2023
- Lamichhane, S, Sen, P, Dickens, AM, Kråkström, M, Ilonen, J, Lempainen, J et al.. Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children. Front Endocrinol (Lausanne). 2023;14 :1211015. doi: 10.3389/fendo.2023.1211015. PubMed PMID:37745723 PubMed Central PMC10516565.
- Hirvonen, MK, Lietzén, N, Moulder, R, Bhosale, SD, Koskenniemi, J, Vähä-Mäkilä, M et al.. Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes. Sci Rep. 2023;13 (1):15941. doi: 10.1038/s41598-023-43039-4. PubMed PMID:37743383 PubMed Central PMC10518308.
- Wicaksono, WA, Cernava, T, Wassermann, B, Abdelfattah, A, Soto-Giron, MJ, Toledo, GV et al.. The edible plant microbiome: evidence for the occurrence of fruit and vegetable bacteria in the human gut. Gut Microbes. 2023;15 (2):2258565. doi: 10.1080/19490976.2023.2258565. PubMed PMID:37741805 PubMed Central PMC10519362.
- Kummola, L, González-Rodríguez, MI, Marnila, P, Nurminen, N, Salomaa, T, Hiihtola, L et al.. Comparison of the effect of autoclaved and non-autoclaved live soil exposure on the mouse immune system : Effect of soil exposure on immune system. BMC Immunol. 2023;24 (1):29. doi: 10.1186/s12865-023-00565-0. PubMed PMID:37689649 PubMed Central PMC10492337.
- Vecchio, F, Carré, A, Korenkov, D, Zhou, Z, Apaolaza, P, Tuomela, S et al.. Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses. bioRxiv. 2023; :. doi: 10.1101/2023.08.19.553954. PubMed PMID:37662376 PubMed Central PMC10473604.
- Dotsenko, V, Sioofy-Khojine, AB, Hyöty, H, Viiri, K. Human intestinal organoid models for celiac disease research. Methods Cell Biol. 2023;179 :173-193. doi: 10.1016/bs.mcb.2023.01.008. PubMed PMID:37625874 .
- Lönnrot, M, Lynch, KF, Rewers, M, Lernmark, Å, Vehik, K, Akolkar, B et al.. Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study. Diabetes Care. 2023; :. doi: 10.2337/dc23-0518. PubMed PMID:37607456 .
- Tavakoli, S, Evans, A, Oommen, OP, Creemers, L, Nandi, JB, Hilborn, J et al.. Unveiling extracellular matrix assembly: Insights and approaches through bioorthogonal chemistry. Mater Today Bio. 2023;22 :100768. doi: 10.1016/j.mtbio.2023.100768. PubMed PMID:37600348 PubMed Central PMC10432810.
- Krischer, JP, Lernmark, Å, Hagopian, WA, Rewers, MJ, McIndoe, R, Toppari, J et al.. SARS-CoV-2 – No Increased Islet Autoimmunity or Type 1 Diabetes in Teens. N Engl J Med. 2023;389 (5):474-475. doi: 10.1056/NEJMc2216477. PubMed PMID:37530831 PubMed Central PMC10481371.
- Rahikainen, R, Vester, SK, Turkki, P, Janosko, CP, Deiters, A, Hytönen, VP et al.. Visible light-induced specific protein reaction delineates early stages of cell adhesion. bioRxiv. 2023; :. doi: 10.1101/2023.07.21.549850. PubMed PMID:37503248 PubMed Central PMC10370186.
- Sáez-Llorens, X, Norero, X, Mussi-Pinhata, MM, Luciani, K, Salamanca de la Cueva, I, Díez-Domingo, J et al.. Safety and immunogenicity of a ChAd155-vectored respiratory syncytial virus vaccine in infants 6-7 months of age: a phase 1/2 randomized trial. J Infect Dis. 2023; :. doi: 10.1093/infdis/jiad271. PubMed PMID:37477875 .
- Seitz, I, Saarinen, S, Kumpula, EP, McNeale, D, Anaya-Plaza, E, Lampinen, V et al.. DNA-origami-directed virus capsid polymorphism. Nat Nanotechnol. 2023; :. doi: 10.1038/s41565-023-01443-x. PubMed PMID:37460794 .
- Laajala, M, Zwaagstra, M, Martikainen, M, Nekoua, MP, Benkahla, M, Sane, F et al.. Vemurafenib Inhibits Acute and Chronic Enterovirus Infection by Affecting Cellular Kinase Phosphatidylinositol 4-Kinase Type IIIβ. Microbiol Spectr. 2023;11 (4):e0055223. doi: 10.1128/spectrum.00552-23. PubMed PMID:37436162 PubMed Central PMC10433971.
- Lampinen, V, Gröhn, S, Soppela, S, Blazevic, V, Hytönen, VP, Hankaniemi, MM et al.. SpyTag/SpyCatcher display of influenza M2e peptide on norovirus-like particle provides stronger immunization than direct genetic fusion. Front Cell Infect Microbiol. 2023;13 :1216364. doi: 10.3389/fcimb.2023.1216364. PubMed PMID:37424789 PubMed Central PMC10323135.
- Luostarinen, S, Hämäläinen, M, Pemmari, A, Moilanen, E. The regulation of TRPA1 expression and function by Th1 and Th2-type inflammation in human A549 lung epithelial cells. Inflamm Res. 2023;72 (7):1327-1339. doi: 10.1007/s00011-023-01750-y. PubMed PMID:37386145 PubMed Central PMC10352175.
- Halonen, L, Pemmari, A, Nummenmaa, E, Hämäläinen, M, Moilanen, T, Vuolteenaho, K et al.. Human Osteoarthritic Chondrocytes Express Nineteen Different TRP-Genes-TRPA1 and TRPM8 as Potential Drug Targets. Int J Mol Sci. 2023;24 (12):. doi: 10.3390/ijms241210057. PubMed PMID:37373205 PubMed Central PMC10298562.
- Arwood, ML, Liu, Y, Harkins, SK, Weinstock, DM, Yang, L, Stevenson, KE et al.. New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation. Cell Chem Biol. 2023;30 (6):618-631.e12. doi: 10.1016/j.chembiol.2023.05.007. PubMed PMID:37290440 PubMed Central PMC10495080.
- Salomaa, T, Kummola, L, González-Rodríguez, MI, Hiihtola, L, Järvinen, TAH, Junttila, IS et al.. Low IL-13Rα1 expression on mast cells tunes them unresponsive to IL-13. J Leukoc Biol. 2023;114 (2):187-194. doi: 10.1093/jleuko/qiad065. PubMed PMID:37224625 .
- Hammarén, MM, Luukinen, H, Sillanpää, A, Remans, K, Lapouge, K, Custódio, T et al.. In vitro and ex vivo proteomics of Mycobacterium marinum biofilms and the development of biofilm-binding synthetic nanobodies. mSystems. 2023;8 (3):e0107322. doi: 10.1128/msystems.01073-22. PubMed PMID:37184670 PubMed Central PMC10308901.
- Saarikettu, J, Lehmusvaara, S, Pesu, M, Junttila, I, Partanen, J, Sipilä, P et al.. The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression. FASEB Bioadv. 2023;5 (5):183-198. doi: 10.1096/fba.2022-00115. PubMed PMID:37151849 PubMed Central PMC10158624.
- Pölläniemi, A, Virtanen, A, Silvennoinen, O, Haikarainen, T. Development of an enzyme-coupled activity assay for Janus kinase 2 inhibitor screening. SLAS Discov. 2023;28 (4):180-187. doi: 10.1016/j.slasd.2023.05.001. PubMed PMID:37149038 .
- Liu, X, Johnson, SB, Lynch, KF, Cordan, K, Pate, R, Butterworth, MD et al.. Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5- to 15-Year-Old Children Followed in the TEDDY Study. Diabetes Care. 2023;46 (7):1409-1416. doi: 10.2337/dc23-0036. PubMed PMID:37141102 PubMed Central PMC10300517.
- Virtanen, A, Palmroth, M, Liukkonen, S, Kurttila, A, Haikarainen, T, Isomäki, P et al.. Differences in JAK Isoform Selectivity Among Different Types of JAK Inhibitors Evaluated for Rheumatic Diseases Through In Vitro Profiling. Arthritis Rheumatol. 2023; :. doi: 10.1002/art.42547. PubMed PMID:37134144 .
- Bachmann, M, Su, B, Rahikainen, R, Hytönen, VP, Wu, J, Wehrle-Haller, B et al.. ConFERMing the role of talin in integrin activation and mechanosignaling. J Cell Sci. 2023;136 (8):. doi: 10.1242/jcs.260576. PubMed PMID:37078342 PubMed Central PMC10198623.
- Voor, T, Pärtel, M, Peet, A, Saare, L, Hyöty, H, Knip, M et al.. Atopic sensitization in childhood depends on the type of green area around the home in infancy. Clin Exp Allergy. 2023;53 (8):850-853. doi: 10.1111/cea.14317. PubMed PMID:37038920 .
- Muller, WJ, Madhi, SA, Seoane Nuñez, B, Baca Cots, M, Bosheva, M, Dagan, R et al.. Nirsevimab for Prevention of RSV in Term and Late-Preterm Infants. N Engl J Med. 2023;388 (16):1533-1534. doi: 10.1056/NEJMc2214773. PubMed PMID:37018470 .
- Walsh, EE, Pérez Marc, G, Zareba, AM, Falsey, AR, Jiang, Q, Patton, M et al.. Efficacy and Safety of a Bivalent RSV Prefusion F Vaccine in Older Adults. N Engl J Med. 2023;388 (16):1465-1477. doi: 10.1056/NEJMoa2213836. PubMed PMID:37018468 .
- Ojanen, MJT, Caro, FM, Aittomäki, S, Ploquin, MJ, Ortutay, Z, Pekkarinen, M et al.. FURIN regulates cytotoxic T-lymphocyte effector function and memory cell transition in mice. Eur J Immunol. 2023;53 (6):e2250246. doi: 10.1002/eji.202250246. PubMed PMID:37015057 .
- Taurio, J, Hautaniemi, EJ, Koskela, JK, Eräranta, A, Hämäläinen, M, Tikkakoski, A et al.. The characteristics of elevated blood pressure in abdominal obesity correspond to primary hypertension: a cross-sectional study. BMC Cardiovasc Disord. 2023;23 (1):161. doi: 10.1186/s12872-023-03150-w. PubMed PMID:36973671 PubMed Central PMC10045516.
- Sioofy-Khojine, AB, Lehtonen, JP, Nurminen, N, Laiho, JE, Toppari, J, Veijola, R et al.. HLA-DQ-conferred risk for type 1 diabetes does not alter neutralizing antibody response to a widely used enterovirus vaccine, the poliovirus vaccine. J Med Virol. 2023;95 (4):e28707. doi: 10.1002/jmv.28707. PubMed PMID:36971180 .
- Mahmoud, M, Juntunen, M, Adnan, A, Kummola, L, Junttila, IS, Kelloniemi, M et al.. Immunomodulatory Functions of Adipose Mesenchymal Stromal/Stem Cell Derived From Donors With Type 2 Diabetes and Obesity on CD4 T Cells. Stem Cells. 2023;41 (5):505-519. doi: 10.1093/stmcls/sxad021. PubMed PMID:36945068 PubMed Central PMC10183970.
- Roslund, MI, Parajuli, A, Hui, N, Puhakka, R, Grönroos, M, Soininen, L et al.. Skin, gut, and sand metagenomic data on placebo-controlled sandbox biodiversity intervention study. Data Brief. 2023;47 :109003. doi: 10.1016/j.dib.2023.109003. PubMed PMID:36915639 PubMed Central PMC10006422.
- Scotece, M, Hämäläinen, M, Leppänen, T, Vuolteenaho, K, Moilanen, E. MKP-1 Deficiency Exacerbates Skin Fibrosis in a Mouse Model of Scleroderma. Int J Mol Sci. 2023;24 (5):. doi: 10.3390/ijms24054668. PubMed PMID:36902103 PubMed Central PMC10002998.
- Thorsen, SU, Liu, X, Kataria, Y, Mandrup-Poulsen, T, Kaur, S, Uusitalo, U et al.. Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2023;46 (5):1014-1018. doi: 10.2337/dc22-1359. PubMed PMID:36867433 PubMed Central PMC10154662.
- Pavic, K, Gupta, N, Omella, JD, Derua, R, Aakula, A, Huhtaniemi, R et al.. Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A. Nat Commun. 2023;14 (1):1143. doi: 10.1038/s41467-023-36693-9. PubMed PMID:36854761 PubMed Central PMC9974998.
- Benfield, T, Rämet, M, Valentini, P, Seppä, I, Dagan, R, Richmond, P et al.. Safety, tolerability, and immunogenicity of V114 pneumococcal vaccine compared with PCV13 in a 2+1 regimen in healthy infants: A phase III study (PNEU-PED-EU-2). Vaccine. 2023;41 (15):2456-2465. doi: 10.1016/j.vaccine.2023.02.041. PubMed PMID:36841723 .
- Kummola, L, Salomaa, T, Ortutay, Z, Savan, R, Young, HA, Junttila, IS et al.. IL-4, IL-13 and IFN-γ -induced genes in highly purified human neutrophils. Cytokine. 2023;164 :156159. doi: 10.1016/j.cyto.2023.156159. PubMed PMID:36809715 PubMed Central PMC10331420.
- Wu, R, Mumtaz, M, Maxwell, AJ, Isaacs, SR, Laiho, JE, Rawlinson, WD et al.. Respiratory infections and type 1 diabetes: Potential roles in pathogenesis. Rev Med Virol. 2023;33 (2):e2429. doi: 10.1002/rmv.2429. PubMed PMID:36790804 .
- Tissarinen, P, Tiensuu, H, Haapalainen, AM, Määttä, TA, Ojaniemi, M, Hallman, M et al.. Elevated human placental heat shock protein 5 is associated with spontaneous preterm birth. Pediatr Res. 2023;94 (2):520-529. doi: 10.1038/s41390-023-02501-9. PubMed PMID:36788289 PubMed Central PMC9926443.
- Rangasami, VK, Asawa, K, Teramura, Y, Le Blanc, K, Nilsson, B, Hilborn, J et al.. Biomimetic polyelectrolyte coating of stem cells suppresses thrombotic activation and enhances its survival and function. Biomater Adv. 2023;147 :213331. doi: 10.1016/j.bioadv.2023.213331. PubMed PMID:36773382 .
- Koskela, K, Sauni, R, Uitti, J, Oksa, P, Moilanen, E, Hämäläinen, M et al.. An Increase in Plasma Adipsin Levels Is Associated With Higher Cumulative Dust Exposure and Airway Obstruction in Foundry Workers. J Occup Environ Med. 2023;65 (3):203-209. doi: 10.1097/JOM.0000000000002736. PubMed PMID:36730948 .
- Taurio, J, Koskela, J, Sinisalo, M, Tikkakoski, A, Niemelä, O, Hämäläinen, M et al.. Urine sodium excretion is related to extracellular water volume but not to blood pressure in 510 normotensive and never-treated hypertensive subjects. Blood Press. 2023;32 (1):2170869. doi: 10.1080/08037051.2023.2170869. PubMed PMID:36708156 .
- Mäki-Opas, I, Hämäläinen, M, Moilanen, E, Scotece, M. TRPA1 as a potential factor and drug target in scleroderma: dermal fibrosis and alternative macrophage activation are attenuated in TRPA1-deficient mice in bleomycin-induced experimental model of scleroderma. Arthritis Res Ther. 2023;25 (1):12. doi: 10.1186/s13075-023-02994-z. PubMed PMID:36698198 PubMed Central PMC9875496.
- Ghalwash, M, Anand, V, Lou, O, Martin, F, Rewers, M, Ziegler, AG et al.. Islet autoantibody screening in at-risk adolescents to predict type 1 diabetes until young adulthood: a prospective cohort study. Lancet Child Adolesc Health. 2023;7 (4):261-268. doi: 10.1016/S2352-4642(22)00350-9. PubMed PMID:36681087 PubMed Central PMC10038928.
- Virtanen, AT, Haikarainen, T, Sampathkumar, P, Palmroth, M, Liukkonen, S, Liu, J et al.. Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain. Pharmaceuticals (Basel). 2023;16 (1):. doi: 10.3390/ph16010075. PubMed PMID:36678572 PubMed Central PMC9865020.
- Mäki-Opas, I, Hämäläinen, M, Moilanen, LJ, Sood, H, Leppänen, T, Kummola, L et al.. TRPA1 Mediates Contact Hypersensitivity Induced by 2,4-Dinitrochlorobenzene. J Invest Dermatol. 2023;143 (6):1104-1108.e4. doi: 10.1016/j.jid.2022.12.014. PubMed PMID:36634816 .
- Kerkhoff, Y, Azizi, L, Mykuliak, VV, Hytönen, VP, Block, S. Microfluidics-Based Force Spectroscopy Enables High-Throughput Force Experiments with Sub-Nanometer Resolution and Sub-Piconewton Sensitivity. Small. 2023;19 (14):e2206713. doi: 10.1002/smll.202206713. PubMed PMID:36631276 .
- Saralahti, AK, Harjula, SE, Rantapero, T, Uusi-Mäkelä, MIE, Kaasinen, M, Junno, M et al.. Characterization of the innate immune response to Streptococcus pneumoniae infection in zebrafish. PLoS Genet. 2023;19 (1):e1010586. doi: 10.1371/journal.pgen.1010586. PubMed PMID:36622851 PubMed Central PMC9858863.
- Wicaksono, WA, Buko, A, Kusstatscher, P, Cernava, T, Sinkkonen, A, Laitinen, OH et al.. Impact of Cultivation and Origin on the Fruit Microbiome of Apples and Blueberries and Implications for the Exposome. Microb Ecol. 2023;86 (2):973-984. doi: 10.1007/s00248-022-02157-8. PubMed PMID:36542126 PubMed Central PMC10335955.
- Flinkman, E, Vähätalo, I, Tuomisto, LE, Lehtimäki, L, Nieminen, P, Niemelä, O et al.. Association Between Blood Eosinophils and Neutrophils With Clinical Features in Adult-Onset Asthma. J Allergy Clin Immunol Pract. 2023;11 (3):811-821.e5. doi: 10.1016/j.jaip.2022.11.025. PubMed PMID:36473624 .
- Luoma, J, Adubra, L, Ashorn, P, Ashorn, U, Bendabenda, J, Dewey, KG et al.. Association between asymptomatic infections and linear growth in 18-24-month-old Malawian children. Matern Child Nutr. 2023;19 (1):e13417. doi: 10.1111/mcn.13417. PubMed PMID:36111423 PubMed Central PMC9749610.
2022
- Koskela, K, Sauni, R, Uitti, J, Oksa, P, Moilanen, E, Hämäläinen, M et al.. An Increase in Plasma Adipsin Levels Is Associated With Higher Cumulative Dust Exposure and Airway Obstruction in Foundry Workers. J Occup Environ Med. 2023;65 (3):203-209. doi: 10.1097/JOM.0000000000002736. PubMed PMID:36730948 .
- Telliez, JB, Gadina, M, Ghoreschi, K, Silvennoinen, O, Spinelli, FR. Editorial: JAK inhibition in autoimmune and inflammatory diseases. Front Immunol. 2022;13 :1120281. doi: 10.3389/fimmu.2022.1120281. PubMed PMID:36643918 PubMed Central PMC9832019.
- Savijoki, K, San-Martin-Galindo, P, Pitkänen, K, Edelmann, M, Sillanpää, A, van der Velde, C et al.. Food-Grade Bacteria Combat Pathogens by Blocking AHL-Mediated Quorum Sensing and Biofilm Formation. Foods. 2022;12 (1):. doi: 10.3390/foods12010090. PubMed PMID:36613306 PubMed Central PMC9818890.
- Vatanen, T, Jabbar, KS, Ruohtula, T, Honkanen, J, Avila-Pacheco, J, Siljander, H et al.. Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism. Cell. 2022;185 (26):4921-4936.e15. doi: 10.1016/j.cell.2022.11.023. PubMed PMID:36563663 PubMed Central PMC9869402.
- Ryyti, R, Hämäläinen, M, Leppänen, T, Peltola, R, Moilanen, E. Phenolic Compounds Known to Be Present in Lingonberry (Vaccinium vitis-idaea L.) Enhance Macrophage Polarization towards the Anti-Inflammatory M2 Phenotype. Biomedicines. 2022;10 (12):. doi: 10.3390/biomedicines10123045. PubMed PMID:36551801 PubMed Central PMC9776286.
- Wicaksono, WA, Buko, A, Kusstatscher, P, Cernava, T, Sinkkonen, A, Laitinen, OH et al.. Impact of Cultivation and Origin on the Fruit Microbiome of Apples and Blueberries and Implications for the Exposome. Microb Ecol. 2023;86 (2):973-984. doi: 10.1007/s00248-022-02157-8. PubMed PMID:36542126 PubMed Central PMC10335955.
- Flinkman, E, Vähätalo, I, Tuomisto, LE, Lehtimäki, L, Nieminen, P, Niemelä, O et al.. Association Between Blood Eosinophils and Neutrophils With Clinical Features in Adult-Onset Asthma. J Allergy Clin Immunol Pract. 2023;11 (3):811-821.e5. doi: 10.1016/j.jaip.2022.11.025. PubMed PMID:36473624 .
- Valanne, S, Vesala, L, Maasdorp, MK, Salminen, TS, Rämet, M. The Drosophila Toll Pathway in Innate Immunity: from the Core Pathway toward Effector Functions. J Immunol. 2022;209 (10):1817-1825. doi: 10.4049/jimmunol.2200476. PubMed PMID:36426939 .
- Goult, BT, von Essen, M, Hytönen, VP. The mechanical cell – the role of force dependencies in synchronising protein interaction networks. J Cell Sci. 2022;135 (22):. doi: 10.1242/jcs.259769. PubMed PMID:36398718 PubMed Central PMC9845749.
- Huuskonen, C, Hämäläinen, M, Kivikangas, N, Paavonen, T, Moilanen, E, Mennander, A et al.. Myocardial interaction of apixaban after experimental acute volume overload. J Int Med Res. 2022;50 (11):3000605221137474. doi: 10.1177/03000605221137474. PubMed PMID:36397004 PubMed Central PMC9679347.
- Hakola, L, Oikarinen, M, Niinistö, S, Cuthbertson, D, Lehtonen, J, Puustinen, L et al.. Serum 25-hydroxyvitamin D and fatty acids in relation to the risk of microbial infections in children: The TRIGR Divia study. Clin Nutr. 2022;41 (12):2729-2739. doi: 10.1016/j.clnu.2022.10.017. PubMed PMID:36368258 .
- Laurikka, A, Vuolteenaho, K, Toikkanen, V, Rinne, T, Leppänen, T, Hämäläinen, M et al.. Inflammatory Glycoprotein YKL-40 Is Elevated after Coronary Artery Bypass Surgery and Correlates with Leukocyte Chemotaxis and Myocardial Injury, a Pilot Study. Cells. 2022;11 (21):. doi: 10.3390/cells11213378. PubMed PMID:36359773 PubMed Central PMC9653903.
- Leroux-Roels, I, Maes, C, Joye, J, Jacobs, B, Jarczowski, F, Diessner, A et al.. A randomized, double-blind, placebo-controlled, dose-escalating phase I trial to evaluate safety and immunogenicity of a plant-produced, bivalent, recombinant norovirus-like particle vaccine. Front Immunol. 2022;13 :1021500. doi: 10.3389/fimmu.2022.1021500. PubMed PMID:36275772 PubMed Central PMC9585308.
- Pemmari, T, Hämäläinen, M, Ryyti, R, Peltola, R, Moilanen, E. Dried Bilberry (Vaccinium myrtillus L.) Alleviates the Inflammation and Adverse Metabolic Effects Caused by a High-Fat Diet in a Mouse Model of Obesity. Int J Mol Sci. 2022;23 (19):. doi: 10.3390/ijms231911021. PubMed PMID:36232316 PubMed Central PMC9569776.
- Wang, S, Tavakoli, S, Parvathaneni, RP, Nawale, GN, Oommen, OP, Hilborn, J et al.. Dynamic covalent crosslinked hyaluronic acid hydrogels and nanomaterials for biomedical applications. Biomater Sci. 2022;10 (22):6399-6412. doi: 10.1039/d2bm01154a. PubMed PMID:36214100 .
- Mäki-Koivisto, V, Sinikumpu, SP, Jokelainen, J, Aho-Laukkanen, E, Junttila, IS, Huilaja, L et al.. Impact of COVID-19 Pandemic on the Incidence of Sexually Transmitted Infections in Northern Finland in 2019 to 2022. Acta Derm Venereol. 2022;102 :adv00795. doi: 10.2340/actadv.v102.3401. PubMed PMID:36200507 PubMed Central PMC9677277.
- Stone, VM, Utorova, R, Butrym, M, Sioofy-Khojine, AB, Hankaniemi, MM, Ringqvist, EE et al.. Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination. iScience. 2022;25 (10):105070. doi: 10.1016/j.isci.2022.105070. PubMed PMID:36157581 PubMed Central PMC9490033.
- Banniettis, N, Wysocki, J, Szenborn, L, Phongsamart, W, Pitisuttithum, P, Rämet, M et al.. A phase III, multicenter, randomized, double-blind, active comparator-controlled study to evaluate the safety, tolerability, and immunogenicity of catch-up vaccination regimens of V114, a 15-valent pneumococcal conjugate vaccine, in healthy infants, children, and adolescents (PNEU-PLAN). Vaccine. 2022;40 (44):6315-6325. doi: 10.1016/j.vaccine.2022.09.003. PubMed PMID:36150974 .
- Vehik, K, Boulware, D, Killian, M, Rewers, M, McIndoe, R, Toppari, J et al.. Rising Hemoglobin A1c in the Nondiabetic Range Predicts Progression of Type 1 Diabetes As Well As Oral Glucose Tolerance Tests. Diabetes Care. 2022;45 (10):2342-2349. doi: 10.2337/dc22-0828. PubMed PMID:36150054 PubMed Central PMC9587339.
- Krischer, JP, Liu, X, Lernmark, Å, Hagopian, WA, Rewers, MJ, She, JX et al.. Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study. Diabetes Care. 2022;45 (10):2271-2281. doi: 10.2337/dc21-2612. PubMed PMID:36150053 PubMed Central PMC9643148.
- Huuskonen, C, Hämäläinen, M, Kivikangas, N, Paavonen, T, Moilanen, E, Mennander, AA et al.. Early reversibility of histological changes after experimental acute cardiac volume-overload. Am J Cardiovasc Dis. 2022;12 (4):205-211. . PubMed PMID:36147786 PubMed Central PMC9490159.
- Pemmari, T, Hämäläinen, M, Ryyti, R, Peltola, R, Moilanen, E. Cloudberry (Rubus chamaemorus L.) Supplementation Attenuates the Development of Metabolic Inflammation in a High-Fat Diet Mouse Model of Obesity. Nutrients. 2022;14 (18):. doi: 10.3390/nu14183846. PubMed PMID:36145221 PubMed Central PMC9503149.
- Valli, A, Kuuliala, K, Virtanen, A, Kuuliala, A, Palmroth, M, Peltomaa, R et al.. Tofacitinib treatment modulates the levels of several inflammation-related plasma proteins in rheumatoid arthritis and baseline levels of soluble biomarkers associate with the treatment response. Clin Exp Immunol. 2022;210 (2):141-150. doi: 10.1093/cei/uxac085. PubMed PMID:36124688 PubMed Central PMC9750823.
- Luoma, J, Adubra, L, Ashorn, P, Ashorn, U, Bendabenda, J, Dewey, KG et al.. Association between asymptomatic infections and linear growth in 18-24-month-old Malawian children. Matern Child Nutr. 2023;19 (1):e13417. doi: 10.1111/mcn.13417. PubMed PMID:36111423 PubMed Central PMC9749610.
- Silvennoinen, O, Haikarainen, T, Virtanen, A. Aiming for the pocket. Nat Chem Biol. 2022;18 (12):1296-1297. doi: 10.1038/s41589-022-01120-5. PubMed PMID:36097296 .
- Wicaksono, WA, Buko, A, Kusstatscher, P, Sinkkonen, A, Laitinen, OH, Virtanen, SM et al.. Modulation of the food microbiome by apple fruit processing. Food Microbiol. 2022;108 :104103. doi: 10.1016/j.fm.2022.104103. PubMed PMID:36088117 .
- Liu, Z, Fan, YM, Ashorn, P, Chingwanda, C, Maleta, K, Hallamaa, L et al.. Lack of Associations between Environmental Exposures and Environmental Enteric Dysfunction among 18-Month-Old Children in Rural Malawi. Int J Environ Res Public Health. 2022;19 (17):. doi: 10.3390/ijerph191710891. PubMed PMID:36078607 PubMed Central PMC9517768.
- Yrjänäinen, A, Patrikainen, MS, Azizi, L, Tolvanen, MEE, Laitaoja, M, Jänis, J et al.. Biochemical and Biophysical Characterization of Carbonic Anhydrase VI from Human Milk and Saliva. Protein J. 2022;41 (4-5):489-503. doi: 10.1007/s10930-022-10070-9. PubMed PMID:35947329 PubMed Central PMC9464147.
- Roslund, MI, Parajuli, A, Hui, N, Puhakka, R, Grönroos, M, Soininen, L et al.. A Placebo-controlled double-blinded test of the biodiversity hypothesis of immune-mediated diseases: Environmental microbial diversity elicits changes in cytokines and increase in T regulatory cells in young children. Ecotoxicol Environ Saf. 2022;242 :113900. doi: 10.1016/j.ecoenv.2022.113900. PubMed PMID:35930838 .
- Sioofy-Khojine, AB, Richardson, SJ, Locke, JM, Oikarinen, S, Nurminen, N, Laine, AP et al.. Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage. Diabetologia. 2022;65 (10):1701-1709. doi: 10.1007/s00125-022-05753-y. PubMed PMID:35867130 PubMed Central PMC9477938.
- Azizi, L, Varela, L, Turkki, P, Mykuliak, VV, Korpela, S, Ihalainen, TO et al.. Talin variant P229S compromises integrin activation and associates with multifaceted clinical symptoms. Hum Mol Genet. 2022;31 (24):4159-4172. doi: 10.1093/hmg/ddac163. PubMed PMID:35861643 PubMed Central PMC9759328.
- Lehmusvaara, S, Haikarainen, T, Saarikettu, J, Martinez Nieto, G, Silvennoinen, O. Inhibition of RNA Binding in SND1 Increases the Levels of miR-1-3p and Sensitizes Cancer Cells to Navitoclax. Cancers (Basel). 2022;14 (13):. doi: 10.3390/cancers14133100. PubMed PMID:35804872 PubMed Central PMC9265050.
- Laajala, E, Kalim, UU, Grönroos, T, Rasool, O, Halla-Aho, V, Konki, M et al.. Umbilical cord blood DNA methylation in children who later develop type 1 diabetes. Diabetologia. 2022;65 (9):1534-1540. doi: 10.1007/s00125-022-05726-1. PubMed PMID:35716175 PubMed Central PMC9345803.
- Zolfaghari Emameh, R, Barker, HR, Turpeinen, H, Parkkila, S, Hytönen, VP. A reverse vaccinology approach on transmembrane carbonic anhydrases from Plasmodium species as vaccine candidates for malaria prevention. Malar J. 2022;21 (1):189. doi: 10.1186/s12936-022-04186-7. PubMed PMID:35706028 PubMed Central PMC9199335.
- Laiho, JE, Laitinen, OH, Malkamäki, J, Puustinen, L, Sinkkonen, A, Pärkkä, J et al.. Exposomic determinants of immune-mediated diseases: Special focus on type 1 diabetes, celiac disease, asthma, and allergies: The HEDIMED project approach. Environ Epidemiol. 2022;6 (3):e212. doi: 10.1097/EE9.0000000000000212. PubMed PMID:35702504 PubMed Central PMC9187189.
- Niinistö, S, Miettinen, ME, Cuthbertson, D, Honkanen, J, Hakola, L, Autio, R et al.. Associations Between Serum Fatty Acids and Immunological Markers in Children Developing Islet Autoimmunity-The TRIGR Nested Case-Control Study. Front Immunol. 2022;13 :858875. doi: 10.3389/fimmu.2022.858875. PubMed PMID:35693790 PubMed Central PMC9175567.
- Urbański, LJ, Bua, S, Angeli, A, Emameh, RZ, Barker, HR, Kuuslahti, M et al.. The production and biochemical characterization of α-carbonic anhydrase from Lactobacillus rhamnosus GG. Appl Microbiol Biotechnol. 2022;106 (11):4065-4074. doi: 10.1007/s00253-022-11990-3. PubMed PMID:35612631 PubMed Central PMC9200688.
- Samanta, S, Ylä-Outinen, L, Rangasami, VK, Narkilahti, S, Oommen, OP. Corrigendum to ‘Bidirectional cell-matrix interaction dictates neuronal network formation in a brain mimetic 3D scaffold’ [Acta Biomaterialia (2022) 314-323]. Acta Biomater. 2022;147 :439. doi: 10.1016/j.actbio.2022.05.025. PubMed PMID:35597769 .
- Niemelä, T, Kankaanranta, H, Vähätalo, I, Loponen, J, Tuomisto, LE, Niemelä, O et al.. Relationship Between Soluble Urokinase Plasminogen Activator Receptor (suPAR) and Disease Outcome in Adult-Onset Asthma. J Asthma Allergy. 2022;15 :579-593. doi: 10.2147/JAA.S356083. PubMed PMID:35592386 PubMed Central PMC9112192.
- Kopra, K, Hassan, N, Vuorinen, E, Valtonen, S, Mahran, R, Habib, H et al.. Rapid high-throughput compatible label-free virus particle quantification method based on time-resolved luminescence. Anal Bioanal Chem. 2022;414 (15):4509-4518. doi: 10.1007/s00216-022-04104-5. PubMed PMID:35581427 PubMed Central PMC9113738.
- Välikangas, T, Lietzén, N, Jaakkola, MK, Krogvold, L, Eike, MC, Kallionpää, H et al.. Pancreas Whole Tissue Transcriptomics Highlights the Role of the Exocrine Pancreas in Patients With Recently Diagnosed Type 1 Diabetes. Front Endocrinol (Lausanne). 2022;13 :861985. doi: 10.3389/fendo.2022.861985. PubMed PMID:35498413 PubMed Central PMC9044038.
- Tiensuu, H, Haapalainen, AM, Tissarinen, P, Pasanen, A, Määttä, TA, Huusko, JM et al.. Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth. BMC Med. 2022;20 (1):141. doi: 10.1186/s12916-022-02339-8. PubMed PMID:35477570 PubMed Central PMC9047282.
- Knuf, M, Rämet, M, Breinholt Stærke, N, Bertrand-Gerentes, I, Thollot, Y, B’Chir, S et al.. Comparing the meningococcal serogroup C immune response elicited by a tetanus toxoid conjugate quadrivalent meningococcal vaccine (MenACYW-TT) versus a quadrivalent or monovalent C tetanus toxoid conjugate meningococcal vaccine in healthy meningococcal vaccine-naïve toddlers: A randomised, controlled trial. Hum Vaccin Immunother. 2022;18 (5):2052657. doi: 10.1080/21645515.2022.2052657. PubMed PMID:35445641 PubMed Central PMC9225511.
- Soininen, L, Roslund, MI, Nurminen, N, Puhakka, R, Laitinen, OH, Hyöty, H et al.. Indoor green wall affects health-associated commensal skin microbiota and enhances immune regulation: a randomized trial among urban office workers. Sci Rep. 2022;12 (1):6518. doi: 10.1038/s41598-022-10432-4. PubMed PMID:35444249 PubMed Central PMC9021224.
- Piesanen, J, Valjakka, J, Niemelä, S, Borgenström, M, Nikkari, S, Hytönen, V et al.. Hepcidin is potential regulator for renin activity. PLoS One. 2022;17 (4):e0267343. doi: 10.1371/journal.pone.0267343. PubMed PMID:35442992 PubMed Central PMC9020709.
- Lehtola, T, Nummenmaa, E, Tuure, L, Hämäläinen, M, Nieminen, RM, Moilanen, T et al.. Dexamethasone Attenuates the Expression of MMP-13 in Chondrocytes through MKP-1. Int J Mol Sci. 2022;23 (7):. doi: 10.3390/ijms23073880. PubMed PMID:35409238 PubMed Central PMC8998740.
- Hård Af Segerstad, EM, Liu, X, Uusitalo, U, Agardh, D, Andrén Aronsson, C, TEDDY Study Group et al.. Sources of dietary gluten in the first 2 years of life and associations with celiac disease autoimmunity and celiac disease in Swedish genetically predisposed children: The Environmental Determinants of Diabetes in the Young (TEDDY) study. Am J Clin Nutr. 2022;116 (2):394-403. doi: 10.1093/ajcn/nqac086. PubMed PMID:35394004 PubMed Central PMC9348971.
- Lindfors, L, Sioris, P, Anttalainen, A, Korelin, K, Kontunen, A, Karjalainen, M et al.. Detection of cultured breast cancer cells from human tumor-derived matrix by differential ion mobility spectrometry. Anal Chim Acta. 2022;1202 :339659. doi: 10.1016/j.aca.2022.339659. PubMed PMID:35341512 .
- Törn, C, Liu, X, Onengut-Gumuscu, S, Counts, KM, Moreno, JL, Remedios, CL et al.. Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study. Sci Rep. 2022;12 (1):4516. doi: 10.1038/s41598-022-08058-7. PubMed PMID:35296692 PubMed Central PMC8927592.
- Li, Z, Veijola, R, Koski, E, Anand, V, Martin, F, Waugh, K et al.. Childhood Height Growth Rate Association With the Risk of Islet Autoimmunity and Development of Type 1 Diabetes. J Clin Endocrinol Metab. 2022;107 (6):1520-1528. doi: 10.1210/clinem/dgac121. PubMed PMID:35244713 PubMed Central PMC9113806.
- Domachowske, J, Madhi, SA, Simões, EAF, Atanasova, V, Cabañas, F, Furuno, K et al.. Safety of Nirsevimab for RSV in Infants with Heart or Lung Disease or Prematurity. N Engl J Med. 2022;386 (9):892-894. doi: 10.1056/NEJMc2112186. PubMed PMID:35235733 .
- Hammitt, LL, Dagan, R, Yuan, Y, Baca Cots, M, Bosheva, M, Madhi, SA et al.. Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants. N Engl J Med. 2022;386 (9):837-846. doi: 10.1056/NEJMoa2110275. PubMed PMID:35235726 .
- Archer, M, Niemelä, O, Hämäläinen, M, Moilanen, E, Leinonen, E, Kampman, O et al.. The role of alcohol use and adiposity in serum levels of IL-1RA in depressed patients. BMC Psychiatry. 2022;22 (1):158. doi: 10.1186/s12888-022-03784-8. PubMed PMID:35232419 PubMed Central PMC8889691.
- Ferrat, LA, Vehik, K, Sharp, SA, Lernmark, Å, Rewers, MJ, She, JX et al.. Author Correction: A combined risk score enhances prediction of type 1 diabetes among susceptible children. Nat Med. 2022;28 (3):599. doi: 10.1038/s41591-021-01631-z. PubMed PMID:35165454 .
- Suomi, T, Kalim, UU, Rasool, O, Laiho, A, Kallionpää, H, Vähä-Mäkilä, M et al.. Type 1 Diabetes in Children With Genetic Risk May Be Predicted Very Early With a Blood miRNA. Diabetes Care. 2022;45 (4):e77-e79. doi: 10.2337/dc21-2120. PubMed PMID:35134118 PubMed Central PMC9016735.
- Samanta, S, Rangasami, VK, Sarlus, H, Samal, JRK, Evans, AD, Parihar, VS et al.. Interpenetrating gallol functionalized tissue adhesive hyaluronic acid hydrogel polarizes macrophages to an immunosuppressive phenotype. Acta Biomater. 2022;142 :36-48. doi: 10.1016/j.actbio.2022.01.048. PubMed PMID:35085799 .
- Tusé, D, Malm, M, Tamminen, K, Diessner, A, Thieme, F, Jarczowski, F et al.. Safety and immunogenicity studies in animal models support clinical development of a bivalent norovirus-like particle vaccine produced in plants. Vaccine. 2022;40 (7):977-987. doi: 10.1016/j.vaccine.2022.01.009. PubMed PMID:35063285 .
- Jacobsen, LM, Vehik, K, Veijola, R, Warncke, K, Toppari, J, Steck, AK et al.. Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2022;45 (3):624-633. doi: 10.2337/dc21-0422. PubMed PMID:35043162 PubMed Central PMC8918232.
- Buchacher, T, Honkimaa, A, Välikangas, T, Lietzén, N, Hirvonen, MK, Laiho, JE et al.. Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells. iScience. 2022;25 (1):103653. doi: 10.1016/j.isci.2021.103653. PubMed PMID:35024587 PubMed Central PMC8728469.
- Melin, J, Lynch, KF, Lundgren, M, Aronsson, CA, Larsson, HE, Johnson, SB et al.. Is staff consistency important to parents’ satisfaction in a longitudinal study of children at risk for type 1 diabetes: the TEDDY study. BMC Endocr Disord. 2022;22 (1):19. doi: 10.1186/s12902-021-00929-w. PubMed PMID:35012530 PubMed Central PMC8744326.
- Samanta, S, Ylä-Outinen, L, Rangasami, VK, Narkilahti, S, Oommen, OP. Bidirectional cell-matrix interaction dictates neuronal network formation in a brain-mimetic 3D scaffold. Acta Biomater. 2022;140 :314-323. doi: 10.1016/j.actbio.2021.12.010. PubMed PMID:34902615 .
- Heinimäki, S, Lampinen, V, Tamminen, K, Hankaniemi, MM, Malm, M, Hytönen, VP et al.. Antigenicity and immunogenicity of HA2 and M2e influenza virus antigens conjugated to norovirus-like, VP1 capsid-based particles by the SpyTag/SpyCatcher technology. Virology. 2022;566 :89-97. doi: 10.1016/j.virol.2021.12.001. PubMed PMID:34894525 .
- González-Rodríguez, MI, Nurminen, N, Kummola, L, Laitinen, OH, Oikarinen, S, Parajuli, A et al.. Effect of inactivated nature-derived microbial composition on mouse immune system. Immun Inflamm Dis. 2022;10 (3):e579. doi: 10.1002/iid3.579. PubMed PMID:34873877 PubMed Central PMC8926502.
- Salomaa, T, Pemmari, T, Määttä, J, Kummola, L, Salonen, N, González-Rodríguez, M et al.. IL-13Rα1 Suppresses Tumor Progression in Two-Stage Skin Carcinogenesis Model by Regulating Regulatory T Cells. J Invest Dermatol. 2022;142 (6):1565-1575.e17. doi: 10.1016/j.jid.2021.11.013. PubMed PMID:34808240 .
- Walter, EB, Talaat, KR, Sabharwal, C, Gurtman, A, Lockhart, S, Paulsen, GC et al.. Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age. N Engl J Med. 2022;386 (1):35-46. doi: 10.1056/NEJMoa2116298. PubMed PMID:34752019 PubMed Central PMC8609605.
- Urbański, LJ, Angeli, A, Mykuliak, VV, Azizi, L, Kuuslahti, M, Hytönen, VP et al.. Biochemical and structural characterization of beta-carbonic anhydrase from the parasite Trichomonas vaginalis. J Mol Med (Berl). 2022;100 (1):115-124. doi: 10.1007/s00109-021-02148-1. PubMed PMID:34652457 PubMed Central PMC8724216.
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