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VACCIM

Research Center for Vaccine Development and Immunology

Publications

2024

  1. Nolan, T, Bhusal, C, Beran, J, Bloch, M, Cetin, BS, Dinleyici, EC et al.. Breadth of immune response, immunogenicity, reactogenicity, and safety for a pentavalent meningococcal ABCWY vaccine in healthy adolescents and young adults: results from a phase 3, randomised, controlled observer-blinded trial. Lancet Infect Dis. 2024; :. doi: 10.1016/S1473-3099(24)00667-4. PubMed PMID:39647494 .
  2. Loponen, J, Vähätalo, I, Tuomisto, LE, Niemelä, O, Lehtimäki, L, Hämäläinen, M et al.. Physical exercise, systemic inflammation and adult-onset asthma: a 12-year follow-up study. J Asthma. 2024; :1-15. doi: 10.1080/02770903.2024.2438096. PubMed PMID:39636329 .
  3. Savolainen, LE, Peltola, J, Hilla, R, Åman, T, Broas, M, Junttila, IS et al.. Clinical performance of two commercially available rapid antigen tests for influenza, RSV, and SARS-CoV-2 diagnostics. Microbiol Spectr. 2024; :e0163024. doi: 10.1128/spectrum.01630-24. PubMed PMID:39589150 .
  4. Hyöty, H, Laiho, JE, Virtanen, SM. Environmental Factors in Type 1 Diabetes. Cold Spring Harb Perspect Med. 2024; :. doi: 10.1101/cshperspect.a041590. PubMed PMID:39586629 .
  5. Nolan, T, Bhusal, C, Beran, J, Bloch, M, Cetin, BS, Dinleyici, EC et al.. 4CMenB Breadth of Immune Response, Immunogenicity, and Safety: Results From a Phase 3 Randomized, Controlled, Observer Blind Study in Adolescents and Young Adults. Open Forum Infect Dis. 2024;11 (11):ofae638. doi: 10.1093/ofid/ofae638. PubMed PMID:39582508 PubMed Central PMC11584413.
  6. Tavast, IM, Solismaa, A, Lyytikäinen, LP, Mononen, N, Moilanen, E, Hämäläinen, M et al.. Leptin and leptin receptor gene polymorphisms and depression treatment response. Acta Neuropsychiatr. 2024; :1-8. doi: 10.1017/neu.2024.43. PubMed PMID:39529327 .
  7. Lernmark, Å, Agardh, D, Akolkar, B, Gesualdo, P, Hagopian, WA, Haller, MJ et al.. Looking back at the TEDDY study: lessons and future directions. Nat Rev Endocrinol. 2024; :. doi: 10.1038/s41574-024-01045-0. PubMed PMID:39496810 .
  8. Kedari, A, Iheozor-Ejiofor, R, Salminen, P, Uğurlu, H, Mäkelä, AR, Levanov, L et al.. Structural insight into rabies virus neutralization revealed by an engineered antibody scaffold. Structure. 2024;32 (12):2220-2230.e4. doi: 10.1016/j.str.2024.10.002. PubMed PMID:39471803 .
  9. Eurén, A, Lynch, K, Lindfors, K, Parikh, H, Koletzko, S, Liu, E et al.. Risk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures. Sci Rep. 2024;14 (1):25463. doi: 10.1038/s41598-024-75496-w. PubMed PMID:39462122 PubMed Central PMC11567144.
  10. Lampinen, V, Ojanen, MJT, Caro, FM, Gröhn, S, Hankaniemi, MM, Pesu, M et al.. Experimental VLP vaccine displaying a furin antigen elicits production of autoantibodies and is well tolerated in mice. Nanoscale Adv. 2024;6 (24):6239-52. doi: 10.1039/d4na00483c. PubMed PMID:39430302 PubMed Central PMC11485048.
  11. Walsh, EE, Pérez Marc, G, Falsey, AR, Jiang, Q, Eiras, D, Patton, M et al.. RENOIR Trial – RSVpreF Vaccine Efficacy over Two Seasons. N Engl J Med. 2024;391 (15):1459-1460. doi: 10.1056/NEJMc2311560. PubMed PMID:39413383 .
  12. Suonsyrjä, N, Metso, S, Moilanen, E, Mustonen, J, Jaatinen, P, Pörsti, I et al.. Haemodynamics of hyperthyroidism: increased cardiac work and findings related to vasodilatation. Eur Thyroid J. 2024;13 (5):. doi: 10.1530/ETJ-24-0090. PubMed PMID:39356807 PubMed Central PMC11558968.
  13. Pemmari, A, Moilanen, E. Macrophage and chondrocyte phenotypes in inflammation. Basic Clin Pharmacol Toxicol. 2024;135 (5):537-549. doi: 10.1111/bcpt.14085. PubMed PMID:39319534 .
  14. Laiho, JE, Oikarinen, S, Morfopoulou, S, Oikarinen, M, Renner, A, Depledge, D et al.. Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes. medRxiv. 2024; :. doi: 10.1101/2024.09.11.24313112. PubMed PMID:39314969 PubMed Central PMC11419248.
  15. Parajuli, A, Mäkelä, I, Roslund, MI, Ringqvist, E, Manninen, J, Sun, Y et al.. Production, analysis, and safety assessment of a soil and plant-based natural material with microbiome- and immune-modulatory effects. Methods. 2024;231 :94-102. doi: 10.1016/j.ymeth.2024.09.011. PubMed PMID:39306218 .
  16. Pasanen, A, Karjalainen, MK, Korppi, M, Hallman, M, Rämet, M, Research Project FinnGen
    et al.. Genetic susceptibility to acute viral bronchiolitis. J Infect Dis. 2024; :. doi: 10.1093/infdis/jiae467. PubMed PMID:39299705 .
  17. Atomwise AIMS Program. Author Correction: AI is a viable alternative to high throughput screening: a 318-target study. Sci Rep. 2024;14 (1):21579. doi: 10.1038/s41598-024-70321-w. PubMed PMID:39284864 PubMed Central PMC11405665.
  18. Ojwang’, V, Nwaru, BI, Hanna-Mari, T, Heli, T, Kaila, M, Ahonen, S et al.. Early-pregnancy BMI, maternal gestational weight gain, and asthma and allergic diseases in children. Pediatr Allergy Immunol. 2024;35 (9):e14240. doi: 10.1111/pai.14240. PubMed PMID:39282918 .
  19. Virtanen, A, Spinelli, FR, Telliez, JB, O’Shea, JJ, Silvennoinen, O, Gadina, M et al.. JAK inhibitor selectivity: new opportunities, better drugs?. Nat Rev Rheumatol. 2024;20 (10):649-665. doi: 10.1038/s41584-024-01153-1. PubMed PMID:39251770 .
  20. Langley, JM, Nolan, TM, Rämet, M, Richmond, PC, Rosário Filho, N, Haazen, W et al.. A Phase 1/2a Study Evaluating Safety and Immunogenicity of Ad26.RSV.preF in RSV-seronegative Toddlers Aged 12-24 Months. Open Forum Infect Dis. 2024;11 (9):ofae453. doi: 10.1093/ofid/ofae453. PubMed PMID:39220658 PubMed Central PMC11365064.
  21. Wang, X, Baster, Z, Azizi, L, Li, L, Rajfur, Z, Hytönen, VP et al.. Talin2 binds to non-muscle myosin IIa and regulates cell attachment and fibronectin secretion. Sci Rep. 2024;14 (1):20175. doi: 10.1038/s41598-024-70866-w. PubMed PMID:39215026 PubMed Central PMC11364542.
  22. Turkki, P, Chowdhury, I, Öhman, T, Azizi, L, Varjosalo, M, Hytönen, VP et al.. Tensin-2 interactomics reveals interaction with GAPDH and a phosphorylation-mediated regulatory role in glycolysis. Sci Rep. 2024;14 (1):19862. doi: 10.1038/s41598-024-65787-7. PubMed PMID:39191795 PubMed Central PMC11350193.
  23. Azizi, L, Otani, Y, Mykuliak, VV, Goult, BT, Hytönen, VP, Turkki, P et al.. Talin-1 variants associated with spontaneous coronary artery dissection (SCAD) highlight how even subtle changes in multi-functional scaffold proteins can manifest in disease. Hum Mol Genet. 2024;33 (21):1846-1857. doi: 10.1093/hmg/ddae120. PubMed PMID:39163585 PubMed Central PMC11540920.
  24. Sallomy, C, Awolade, P, Rahnasto-Rilla, M, Hämäläinen, M, Nousiainen, LP, Johansson, NG et al.. TRPA1 Inhibition Effects by 3-Phenylcoumarin Derivatives. ACS Med Chem Lett. 2024;15 (8):1221-1226. doi: 10.1021/acsmedchemlett.4c00072. PubMed PMID:39140042 PubMed Central PMC11318103.
  25. Tiensuu, H, Haapalainen, AM, Tissarinen, P, Pasanen, A, Hallman, M, Rämet, M et al.. MicroRNA expression profile in the basal plate of human placenta associates with spontaneous preterm birth. Placenta. 2024;155 :60-69. doi: 10.1016/j.placenta.2024.08.004. PubMed PMID:39137705 .
  26. Roslund, MI, Nurminen, N, Oikarinen, S, Puhakka, R, Grönroos, M, Puustinen, L et al.. Skin exposure to soil microbiota elicits changes in cell-mediated immunity to pneumococcal vaccine. Sci Rep. 2024;14 (1):18573. doi: 10.1038/s41598-024-68235-8. PubMed PMID:39127736 PubMed Central PMC11316737.
  27. Bizaki-Vallaskangas, A, Rämö, J, Sliz, E, Kivekäs, I, Willberg, T, Saarentaus, E et al.. Genome-wide association study indicates novel associations of annexin A13 to secretory and GAS2L2 with mucous otitis media. Sci Rep. 2024;14 (1):18344. doi: 10.1038/s41598-024-68781-1. PubMed PMID:39112560 PubMed Central PMC11306868.
  28. Mykuliak, VV, Rahikainen, R, Ball, NJ, Bussi, G, Goult, BT, Hytönen, VP et al.. Molecular dynamics simulations reveal how vinculin refolds partially unfolded talin rod helices to stabilize them against mechanical force. PLoS Comput Biol. 2024;20 (8):e1012341. doi: 10.1371/journal.pcbi.1012341. PubMed PMID:39110765 PubMed Central PMC11333002.
  29. Clark, R, Davies, S, Labrador, J, Loubet, P, Natalini Martínez, S, Moríñigo, HM et al.. Safety and Immunogenicity of Respiratory Syncytial Virus Prefusion F Protein Vaccine when Co-administered with Adjuvanted Seasonal Quadrivalent Influenza Vaccine in Older Adults: A Phase 3 Randomized Trial. Clin Infect Dis. 2024;79 (4):1088-1098. doi: 10.1093/cid/ciae365. PubMed PMID:39099085 PubMed Central PMC11478588.
  30. Marttila, S, Rajić, S, Ciantar, J, Mak, JKL, Junttila, IS, Kummola, L et al.. Biological aging of different blood cell types. Geroscience. 2024; :. doi: 10.1007/s11357-024-01287-w. PubMed PMID:39060678 .
  31. Jartti, M, Flodström-Tullberg, M, Hankaniemi, MM. Enteroviruses: epidemic potential, challenges and opportunities with vaccines. J Biomed Sci. 2024;31 (1):73. doi: 10.1186/s12929-024-01058-x. PubMed PMID:39010093 PubMed Central PMC11247760.
  32. Ryyti, R, Hämäläinen, M, Tolonen, T, Mäki, M, Jaakkola, M, Peltola, R et al.. Lingonberry (- L.) Skin Extract Prevents Weight Gain and Hyperglycemia in High-Fat Diet-Induced Model of Obesity in Mice. Nutrients. 2024;16 (13):. doi: 10.3390/nu16132107. PubMed PMID:38999854 PubMed Central PMC11243352.
  33. Jonsdottir, B, Clasen, JL, Vehik, K, Lernmark, Å, Lundgren, M, Bonifacio, E et al.. Early appearance of thyroid autoimmunity in children followed from birth for type 1 diabetes risk. J Clin Endocrinol Metab. 2024; :. doi: 10.1210/clinem/dgae478. PubMed PMID:38996042 .
  34. Madhi, SA, Ceballos, A, Cousin, L, Domachowske, JB, Langley, JM, Lu, E et al.. Population Attributable Risk of Wheeze in 2-<6-Year-old Children, Following a Respiratory Syncytial Virus Lower Respiratory Tract Infection in The First 2 Years of Life. Pediatr Infect Dis J. 2024; :. doi: 10.1097/INF.0000000000004447. PubMed PMID:38985986 .
  35. Soppela, S, Plavec, Z, Gröhn, S, Jartti, M, Oikarinen, S, Laajala, M et al.. Comparison of structure and immunogenicity of CVB1-VLP and inactivated CVB1 vaccine candidates. Res Sq. 2024; :. doi: 10.21203/rs.3.rs-4545395/v1. PubMed PMID:38978565 PubMed Central PMC11230480.
  36. Lampinen, V, Gröhn, S, Lehmler, N, Jartti, M, Hytönen, VP, Schubert, M et al.. Production of norovirus-, rotavirus-, and enterovirus-like particles in insect cells is simplified by plasmid-based expression. Sci Rep. 2024;14 (1):14874. doi: 10.1038/s41598-024-65316-6. PubMed PMID:38937523 PubMed Central PMC11211442.
  37. Niinistö, S, Cuthbertson, D, Miettinen, ME, Hakola, L, Nucci, A, Korhonen, TE et al.. High Concentrations of Immunoglobulin G Against Cow Milk Proteins and Frequency of Cow Milk Consumption Are Associated With the Development of Islet Autoimmunity and Type 1 Diabetes-The Trial to Reduce Insulin-dependent Diabetes Mellitus (IDDM) in the Genetically at Risk (TRIGR) Study. J Nutr. 2024;154 (8):2493-2500. doi: 10.1016/j.tjnut.2024.06.005. PubMed PMID:38906178 PubMed Central PMC11375457.
  38. Sidibé, A, Mykuliak, VV, Zhang, P, Hytönen, VP, Wu, J, Wehrle-Haller, B et al.. Acetyl-NPKY of integrin-β1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity. iScience. 2024;27 (6):110129. doi: 10.1016/j.isci.2024.110129. PubMed PMID:38904068 PubMed Central PMC11187247.
  39. Hakola, L, Lund-Blix, NA, Takkinen, HM, Tapanainen, H, Niinistö, S, Korhonen, TE et al.. Maternal gluten, cereal, and dietary fiber intake during pregnancy and lactation and the risk of islet autoimmunity and type 1 diabetes in the child. Clin Nutr ESPEN. 2024;62 :22-27. doi: 10.1016/j.clnesp.2024.05.001. PubMed PMID:38901945 .
  40. Goswami, J, Baqui, AH, Doreski, PA, Perez Marc, G, Jimenez, G, Ahmed, S et al.. Humoral Immunogenicity of mRNA-1345 RSV Vaccine in Older Adults. J Infect Dis. 2024;230 (5):e996-e1006. doi: 10.1093/infdis/jiae316. PubMed PMID:38889247 PubMed Central PMC11566230.
  41. Miao, Y, Virtanen, A, Zmajkovic, J, Hilpert, M, Skoda, RC, Silvennoinen, O et al.. Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity. J Med Chem. 2024;67 (12):10012-10024. doi: 10.1021/acs.jmedchem.4c00197. PubMed PMID:38843875 PubMed Central PMC11215726.
  42. Evans, AD, Pournoori, N, Saksala, E, Oommen, OP. Glycosaminoglycans’ for brain health: Harnessing glycosaminoglycan based biomaterials for treating central nervous system diseases and in-vitro modeling. Biomaterials. 2024;309 :122629. doi: 10.1016/j.biomaterials.2024.122629. PubMed PMID:38797120 .
  43. Salo, TE, Hakola, L, Niinistö, S, Takkinen, HM, Ahonen, S, Puustinen, L et al.. Gut Inflammation Markers, Diet, and Risk of Islet Autoimmunity in Finnish Children – A Nested Case-Control Study. J Nutr. 2024;154 (7):2244-2254. doi: 10.1016/j.tjnut.2024.05.015. PubMed PMID:38795745 PubMed Central PMC11282497.
  44. Tissarinen, P, Tiensuu, H, Haapalainen, AM, Ronkainen, E, Laatio, L, Vääräsmäki, M et al.. Maternal serum alpha-1 antitrypsin levels in spontaneous preterm and term pregnancies. Sci Rep. 2024;14 (1):10819. doi: 10.1038/s41598-024-61206-z. PubMed PMID:38734716 PubMed Central PMC11088650.
  45. Starskaia, I, Valta, M, Pietilä, S, Suomi, T, Pahkuri, S, Kalim, UU et al.. Distinct cellular immune responses in children en route to type 1 diabetes with different first-appearing autoantibodies. Nat Commun. 2024;15 (1):3810. doi: 10.1038/s41467-024-47918-w. PubMed PMID:38714671 PubMed Central PMC11076468.
  46. Saarenpää, M, Roslund, MI, Nurminen, N, Puhakka, R, Kummola, L, Laitinen, OH et al.. Urban indoor gardening enhances immune regulation and diversifies skin microbiota – A placebo-controlled double-blinded intervention study. Environ Int. 2024;187 :108705. doi: 10.1016/j.envint.2024.108705. PubMed PMID:38688234 .
  47. Leclerc, S, Gupta, A, Ruokolainen, V, Chen, JH, Kunnas, K, Ekman, AA et al.. Progression of herpesvirus infection remodels mitochondrial organization and metabolism. PLoS Pathog. 2024;20 (4):e1011829. doi: 10.1371/journal.ppat.1011829. PubMed PMID:38620036 PubMed Central PMC11045090.
  48. Atomwise AIMS Program. AI is a viable alternative to high throughput screening: a 318-target study. Sci Rep. 2024;14 (1):7526. doi: 10.1038/s41598-024-54655-z. PubMed PMID:38565852 PubMed Central PMC10987645.
  49. Meinhardt, A, Reilly, L, Kaliakatsos, M, Abdel-Aziz, K, Alsharidah, S, Bodi, I et al.. Novel antivirals for severe enterovirus infection in immunocompromised hosts; A case series. J Infect. 2024;88 (5):106142. doi: 10.1016/j.jinf.2024.106142. PubMed PMID:38527653 .
  50. Mäenpää, N, Tiainen, L, Hämäläinen, M, Luukkaala, T, Tanner, M, Lahdenperä, O et al.. Neuropilin-1 and placental growth factor as prognostic factors in metastatic breast cancer. BMC Cancer. 2024;24 (1):331. doi: 10.1186/s12885-024-12070-7. PubMed PMID:38468231 PubMed Central PMC10929217.
  51. Abraham, BG, Haikarainen, T, Vuorio, J, Girych, M, Virtanen, AT, Kurttila, A et al.. Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling. Sci Adv. 2024;10 (10):eadl2097. doi: 10.1126/sciadv.adl2097. PubMed PMID:38457493 PubMed Central PMC10923518.
  52. Vecchio, F, Carré, A, Korenkov, D, Zhou, Z, Apaolaza, P, Tuomela, S et al.. Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8 T cell responses. Sci Adv. 2024;10 (10):eadl1122. doi: 10.1126/sciadv.adl1122. PubMed PMID:38446892 PubMed Central PMC10917340.
  53. Lehtola, T, Nummenmaa, E, Nieminen, R, Hämäläinen, M, Vuolteenaho, K, Moilanen, E et al.. The glucocorticoid dexamethasone alleviates allergic inflammation through a mitogen-activated protein kinase phosphatase-1-dependent mechanism in mice. Basic Clin Pharmacol Toxicol. 2024;134 (5):686-694. doi: 10.1111/bcpt.13995. PubMed PMID:38439200 .
  54. Savijoki, K, Deptula, P, Roberts, RJ, Hammarén, M, Yli-Kauhaluoma, J, Varmanen, P et al.. Revised whole genome and DNA methylome of type strain ATCC 927. Microbiol Resour Announc. 2024;13 (4):e0101623. doi: 10.1128/mra.01016-23. PubMed PMID:38415640 PubMed Central PMC11008211.
  55. Hakola, L, Mramba, LK, Uusitalo, U, Andrén Aronsson, C, Hummel, S, Niinistö, S et al.. Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study. Eur J Nutr. 2024;63 (4):1329-1338. doi: 10.1007/s00394-024-03346-6. PubMed PMID:38413484 PubMed Central PMC11139689.
  56. Kokko, E, Choudhary, MK, Mutanen, A, Honkonen, M, Tikkakoski, A, Koskela, JK et al.. Volume overload is a major characteristic in primary aldosteronism: a 3-year follow-up study. J Hypertens. 2024;42 (6):1057-1065. doi: 10.1097/HJH.0000000000003696. PubMed PMID:38406920 PubMed Central PMC11064919.
  57. Hyöty, H, Kääriäinen, S, Laiho, JE, Comer, GM, Tian, W, Härkönen, T et al.. Safety, tolerability and immunogenicity of PRV-101, a multivalent vaccine targeting coxsackie B viruses (CVBs) associated with type 1 diabetes: a double-blind randomised placebo-controlled Phase I trial. Diabetologia. 2024;67 (5):811-821. doi: 10.1007/s00125-024-06092-w. PubMed PMID:38369573 PubMed Central PMC10954874.
  58. Curran, D, Matthews, S, Cabrera, ES, Pérez, SN, Breva, LP, Rämet, M et al.. The respiratory syncytial virus prefusion F protein vaccine attenuates the severity of respiratory syncytial virus-associated disease in breakthrough infections in adults ≥60 years of age. Influenza Other Respir Viruses. 2024;18 (2):e13236. doi: 10.1111/irv.13236. PubMed PMID:38314063 PubMed Central PMC10837780.
  59. Sáez-Llorens, X, Norero, X, Mussi-Pinhata, MM, Luciani, K, de la Cueva, IS, Díez-Domingo, J et al.. Safety and Immunogenicity of a ChAd155-Vectored Respiratory Syncytial Virus Vaccine in Infants 6-7 Months of age: A Phase 1/2 Randomized Trial. J Infect Dis. 2024;229 (1):95-107. doi: 10.1093/infdis/jiad271. PubMed PMID:37477875 PubMed Central PMC10786261.

Search PubMed

2023

  1. Nigi, L, Laiho, JE, Hyöty, H, Dotta, F. Editorial: The contribution of viruses and innate immune system in the pathogenesis of type 1 diabetes. Front Endocrinol (Lausanne). 2023;14 :1335716. doi: 10.3389/fendo.2023.1335716. PubMed PMID:38161972 PubMed Central PMC10757338.
  2. Zapilko, V, Moisio, S, Parikka, M, Heinäniemi, M, Lohi, O. Generation of a Zebrafish Knock-In Model Recapitulating Childhood ETV6::RUNX1-Positive B-Cell Precursor Acute Lymphoblastic Leukemia. Cancers (Basel). 2023;15 (24):. doi: 10.3390/cancers15245821. PubMed PMID:38136366 PubMed Central PMC10871125.
  3. Rahikainen, R, Vester, SK, Turkki, P, Janosko, CP, Deiters, A, Hytönen, VP et al.. Visible Light-Induced Specific Protein Reaction Delineates Early Stages of Cell Adhesion. J Am Chem Soc. 2023;145 (45):24459-24465. doi: 10.1021/jacs.3c07827. PubMed PMID:38104267 PubMed Central PMC10655181.
  4. Wilson, E, Goswami, J, Baqui, AH, Doreski, PA, Perez-Marc, G, Zaman, K et al.. Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults. N Engl J Med. 2023;389 (24):2233-2244. doi: 10.1056/NEJMoa2307079. PubMed PMID:38091530 .
  5. Nygård, L, Valta, M, Laine, AP, Toppari, J, Knip, M, Veijola, R et al.. CXADR polymorphism rs6517774 modifies islet autoimmunity characteristics and exhibits sex disparity. Front Genet. 2023;14 :1248701. doi: 10.3389/fgene.2023.1248701. PubMed PMID:38028613 PubMed Central PMC10651746.
  6. Lin, J, Moradi, E, Salenius, K, Lehtipuro, S, Häkkinen, T, Laiho, JE et al.. Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection. Nat Commun. 2023;14 (1):7630. doi: 10.1038/s41467-023-42763-9. PubMed PMID:37993433 PubMed Central PMC10665402.
  7. Patrakka, O, Tuomisto, S, Pienimäki, JP, Ollikainen, J, Oksala, N, Lampinen, V et al.. Thrombus Aspirates From Patients With Acute Ischemic Stroke Are Infiltrated by Viridans Streptococci. J Am Heart Assoc. 2023;12 (22):e030639. doi: 10.1161/JAHA.123.030639. PubMed PMID:37982253 PubMed Central PMC10727284.
  8. Mäki-Koivisto, V, Korkala, M, Simola, L, Suutari-Kontio, S, Koivunen, S, Puhto, T et al.. Positive Francisella tularensis meningitis outcome despite delayed identification: a case report. Ann Clin Microbiol Antimicrob. 2023;22 (1):92. doi: 10.1186/s12941-023-00642-7. PubMed PMID:37875923 PubMed Central PMC10598999.
  9. Pasanen, A, Karjalainen, MK, FinnGen, Zhang, G, Tiensuu, H, Haapalainen, AM et al.. Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci. PLoS Genet. 2023;19 (10):e1010982. doi: 10.1371/journal.pgen.1010982. PubMed PMID:37871108 PubMed Central PMC10621942.
  10. Krogvold, L, Mynarek, IM, Ponzi, E, Mørk, FB, Hessel, TW, Roald, T et al.. Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 randomized trial. Nat Med. 2023;29 (11):2902-2908. doi: 10.1038/s41591-023-02576-1. PubMed PMID:37789144 PubMed Central PMC10667091.
  11. Lamichhane, S, Sen, P, Dickens, AM, Kråkström, M, Ilonen, J, Lempainen, J et al.. Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children. Front Endocrinol (Lausanne). 2023;14 :1211015. doi: 10.3389/fendo.2023.1211015. PubMed PMID:37745723 PubMed Central PMC10516565.
  12. Hirvonen, MK, Lietzén, N, Moulder, R, Bhosale, SD, Koskenniemi, J, Vähä-Mäkilä, M et al.. Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes. Sci Rep. 2023;13 (1):15941. doi: 10.1038/s41598-023-43039-4. PubMed PMID:37743383 PubMed Central PMC10518308.
  13. Wicaksono, WA, Cernava, T, Wassermann, B, Abdelfattah, A, Soto-Giron, MJ, Toledo, GV et al.. The edible plant microbiome: evidence for the occurrence of fruit and vegetable bacteria in the human gut. Gut Microbes. 2023;15 (2):2258565. doi: 10.1080/19490976.2023.2258565. PubMed PMID:37741805 PubMed Central PMC10519362.
  14. Kummola, L, González-Rodríguez, MI, Marnila, P, Nurminen, N, Salomaa, T, Hiihtola, L et al.. Comparison of the effect of autoclaved and non-autoclaved live soil exposure on the mouse immune system : Effect of soil exposure on immune system. BMC Immunol. 2023;24 (1):29. doi: 10.1186/s12865-023-00565-0. PubMed PMID:37689649 PubMed Central PMC10492337.
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2022

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