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VACCIM

Research Center for Vaccine Development and Immunology

Publications

2024

  1. Leclerc, S, Gupta, A, Ruokolainen, V, Chen, JH, Kunnas, K, Ekman, AA et al.. Progression of herpesvirus infection remodels mitochondrial organization and metabolism. PLoS Pathog. 2024;20 (4):e1011829. doi: 10.1371/journal.ppat.1011829. PubMed PMID:38620036 .
  2. Atomwise AIMS Program. AI is a viable alternative to high throughput screening: a 318-target study. Sci Rep. 2024;14 (1):7526. doi: 10.1038/s41598-024-54655-z. PubMed PMID:38565852 PubMed Central PMC10987645.
  3. Meinhardt, A, Reilly, L, Kaliakatsos, M, Abdel-Aziz, K, Alsharidah, S, Bodi, I et al.. Novel antivirals for severe enterovirus infection in immunocompromised hosts; A case series. J Infect. 2024;88 (5):106142. doi: 10.1016/j.jinf.2024.106142. PubMed PMID:38527653 .
  4. Mäenpää, N, Tiainen, L, Hämäläinen, M, Luukkaala, T, Tanner, M, Lahdenperä, O et al.. Neuropilin-1 and placental growth factor as prognostic factors in metastatic breast cancer. BMC Cancer. 2024;24 (1):331. doi: 10.1186/s12885-024-12070-7. PubMed PMID:38468231 PubMed Central PMC10929217.
  5. Abraham, BG, Haikarainen, T, Vuorio, J, Girych, M, Virtanen, AT, Kurttila, A et al.. Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling. Sci Adv. 2024;10 (10):eadl2097. doi: 10.1126/sciadv.adl2097. PubMed PMID:38457493 PubMed Central PMC10923518.
  6. Vecchio, F, Carré, A, Korenkov, D, Zhou, Z, Apaolaza, P, Tuomela, S et al.. Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8 T cell responses. Sci Adv. 2024;10 (10):eadl1122. doi: 10.1126/sciadv.adl1122. PubMed PMID:38446892 PubMed Central PMC10917340.
  7. Lehtola, T, Nummenmaa, E, Nieminen, R, Hämäläinen, M, Vuolteenaho, K, Moilanen, E et al.. The glucocorticoid dexamethasone alleviates allergic inflammation through a mitogen-activated protein kinase phosphatase-1-dependent mechanism in mice. Basic Clin Pharmacol Toxicol. 2024;134 (5):686-694. doi: 10.1111/bcpt.13995. PubMed PMID:38439200 .
  8. Savijoki, K, Deptula, P, Roberts, RJ, Hammarén, M, Yli-Kauhaluoma, J, Varmanen, P et al.. Revised whole genome and DNA methylome of type strain ATCC 927. Microbiol Resour Announc. 2024;13 (4):e0101623. doi: 10.1128/mra.01016-23. PubMed PMID:38415640 PubMed Central PMC11008211.
  9. Hakola, L, Mramba, LK, Uusitalo, U, Andrén Aronsson, C, Hummel, S, Niinistö, S et al.. Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study. Eur J Nutr. 2024; :. doi: 10.1007/s00394-024-03346-6. PubMed PMID:38413484 .
  10. Kokko, E, Choudhary, MK, Mutanen, A, Honkonen, M, Tikkakoski, A, Koskela, JK et al.. Volume overload is a major characteristic in primary aldosteronism: a 3-year follow-up study. J Hypertens. 2024; :. doi: 10.1097/HJH.0000000000003696. PubMed PMID:38406920 .
  11. Hyöty, H, Kääriäinen, S, Laiho, JE, Comer, GM, Tian, W, Härkönen, T et al.. Safety, tolerability and immunogenicity of PRV-101, a multivalent vaccine targeting coxsackie B viruses (CVBs) associated with type 1 diabetes: a double-blind randomised placebo-controlled Phase I trial. Diabetologia. 2024;67 (5):811-821. doi: 10.1007/s00125-024-06092-w. PubMed PMID:38369573 PubMed Central PMC10954874.
  12. Curran, D, Matthews, S, Cabrera, ES, Pérez, SN, Breva, LP, Rämet, M et al.. The respiratory syncytial virus prefusion F protein vaccine attenuates the severity of respiratory syncytial virus-associated disease in breakthrough infections in adults ≥60 years of age. Influenza Other Respir Viruses. 2024;18 (2):e13236. doi: 10.1111/irv.13236. PubMed PMID:38314063 PubMed Central PMC10837780.
  13. Sáez-Llorens, X, Norero, X, Mussi-Pinhata, MM, Luciani, K, de la Cueva, IS, Díez-Domingo, J et al.. Safety and Immunogenicity of a ChAd155-Vectored Respiratory Syncytial Virus Vaccine in Infants 6-7 Months of age: A Phase 1/2 Randomized Trial. J Infect Dis. 2024;229 (1):95-107. doi: 10.1093/infdis/jiad271. PubMed PMID:37477875 PubMed Central PMC10786261.

Search PubMed

2023

  1. Nigi, L, Laiho, JE, Hyöty, H, Dotta, F. Editorial: The contribution of viruses and innate immune system in the pathogenesis of type 1 diabetes. Front Endocrinol (Lausanne). 2023;14 :1335716. doi: 10.3389/fendo.2023.1335716. PubMed PMID:38161972 PubMed Central PMC10757338.
  2. Zapilko, V, Moisio, S, Parikka, M, Heinäniemi, M, Lohi, O. Generation of a Zebrafish Knock-In Model Recapitulating Childhood ETV6::RUNX1-Positive B-Cell Precursor Acute Lymphoblastic Leukemia. Cancers (Basel). 2023;15 (24):. doi: 10.3390/cancers15245821. PubMed PMID:38136366 PubMed Central PMC10871125.
  3. Rahikainen, R, Vester, SK, Turkki, P, Janosko, CP, Deiters, A, Hytönen, VP et al.. Visible Light-Induced Specific Protein Reaction Delineates Early Stages of Cell Adhesion. J Am Chem Soc. 2023;145 (45):24459-24465. doi: 10.1021/jacs.3c07827. PubMed PMID:38104267 PubMed Central PMC10655181.
  4. Wilson, E, Goswami, J, Baqui, AH, Doreski, PA, Perez-Marc, G, Zaman, K et al.. Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults. N Engl J Med. 2023;389 (24):2233-2244. doi: 10.1056/NEJMoa2307079. PubMed PMID:38091530 .
  5. Nygård, L, Valta, M, Laine, AP, Toppari, J, Knip, M, Veijola, R et al.. CXADR polymorphism rs6517774 modifies islet autoimmunity characteristics and exhibits sex disparity. Front Genet. 2023;14 :1248701. doi: 10.3389/fgene.2023.1248701. PubMed PMID:38028613 PubMed Central PMC10651746.
  6. Lin, J, Moradi, E, Salenius, K, Lehtipuro, S, Häkkinen, T, Laiho, JE et al.. Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection. Nat Commun. 2023;14 (1):7630. doi: 10.1038/s41467-023-42763-9. PubMed PMID:37993433 PubMed Central PMC10665402.
  7. Patrakka, O, Tuomisto, S, Pienimäki, JP, Ollikainen, J, Oksala, N, Lampinen, V et al.. Thrombus Aspirates From Patients With Acute Ischemic Stroke Are Infiltrated by Viridans Streptococci. J Am Heart Assoc. 2023;12 (22):e030639. doi: 10.1161/JAHA.123.030639. PubMed PMID:37982253 PubMed Central PMC10727284.
  8. Mäki-Koivisto, V, Korkala, M, Simola, L, Suutari-Kontio, S, Koivunen, S, Puhto, T et al.. Positive Francisella tularensis meningitis outcome despite delayed identification: a case report. Ann Clin Microbiol Antimicrob. 2023;22 (1):92. doi: 10.1186/s12941-023-00642-7. PubMed PMID:37875923 PubMed Central PMC10598999.
  9. Pasanen, A, Karjalainen, MK, FinnGen, Zhang, G, Tiensuu, H, Haapalainen, AM et al.. Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci. PLoS Genet. 2023;19 (10):e1010982. doi: 10.1371/journal.pgen.1010982. PubMed PMID:37871108 PubMed Central PMC10621942.
  10. Krogvold, L, Mynarek, IM, Ponzi, E, Mørk, FB, Hessel, TW, Roald, T et al.. Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 randomized trial. Nat Med. 2023;29 (11):2902-2908. doi: 10.1038/s41591-023-02576-1. PubMed PMID:37789144 PubMed Central PMC10667091.
  11. Lamichhane, S, Sen, P, Dickens, AM, Kråkström, M, Ilonen, J, Lempainen, J et al.. Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children. Front Endocrinol (Lausanne). 2023;14 :1211015. doi: 10.3389/fendo.2023.1211015. PubMed PMID:37745723 PubMed Central PMC10516565.
  12. Hirvonen, MK, Lietzén, N, Moulder, R, Bhosale, SD, Koskenniemi, J, Vähä-Mäkilä, M et al.. Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes. Sci Rep. 2023;13 (1):15941. doi: 10.1038/s41598-023-43039-4. PubMed PMID:37743383 PubMed Central PMC10518308.
  13. Wicaksono, WA, Cernava, T, Wassermann, B, Abdelfattah, A, Soto-Giron, MJ, Toledo, GV et al.. The edible plant microbiome: evidence for the occurrence of fruit and vegetable bacteria in the human gut. Gut Microbes. 2023;15 (2):2258565. doi: 10.1080/19490976.2023.2258565. PubMed PMID:37741805 PubMed Central PMC10519362.
  14. Kummola, L, González-Rodríguez, MI, Marnila, P, Nurminen, N, Salomaa, T, Hiihtola, L et al.. Comparison of the effect of autoclaved and non-autoclaved live soil exposure on the mouse immune system : Effect of soil exposure on immune system. BMC Immunol. 2023;24 (1):29. doi: 10.1186/s12865-023-00565-0. PubMed PMID:37689649 PubMed Central PMC10492337.
  15. Vecchio, F, Carré, A, Korenkov, D, Zhou, Z, Apaolaza, P, Tuomela, S et al.. Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses. bioRxiv. 2023; :. doi: 10.1101/2023.08.19.553954. PubMed PMID:37662376 PubMed Central PMC10473604.
  16. Dotsenko, V, Sioofy-Khojine, AB, Hyöty, H, Viiri, K. Human intestinal organoid models for celiac disease research. Methods Cell Biol. 2023;179 :173-193. doi: 10.1016/bs.mcb.2023.01.008. PubMed PMID:37625874 .
  17. Lönnrot, M, Lynch, KF, Rewers, M, Lernmark, Å, Vehik, K, Akolkar, B et al.. Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study. Diabetes Care. 2023;46 (11):1908-1915. doi: 10.2337/dc23-0518. PubMed PMID:37607456 PubMed Central PMC10620548.
  18. Tavakoli, S, Evans, A, Oommen, OP, Creemers, L, Nandi, JB, Hilborn, J et al.. Unveiling extracellular matrix assembly: Insights and approaches through bioorthogonal chemistry. Mater Today Bio. 2023;22 :100768. doi: 10.1016/j.mtbio.2023.100768. PubMed PMID:37600348 PubMed Central PMC10432810.
  19. Uusitalo, U, Mramba, LK, Aronsson, CA, Vehik, K, Yang, J, Hummel, S et al.. HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study. Diabetes Care. 2023;46 (10):1839-1847. doi: 10.2337/dc23-0417. PubMed PMID:37579501 PubMed Central PMC10516243.
  20. Krischer, JP, Lernmark, Å, Hagopian, WA, Rewers, MJ, McIndoe, R, Toppari, J et al.. SARS-CoV-2 – No Increased Islet Autoimmunity or Type 1 Diabetes in Teens. N Engl J Med. 2023;389 (5):474-475. doi: 10.1056/NEJMc2216477. PubMed PMID:37530831 PubMed Central PMC10481371.
  21. Rahikainen, R, Vester, SK, Turkki, P, Janosko, CP, Deiters, A, Hytönen, VP et al.. Visible light-induced specific protein reaction delineates early stages of cell adhesion. bioRxiv. 2023; :. doi: 10.1101/2023.07.21.549850. PubMed PMID:37503248 PubMed Central PMC10370186.
  22. Seitz, I, Saarinen, S, Kumpula, EP, McNeale, D, Anaya-Plaza, E, Lampinen, V et al.. DNA-origami-directed virus capsid polymorphism. Nat Nanotechnol. 2023;18 (10):1205-1212. doi: 10.1038/s41565-023-01443-x. PubMed PMID:37460794 PubMed Central PMC10575778.
  23. Laajala, M, Zwaagstra, M, Martikainen, M, Nekoua, MP, Benkahla, M, Sane, F et al.. Vemurafenib Inhibits Acute and Chronic Enterovirus Infection by Affecting Cellular Kinase Phosphatidylinositol 4-Kinase Type IIIβ. Microbiol Spectr. 2023;11 (4):e0055223. doi: 10.1128/spectrum.00552-23. PubMed PMID:37436162 PubMed Central PMC10433971.
  24. Lampinen, V, Gröhn, S, Soppela, S, Blazevic, V, Hytönen, VP, Hankaniemi, MM et al.. SpyTag/SpyCatcher display of influenza M2e peptide on norovirus-like particle provides stronger immunization than direct genetic fusion. Front Cell Infect Microbiol. 2023;13 :1216364. doi: 10.3389/fcimb.2023.1216364. PubMed PMID:37424789 PubMed Central PMC10323135.
  25. Luostarinen, S, Hämäläinen, M, Pemmari, A, Moilanen, E. The regulation of TRPA1 expression and function by Th1 and Th2-type inflammation in human A549 lung epithelial cells. Inflamm Res. 2023;72 (7):1327-1339. doi: 10.1007/s00011-023-01750-y. PubMed PMID:37386145 PubMed Central PMC10352175.
  26. Halonen, L, Pemmari, A, Nummenmaa, E, Hämäläinen, M, Moilanen, T, Vuolteenaho, K et al.. Human Osteoarthritic Chondrocytes Express Nineteen Different TRP-Genes-TRPA1 and TRPM8 as Potential Drug Targets. Int J Mol Sci. 2023;24 (12):. doi: 10.3390/ijms241210057. PubMed PMID:37373205 PubMed Central PMC10298562.
  27. Arwood, ML, Liu, Y, Harkins, SK, Weinstock, DM, Yang, L, Stevenson, KE et al.. New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation. Cell Chem Biol. 2023;30 (6):618-631.e12. doi: 10.1016/j.chembiol.2023.05.007. PubMed PMID:37290440 PubMed Central PMC10495080.
  28. Salomaa, T, Kummola, L, González-Rodríguez, MI, Hiihtola, L, Järvinen, TAH, Junttila, IS et al.. Low IL-13Rα1 expression on mast cells tunes them unresponsive to IL-13. J Leukoc Biol. 2023;114 (2):187-194. doi: 10.1093/jleuko/qiad065. PubMed PMID:37224625 .
  29. Hammarén, MM, Luukinen, H, Sillanpää, A, Remans, K, Lapouge, K, Custódio, T et al.. and proteomics of biofilms and the development of biofilm-binding synthetic nanobodies. mSystems. 2023;8 (3):e0107322. doi: 10.1128/msystems.01073-22. PubMed PMID:37184670 PubMed Central PMC10308901.
  30. Saarikettu, J, Lehmusvaara, S, Pesu, M, Junttila, I, Partanen, J, Sipilä, P et al.. The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression. FASEB Bioadv. 2023;5 (5):183-198. doi: 10.1096/fba.2022-00115. PubMed PMID:37151849 PubMed Central PMC10158624.
  31. Pölläniemi, A, Virtanen, A, Silvennoinen, O, Haikarainen, T. Development of an enzyme-coupled activity assay for Janus kinase 2 inhibitor screening. SLAS Discov. 2023;28 (4):180-187. doi: 10.1016/j.slasd.2023.05.001. PubMed PMID:37149038 .
  32. Liu, X, Johnson, SB, Lynch, KF, Cordan, K, Pate, R, Butterworth, MD et al.. Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5- to 15-Year-Old Children Followed in the TEDDY Study. Diabetes Care. 2023;46 (7):1409-1416. doi: 10.2337/dc23-0036. PubMed PMID:37141102 PubMed Central PMC10300517.
  33. Virtanen, A, Palmroth, M, Liukkonen, S, Kurttila, A, Haikarainen, T, Isomäki, P et al.. Differences in JAK Isoform Selectivity Among Different Types of JAK Inhibitors Evaluated for Rheumatic Diseases Through In Vitro Profiling. Arthritis Rheumatol. 2023;75 (11):2054-2061. doi: 10.1002/art.42547. PubMed PMID:37134144 .
  34. Bachmann, M, Su, B, Rahikainen, R, Hytönen, VP, Wu, J, Wehrle-Haller, B et al.. ConFERMing the role of talin in integrin activation and mechanosignaling. J Cell Sci. 2023;136 (8):. doi: 10.1242/jcs.260576. PubMed PMID:37078342 PubMed Central PMC10198623.
  35. Voor, T, Pärtel, M, Peet, A, Saare, L, Hyöty, H, Knip, M et al.. Atopic sensitization in childhood depends on the type of green area around the home in infancy. Clin Exp Allergy. 2023;53 (8):850-853. doi: 10.1111/cea.14317. PubMed PMID:37038920 .
  36. Muller, WJ, Madhi, SA, Seoane Nuñez, B, Baca Cots, M, Bosheva, M, Dagan, R et al.. Nirsevimab for Prevention of RSV in Term and Late-Preterm Infants. N Engl J Med. 2023;388 (16):1533-1534. doi: 10.1056/NEJMc2214773. PubMed PMID:37018470 .
  37. Walsh, EE, Pérez Marc, G, Zareba, AM, Falsey, AR, Jiang, Q, Patton, M et al.. Efficacy and Safety of a Bivalent RSV Prefusion F Vaccine in Older Adults. N Engl J Med. 2023;388 (16):1465-1477. doi: 10.1056/NEJMoa2213836. PubMed PMID:37018468 .
  38. Ojanen, MJT, Caro, FM, Aittomäki, S, Ploquin, MJ, Ortutay, Z, Pekkarinen, M et al.. FURIN regulates cytotoxic T-lymphocyte effector function and memory cell transition in mice. Eur J Immunol. 2023;53 (6):e2250246. doi: 10.1002/eji.202250246. PubMed PMID:37015057 .
  39. Taurio, J, Hautaniemi, EJ, Koskela, JK, Eräranta, A, Hämäläinen, M, Tikkakoski, A et al.. The characteristics of elevated blood pressure in abdominal obesity correspond to primary hypertension: a cross-sectional study. BMC Cardiovasc Disord. 2023;23 (1):161. doi: 10.1186/s12872-023-03150-w. PubMed PMID:36973671 PubMed Central PMC10045516.
  40. Sioofy-Khojine, AB, Lehtonen, JP, Nurminen, N, Laiho, JE, Toppari, J, Veijola, R et al.. HLA-DQ-conferred risk for type 1 diabetes does not alter neutralizing antibody response to a widely used enterovirus vaccine, the poliovirus vaccine. J Med Virol. 2023;95 (4):e28707. doi: 10.1002/jmv.28707. PubMed PMID:36971180 .
  41. Mahmoud, M, Juntunen, M, Adnan, A, Kummola, L, Junttila, IS, Kelloniemi, M et al.. Immunomodulatory Functions of Adipose Mesenchymal Stromal/Stem Cell Derived From Donors With Type 2 Diabetes and Obesity on CD4 T Cells. Stem Cells. 2023;41 (5):505-519. doi: 10.1093/stmcls/sxad021. PubMed PMID:36945068 PubMed Central PMC10183970.
  42. Roslund, MI, Parajuli, A, Hui, N, Puhakka, R, Grönroos, M, Soininen, L et al.. Skin, gut, and sand metagenomic data on placebo-controlled sandbox biodiversity intervention study. Data Brief. 2023;47 :109003. doi: 10.1016/j.dib.2023.109003. PubMed PMID:36915639 PubMed Central PMC10006422.
  43. Scotece, M, Hämäläinen, M, Leppänen, T, Vuolteenaho, K, Moilanen, E. MKP-1 Deficiency Exacerbates Skin Fibrosis in a Mouse Model of Scleroderma. Int J Mol Sci. 2023;24 (5):. doi: 10.3390/ijms24054668. PubMed PMID:36902103 PubMed Central PMC10002998.
  44. Thorsen, SU, Liu, X, Kataria, Y, Mandrup-Poulsen, T, Kaur, S, Uusitalo, U et al.. Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2023;46 (5):1014-1018. doi: 10.2337/dc22-1359. PubMed PMID:36867433 PubMed Central PMC10154662.
  45. Pavic, K, Gupta, N, Omella, JD, Derua, R, Aakula, A, Huhtaniemi, R et al.. Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A. Nat Commun. 2023;14 (1):1143. doi: 10.1038/s41467-023-36693-9. PubMed PMID:36854761 PubMed Central PMC9974998.
  46. Benfield, T, Rämet, M, Valentini, P, Seppä, I, Dagan, R, Richmond, P et al.. Safety, tolerability, and immunogenicity of V114 pneumococcal vaccine compared with PCV13 in a 2+1 regimen in healthy infants: A phase III study (PNEU-PED-EU-2). Vaccine. 2023;41 (15):2456-2465. doi: 10.1016/j.vaccine.2023.02.041. PubMed PMID:36841723 .
  47. Kummola, L, Salomaa, T, Ortutay, Z, Savan, R, Young, HA, Junttila, IS et al.. IL-4, IL-13 and IFN-γ -induced genes in highly purified human neutrophils. Cytokine. 2023;164 :156159. doi: 10.1016/j.cyto.2023.156159. PubMed PMID:36809715 PubMed Central PMC10331420.
  48. Wu, R, Mumtaz, M, Maxwell, AJ, Isaacs, SR, Laiho, JE, Rawlinson, WD et al.. Respiratory infections and type 1 diabetes: Potential roles in pathogenesis. Rev Med Virol. 2023;33 (2):e2429. doi: 10.1002/rmv.2429. PubMed PMID:36790804 PubMed Central PMC10909571.
  49. Tissarinen, P, Tiensuu, H, Haapalainen, AM, Määttä, TA, Ojaniemi, M, Hallman, M et al.. Elevated human placental heat shock protein 5 is associated with spontaneous preterm birth. Pediatr Res. 2023;94 (2):520-529. doi: 10.1038/s41390-023-02501-9. PubMed PMID:36788289 PubMed Central PMC9926443.
  50. Rangasami, VK, Asawa, K, Teramura, Y, Le Blanc, K, Nilsson, B, Hilborn, J et al.. Biomimetic polyelectrolyte coating of stem cells suppresses thrombotic activation and enhances its survival and function. Biomater Adv. 2023;147 :213331. doi: 10.1016/j.bioadv.2023.213331. PubMed PMID:36773382 .
  51. Koskela, K, Sauni, R, Uitti, J, Oksa, P, Moilanen, E, Hämäläinen, M et al.. An Increase in Plasma Adipsin Levels Is Associated With Higher Cumulative Dust Exposure and Airway Obstruction in Foundry Workers. J Occup Environ Med. 2023;65 (3):203-209. doi: 10.1097/JOM.0000000000002736. PubMed PMID:36730948 .
  52. Taurio, J, Koskela, J, Sinisalo, M, Tikkakoski, A, Niemelä, O, Hämäläinen, M et al.. Urine sodium excretion is related to extracellular water volume but not to blood pressure in 510 normotensive and never-treated hypertensive subjects. Blood Press. 2023;32 (1):2170869. doi: 10.1080/08037051.2023.2170869. PubMed PMID:36708156 .
  53. Mäki-Opas, I, Hämäläinen, M, Moilanen, E, Scotece, M. TRPA1 as a potential factor and drug target in scleroderma: dermal fibrosis and alternative macrophage activation are attenuated in TRPA1-deficient mice in bleomycin-induced experimental model of scleroderma. Arthritis Res Ther. 2023;25 (1):12. doi: 10.1186/s13075-023-02994-z. PubMed PMID:36698198 PubMed Central PMC9875496.
  54. Ghalwash, M, Anand, V, Lou, O, Martin, F, Rewers, M, Ziegler, AG et al.. Islet autoantibody screening in at-risk adolescents to predict type 1 diabetes until young adulthood: a prospective cohort study. Lancet Child Adolesc Health. 2023;7 (4):261-268. doi: 10.1016/S2352-4642(22)00350-9. PubMed PMID:36681087 PubMed Central PMC10038928.
  55. Virtanen, AT, Haikarainen, T, Sampathkumar, P, Palmroth, M, Liukkonen, S, Liu, J et al.. Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain. Pharmaceuticals (Basel). 2023;16 (1):. doi: 10.3390/ph16010075. PubMed PMID:36678572 PubMed Central PMC9865020.
  56. Mäki-Opas, I, Hämäläinen, M, Moilanen, LJ, Sood, H, Leppänen, T, Kummola, L et al.. TRPA1 Mediates Contact Hypersensitivity Induced by 2,4-Dinitrochlorobenzene. J Invest Dermatol. 2023;143 (6):1104-1108.e4. doi: 10.1016/j.jid.2022.12.014. PubMed PMID:36634816 .
  57. Kerkhoff, Y, Azizi, L, Mykuliak, VV, Hytönen, VP, Block, S. Microfluidics-Based Force Spectroscopy Enables High-Throughput Force Experiments with Sub-Nanometer Resolution and Sub-Piconewton Sensitivity. Small. 2023;19 (14):e2206713. doi: 10.1002/smll.202206713. PubMed PMID:36631276 .
  58. Saralahti, AK, Harjula, SE, Rantapero, T, Uusi-Mäkelä, MIE, Kaasinen, M, Junno, M et al.. Characterization of the innate immune response to Streptococcus pneumoniae infection in zebrafish. PLoS Genet. 2023;19 (1):e1010586. doi: 10.1371/journal.pgen.1010586. PubMed PMID:36622851 PubMed Central PMC9858863.
  59. Wicaksono, WA, Buko, A, Kusstatscher, P, Cernava, T, Sinkkonen, A, Laitinen, OH et al.. Impact of Cultivation and Origin on the Fruit Microbiome of Apples and Blueberries and Implications for the Exposome. Microb Ecol. 2023;86 (2):973-984. doi: 10.1007/s00248-022-02157-8. PubMed PMID:36542126 PubMed Central PMC10335955.
  60. Flinkman, E, Vähätalo, I, Tuomisto, LE, Lehtimäki, L, Nieminen, P, Niemelä, O et al.. Association Between Blood Eosinophils and Neutrophils With Clinical Features in Adult-Onset Asthma. J Allergy Clin Immunol Pract. 2023;11 (3):811-821.e5. doi: 10.1016/j.jaip.2022.11.025. PubMed PMID:36473624 .
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