedicines10102584. PubMed PMID:36289846 PubMed Central PMC9599553.
- Karttunen, J, Heiskanen, M, Joki, T, Hyysalo, A, Navarro-Ferrandis, V, Miettinen, S et al.. Effect of cell culture media on extracellular vesicle secretion from mesenchymal stromal cells and neurons. Eur J Cell Biol. 2022;101 (4):151270. doi: 10.1016/j.ejcb.2022.151270. PubMed PMID:35987046 .
- Gebraad, A, Ohlsbom, R, Miettinen, JJ, Emeh, P, Pakarinen, TK, Manninen, M et al.. Growth Response and Differentiation of Bone Marrow-Derived Mesenchymal Stem/Stromal Cells in the Presence of Novel Multiple Myeloma Drug Melflufen. Cells. 2022;11 (9):. doi: 10.3390/cells11091574. PubMed PMID:35563880 PubMed Central PMC9103864.
- Herbers, E, Patrikoski, M, Wagner, A, Jokinen, R, Hassinen, A, Heinonen, S et al.. Preventing White Adipocyte Browning during Differentiation : The Effect of Differentiation Protocols on Metabolic and Mitochondrial Phenotypes. Stem Cells Int. 2022;2022 :3308194. doi: 10.1155/2022/3308194. PubMed PMID:35422865 PubMed Central PMC9005291.
- Mykuliak, A, Yrjänäinen, A, Mäki, AJ, Gebraad, A, Lampela, E, Kääriäinen, M et al.. Vasculogenic Potency of Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells Results in Differing Vascular Network Phenotypes in a Microfluidic Chip. Front Bioeng Biotechnol. 2022;10 :764237. doi: 10.3389/fbioe.2022.764237. PubMed PMID:35211462 PubMed Central PMC8861308.
2021
- Juntunen, M, Heinonen, S, Huhtala, H, Rissanen, A, Kaprio, J, Kuismanen, K et al.. Evaluation of the effect of donor weight on adipose stromal/stem cell characteristics by using weight-discordant monozygotic twin pairs. Stem Cell Res Ther. 2021;12 (1):516. doi: 10.1186/s13287-021-02587-0. PubMed PMID:34565451 PubMed Central PMC8474937.
- Rangasami, VK, Nawale, G, Asawa, K, Kadekar, S, Samanta, S, Nilsson, B et al.. Pluronic Micelle-Mediated Tissue Factor Silencing Enhances Hemocompatibility, Stemness, Differentiation Potential, and Paracrine Signaling of Mesenchymal Stem Cells. Biomacromolecules. 2021;22 (5):1980-1989. doi: 10.1021/acs.biomac.1c00070. PubMed PMID:33813822 PubMed Central PMC8154246.
- Bakreen, A, Juntunen, M, Dunlop, Y, Ugidos, IF, Malm, T, Miettinen, S et al.. Additive Behavioral Improvement after Combined Cell Therapy and Rehabilitation Despite Long-Term Microglia Presence in Stroke Rats. Int J Mol Sci. 2021;22 (4):. doi: 10.3390/ijms22041512. PubMed PMID:33546370 PubMed Central PMC7913568.
2020
- Juntunen, M, Hagman, S, Moisan, A, Narkilahti, S, Miettinen, S. Oxygen-Glucose Deprivation-Induced Stroke Models with Human Neuroblastoma Cell- and Induced Pluripotent Stem Cell-Derived Neurons. Stem Cells Int. 2020;2020 :8841026. doi: 10.1155/2020/8841026. PubMed PMID:33178286 PubMed Central PMC7647751.
- Hyväri, L, Vanhatupa, S, Halonen, HT, Kääriäinen, M, Miettinen, S. Myocardin-Related Transcription Factor A (MRTF-A) Regulates the Balance between Adipogenesis and Osteogenesis of Human Adipose Stem Cells. Stem Cells Int. 2020;2020 :8853541. doi: 10.1155/2020/8853541. PubMed PMID:33029150 PubMed Central PMC7527895.
- Tamminen, I, Lehto, K, Hannula, M, Ojansivu, M, Johansson, L, Kellomäki, M et al.. A tube-source X-ray microtomography approach for quantitative 3D microscopy of optically challenging cell-cultured samples. Commun Biol. 2020;3 (1):548. doi: 10.1038/s42003-020-01273-w. PubMed PMID:33009501 PubMed Central PMC7532209.
- Palmroth, A, Salpavaara, T, Vuoristo, P, Karjalainen, S, Kääriäinen, T, Miettinen, S et al.. Materials and Orthopedic Applications for Bioresorbable Inductively Coupled Resonance Sensors. ACS Appl Mater Interfaces. 2020;12 (28):31148-31161. doi: 10.1021/acsami.0c07278. PubMed PMID:32568505 PubMed Central PMC7467565.
- Palmroth, A, Pitkänen, S, Hannula, M, Paakinaho, K, Hyttinen, J, Miettinen, S et al.. Evaluation of scaffold microstructure and comparison of cell seeding methods using micro-computed tomography-based tools. J R Soc Interface. 2020;17 (165):20200102. doi: 10.1098/rsif.2020.0102. PubMed PMID:32228403 PubMed Central PMC7211473.
- Calejo, MT, Saari, J, Vuorenpää, H, Vuorimaa-Laukkanen, E, Kallio, P, Aalto-Setälä, K et al.. Co-culture of human induced pluripotent stem cell-derived retinal pigment epithelial cells and endothelial cells on double collagen-coated honeycomb films. Acta Biomater. 2020;101 :327-343. doi: 10.1016/j.actbio.2019.11.002. PubMed PMID:31711900 .
- Vuornos, K, Huhtala, H, Kääriäinen, M, Kuismanen, K, Hupa, L, Kellomäki, M et al.. Bioactive glass ions for in vitro osteogenesis and microvascularization in gellan gum-collagen hydrogels. J Biomed Mater Res B Appl Biomater. 2020;108 (4):1332-1342. doi: 10.1002/jbm.b.34482. PubMed PMID:31471954 .
- Vanhatupa, S, Miettinen, S, Pena, P, Baudín, C. Diopside-tricalcium phosphate bioactive ceramics for osteogenic differentiation of human adipose stem cells. J Biomed Mater Res B Appl Biomater. 2020;108 (3):819-833. doi: 10.1002/jbm.b.34436. PubMed PMID:31251466 .
2019
- Calejo, MT, Saari, J, Vuorenpää, H, Vuorimaa-Laukkanen, E, Kallio, P, Aalto-Setälä, K et al.. Co-culture of human induced pluripotent stem cell-derived retinal pigment epithelial cells and endothelial cells on double collagen-coated honeycomb films. Acta Biomater. 2020;101 :327-343. doi: 10.1016/j.actbio.2019.11.002. PubMed PMID:31711900 .
- Koivusalo, L, Kauppila, M, Samanta, S, Parihar, VS, Ilmarinen, T, Miettinen, S et al.. Tissue adhesive hyaluronic acid hydrogels for sutureless stem cell delivery and regeneration of corneal epithelium and stroma. Biomaterials. 2019;225 :119516. doi: 10.1016/j.biomaterials.2019.119516. PubMed PMID:31574405 .
- Kiiskinen, J, Merivaara, A, Hakkarainen, T, Kääriäinen, M, Miettinen, S, Yliperttula, M et al.. Nanofibrillar cellulose wound dressing supports the growth and characteristics of human mesenchymal stem/stromal cells without cell adhesion coatings. Stem Cell Res Ther. 2019;10 (1):292. doi: 10.1186/s13287-019-1394-7. PubMed PMID:31547864 PubMed Central PMC6757411.
- Wang, X, Molino, BZ, Pitkänen, S, Ojansivu, M, Xu, C, Hannula, M et al.. 3D Scaffolds of Polycaprolactone/Copper-Doped Bioactive Glass: Architecture Engineering with Additive Manufacturing and Cellular Assessments in a Coculture of Bone Marrow Stem Cells and Endothelial Cells. ACS Biomater Sci Eng. 2019;5 (9):4496-4510. doi: 10.1021/acsbiomaterials.9b00105. PubMed PMID:33438415 .
- Vuornos, K, Huhtala, H, Kääriäinen, M, Kuismanen, K, Hupa, L, Kellomäki, M et al.. Bioactive glass ions for in vitro osteogenesis and microvascularization in gellan gum-collagen hydrogels. J Biomed Mater Res B Appl Biomater. 2020;108 (4):1332-1342. doi: 10.1002/jbm.b.34482. PubMed PMID:31471954 .
- Gering, C, Koivisto, JT, Parraga, J, Leppiniemi, J, Vuornos, K, Hytönen, VP et al.. Design of modular gellan gum hydrogel functionalized with avidin and biotinylated adhesive ligands for cell culture applications. PLoS One. 2019;14 (8):e0221931. doi: 10.1371/journal.pone.0221931. PubMed PMID:31469884 PubMed Central PMC6716642.
- Vanhatupa, S, Miettinen, S, Pena, P, Baudín, C. Diopside-tricalcium phosphate bioactive ceramics for osteogenic differentiation of human adipose stem cells. J Biomed Mater Res B Appl Biomater. 2020;108 (3):819-833. doi: 10.1002/jbm.b.34436. PubMed PMID:31251466 .
- Patrikoski, M, Mannerström, B, Miettinen, S. Perspectives for Clinical Translation of Adipose Stromal/Stem Cells. Stem Cells Int. 2019;2019 :5858247. doi: 10.1155/2019/5858247. PubMed PMID:31191677 PubMed Central PMC6525805.
- Mishra, A, Ojansivu, M, Autio, R, Vanhatupa, S, Miettinen, S, Massera, J et al.. In-vitro dissolution characteristics and human adipose stem cell response to novel borophosphate glasses. J Biomed Mater Res A. 2019;107 (9):2099-2114. doi: 10.1002/jbm.a.36722. PubMed PMID:31087776 .
- Mu, J, Bakreen, A, Juntunen, M, Korhonen, P, Oinonen, E, Cui, L et al.. Combined Adipose Tissue-Derived Mesenchymal Stem Cell Therapy and Rehabilitation in Experimental Stroke. Front Neurol. 2019;10 :235. doi: 10.3389/fneur.2019.00235. PubMed PMID:30972000 PubMed Central PMC6443824.
- Vuornos, K, Ojansivu, M, Koivisto, JT, Häkkänen, H, Belay, B, Montonen, T et al.. Bioactive glass ions induce efficient osteogenic differentiation of human adipose stem cells encapsulated in gellan gum and collagen type I hydrogels. Mater Sci Eng C Mater Biol Appl. 2019;99 :905-918. doi: 10.1016/j.msec.2019.02.035. PubMed PMID:30889765 .
- Ojansivu, M, Rashad, A, Ahlinder, A, Massera, J, Mishra, A, Syverud, K et al.. Wood-based nanocellulose and bioactive glass modified gelatin-alginate bioinks for 3D bioprinting of bone cells. Biofabrication. 2019;11 (3):035010. doi: 10.1088/1758-5090/ab0692. PubMed PMID:30754034 .
- Núñez-Toldrà, R, Montori, S, Bosch, B, Hupa, L, Atari, M, Miettinen, S et al.. S53P4 Bioactive Glass Inorganic Ions for Vascularized Bone Tissue Engineering by Dental Pulp Pluripotent-Like Stem Cell Cocultures. Tissue Eng Part A. 2019;25 (17-18):1213-1224. doi: 10.1089/ten.TEA.2018.0256. PubMed PMID:30612528 .
2018
- Hyväri, L, Ojansivu, M, Juntunen, M, Kartasalo, K, Miettinen, S, Vanhatupa, S et al.. Focal Adhesion Kinase and ROCK Signaling Are Switch-Like Regulators of Human Adipose Stem Cell Differentiation towards Osteogenic and Adipogenic Lineages. Stem Cells Int. 2018;2018 :2190657. doi: 10.1155/2018/2190657. PubMed PMID:30275837 PubMed Central PMC6157106.
- Sartoneva, R, Kuismanen, K, Juntunen, M, Karjalainen, S, Hannula, M, Kyllönen, L et al.. Porous poly-l-lactide-co-ɛ-caprolactone scaffold: a novel biomaterial for vaginal tissue engineering. R Soc Open Sci. 2018;5 (8):180811. doi: 10.1098/rsos.180811. PubMed PMID:30225072 PubMed Central PMC6124079.
- Ojansivu, M, Mishra, A, Vanhatupa, S, Juntunen, M, Larionova, A, Massera, J et al.. The effect of S53P4-based borosilicate glasses and glass dissolution products on the osteogenic commitment of human adipose stem cells. PLoS One. 2018;13 (8):e0202740. doi: 10.1371/journal.pone.0202740. PubMed PMID:30153295 PubMed Central PMC6112657.
- Ojansivu, M, Johansson, L, Vanhatupa, S, Tamminen, I, Hannula, M, Hyttinen, J et al.. Knitted 3D Scaffolds of Polybutylene Succinate Support Human Mesenchymal Stem Cell Growth and Osteogenesis. Stem Cells Int. 2018;2018 :5928935. doi: 10.1155/2018/5928935. PubMed PMID:29853915 PubMed Central PMC5964421.
- Gebraad, A, Kornilov, R, Kaur, S, Miettinen, S, Haimi, S, Peltoniemi, H et al.. Monocyte-derived extracellular vesicles stimulate cytokine secretion and gene expression of matrix metalloproteinases by mesenchymal stem/stromal cells. FEBS J. 2018;285 (12):2337-2359. doi: 10.1111/febs.14485. PubMed PMID:29732732 .
- Sorkio, A, Koch, L, Koivusalo, L, Deiwick, A, Miettinen, S, Chichkov, B et al.. Human stem cell based corneal tissue mimicking structures using laser-assisted 3D bioprinting and functional bioinks. Biomaterials. 2018;171 :57-71. doi: 10.1016/j.biomaterials.2018.04.034. PubMed PMID:29684677 .
- Koivusalo, L, Karvinen, J, Sorsa, E, Jönkkäri, I, Väliaho, J, Kallio, P et al.. Hydrazone crosslinked hyaluronan-based hydrogels for therapeutic delivery of adipose stem cells to treat corneal defects. Mater Sci Eng C Mater Biol Appl. 2018;85 :68-78. doi: 10.1016/j.msec.2017.12.013. PubMed PMID:29407158 .
- Kuismanen, K, Juntunen, M, Narra Girish, N, Tuominen, H, Huhtala, H, Nieminen, K et al.. Functional Outcome of Human Adipose Stem Cell Injections in Rat Anal Sphincter Acute Injury Model. Stem Cells Transl Med. 2018;7 (3):295-304. doi: 10.1002/sctm.17-0208. PubMed PMID:29383878 PubMed Central PMC5827744.
- Sartoneva, R, Nordback, PH, Haimi, S, Grijpma, DW, Lehto, K, Rooney, N et al.. Comparison of Poly(l-lactide-co-ɛ-caprolactone) and Poly(trimethylene carbonate) Membranes for Urethral Regeneration: An In Vitro and In Vivo Study. Tissue Eng Part A. 2018;24 (1-2):117-127. doi: 10.1089/ten.TEA.2016.0245. PubMed PMID:28463605 .