Stem cell applications

The light detecting cells, photoreceptors, are in tight contact with retinal pigment epithelial (RPE) cells that locate underneath them in the retina. The interaction between these tissues is essential for the vision, as RPE maintains the well-being of the photoreceptors with many important functions (such as secretion of growth factors, renewal of photoreceptor outer segments by phagocytosis and control of ion transportation and waste product removal). The focus of our research group is to understand better the role of RPE in healthy eye and in different eye diseases as well as the interaction between RPE and retina. For this we use human embryonic stem cell (hESC) and human induced pluripotent stem cell (hiPSC) -based RPE from healthy donors and patients with an eye disease. Additionally, the interaction of RPE and retina we study with biomaterials. These unique model systems offer us research with sufficient material and tools to reveal new essential knowledge on cellular mechanisms.




Korkka et al., 2022, Stem Cells Translational Medicine

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