Skip to content
VACCIM

Research Center for Vaccine Development and Immunology

Publications

2025

  1. Tavakoli, S, Kocatürkmen, A, Oommen, OP, Varghese, OP. Ultra-Fine 3D Bioprinting of Dynamic Hyaluronic Acid Hydrogel for in Vitro Modeling. Adv Mater. 2025; :e2500315. doi: 10.1002/adma.202500315. PubMed PMID:40357760 .
  2. Mäki-Opas, I, Luostarinen, S, Hämäläinen, M, Muraki, K, Moilanen, E. The Contact Allergen Methylisothiazolinone (MIT) is a Potent Activator of the TRPA1 Ion Channel. Pharmacol Res Perspect. 2025;13 (3):e70053. doi: 10.1002/prp2.70053. PubMed PMID:40329600 PubMed Central PMC12056303.
  3. Länsivaara, A, Palmroth, M, Kaarela, O, Hyöty, H, Oikarinen, S, Lehto, KM et al.. Virus detection in influent, activated sludge, and effluent from municipal wastewater treatment plants using composite and grab samples in Finland. Environ Res. 2025; :121776. doi: 10.1016/j.envres.2025.121776. PubMed PMID:40324624 .
  4. Hiitola, E, Korhonen, J, Kokkonen, H, Koskela, J, Kankainen, M, Alakuijala, M et al.. Clonal hematopoiesis is associated with distinct rheumatoid arthritis phenotypes. Sci Adv. 2025;11 (18):eadt9846. doi: 10.1126/sciadv.adt9846. PubMed PMID:40305610 PubMed Central PMC12042900.
  5. Rewers, M, Agardh, D, Johnson, SB, Bonifacio, E, Larsson, HE, Gesualdo, P et al.. Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study. Diabetes Care. 2025; :. doi: 10.2337/dc24-2886. PubMed PMID:40272272 .
  6. Martinón-Torres, F, Simko, R, Ebert, R, Rämet, M, Zocchetti, C, Syrkina, O et al.. Five-Year Immune Persistence of a Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) and Immunogenicity and Safety of a Booster Dose in Children. Infect Dis Ther. 2025; :. doi: 10.1007/s40121-025-01121-6. PubMed PMID:40169489 .
  7. Soppela, S, Plavec, Z, Gröhn, S, Mustonen, I, Jartti, M, Oikarinen, S et al.. Immunological and structural evaluation of the intranasally administrated CVB1 whole-virus and VLP vaccines. Sci Rep. 2025;15 (1):10198. doi: 10.1038/s41598-025-94656-0. PubMed PMID:40133550 PubMed Central PMC11937443.
  8. Laiho, JE, Oikarinen, S, Morfopoulou, S, Oikarinen, M, Renner, A, Depledge, D et al.. Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes. Diabetologia. 2025;68 (6):1211-1225. doi: 10.1007/s00125-025-06359-w. PubMed PMID:40095061 PubMed Central PMC12069483.
  9. Rodriguez-Calvo, T, Laiho, JE, Oikarinen, M, Akhbari, P, Flaxman, C, Worthington, T et al.. Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes. Diabetologia. 2025;68 (6):1197-1210. doi: 10.1007/s00125-025-06384-9. PubMed PMID:40090995 PubMed Central PMC12069150.
  10. Richardson, SJ, Rodriguez-Calvo, T, Laiho, JE, Kaddis, JS, Nyalwidhe, JO, Kusmartseva, I et al.. Joint analysis of the nPOD-Virus Group data: the association of enterovirus with type 1 diabetes is supported by multiple markers of infection in pancreas tissue. Diabetologia. 2025;68 (6):1226-1241. doi: 10.1007/s00125-025-06401-x. PubMed PMID:40090994 PubMed Central PMC12069141.
  11. Vecchio, F, Laiho, JE, Hyoty, H, Pugliese, A, Mallone, R. Comment on Manduchi et al. No Evidence for Persistent Enteroviral B Infection of Pancreatic Islets in Patients With Type 1 Diabetes and Prediabetes From RNA Sequencing Data. Diabetes 2024;73:1697-1704. Diabetes. 2025;74 (3):e3-e4. doi: 10.2337/db24-0809. PubMed PMID:39977614 .
  12. Roshanbinfar, K, Evans, AD, Samanta, S, Kolesnik-Gray, M, Fiedler, M, Krstic, V et al.. Enhancing biofabrication: Shrink-resistant collagen-hyaluronan composite hydrogel for tissue engineering and 3D bioprinting applications. Biomaterials. 2025;318 :123174. doi: 10.1016/j.biomaterials.2025.123174. PubMed PMID:39951830 .
  13. Walsh, EE, Eiras, D, Woodside, J, Jiang, Q, Patton, M, Marc, GP et al.. Efficacy, Immunogenicity, and Safety of the Bivalent RSV Prefusion F (RSVpreF) Vaccine in Older Adults Over 2 RSV Seasons. Clin Infect Dis. 2025; :. doi: 10.1093/cid/ciaf061. PubMed PMID:39928572 .
  14. Hummel, S, Käßl, A, Arnolds, S, Achenbach, P, Berner, R, Casteels, K et al.. Anti-viral action against type 1 diabetes autoimmunity: The GPPAD-AVAnT1A study protocol. Contemp Clin Trials Commun. 2025;44 :101434. doi: 10.1016/j.conctc.2025.101434. PubMed PMID:39916680 PubMed Central PMC11799962.
  15. Uusi-Mäkelä, M, Harjula, SE, Junno, M, Sillanpää, A, Nätkin, R, Niskanen, MT et al.. The inflammasome adaptor pycard is essential for immunity against Mycobacterium marinum infection in adult zebrafish. Dis Model Mech. 2025;18 (9):. doi: 10.1242/dmm.052061. PubMed PMID:39916610 PubMed Central PMC11972081.
  16. Koski, S, Martinon-Torres, F, Rämet, M, Zolotas, L, Newton, R, Maansson, R et al.. A Phase 3B, Open-Label Study to Evaluate the Immunogenicity and Safety of the Quadrivalent Meningococcal Nimenrix Vaccine When Given to Healthy Infants at 3 and 12 Months of Age. Infect Dis Ther. 2025;14 (2):463-481. doi: 10.1007/s40121-024-01098-8. PubMed PMID:39883399 PubMed Central PMC11829884.
  17. Mynarek, IM, Krogvold, L, Mørk, FB, Lawaetz, TWH, Roald, T, Fagerland, MW et al.. Three-Year Follow-up After Antiviral Treatment in New-Onset Type 1 Diabetes: Results From the Diabetes Virus Detection and Intervention Trial. Diabetes Care. 2025;48 (3):481-488. doi: 10.2337/dc24-2121. PubMed PMID:39804800 .
  18. Juusola, T, Aho-Laukkanen, E, Rahkonen, M, Mäki-Koivisto, V, Junttila, IS. Cryptococcal meningoencephalitis in a patient on immunomodulatory drug: A case report. J Mycol Med. 2025;35 (1):101529. doi: 10.1016/j.mycmed.2024.101529. PubMed PMID:39756269 .
  19. Virtanen, A, Kettunen, V, Musta, K, Räkköläinen, V, Knapp, S, Haikarainen, T et al.. Molecular basis of JAK kinase regulation guiding therapeutic approaches: Evaluating the JAK3 pseudokinase domain as a drug target. Adv Biol Regul. 2025;95 :101072. doi: 10.1016/j.jbior.2024.101072. PubMed PMID:39755448 .
  20. Nolan, T, Bhusal, C, Beran, J, Bloch, M, Cetin, BS, Dinleyici, EC et al.. Breadth of immune response, immunogenicity, reactogenicity, and safety for a pentavalent meningococcal ABCWY vaccine in healthy adolescents and young adults: results from a phase 3, randomised, controlled observer-blinded trial. Lancet Infect Dis. 2025;25 (5):560-573. doi: 10.1016/S1473-3099(24)00667-4. PubMed PMID:39647494 .
  21. Loponen, J, Vähätalo, I, Tuomisto, LE, Niemelä, O, Lehtimäki, L, Hämäläinen, M et al.. Physical exercise, systemic inflammation and adult-onset asthma: a 12-year follow-up study. J Asthma. 2025;62 (4):714-724. doi: 10.1080/02770903.2024.2438096. PubMed PMID:39636329 .
  22. Savolainen, LE, Peltola, J, Hilla, R, Åman, T, Broas, M, Junttila, IS et al.. Clinical performance of two commercially available rapid antigen tests for influenza, RSV, and SARS-CoV-2 diagnostics. Microbiol Spectr. 2025;13 (1):e0163024. doi: 10.1128/spectrum.01630-24. PubMed PMID:39589150 PubMed Central PMC11705943.
  23. Lernmark, Å, Agardh, D, Akolkar, B, Gesualdo, P, Hagopian, WA, Haller, MJ et al.. Looking back at the TEDDY study: lessons and future directions. Nat Rev Endocrinol. 2025;21 (3):154-165. doi: 10.1038/s41574-024-01045-0. PubMed PMID:39496810 PubMed Central PMC11825287.
  24. Marttila, S, Rajić, S, Ciantar, J, Mak, JKL, Junttila, IS, Kummola, L et al.. Biological aging of different blood cell types. Geroscience. 2025;47 (1):1075-1092. doi: 10.1007/s11357-024-01287-w. PubMed PMID:39060678 PubMed Central PMC11872950.
  25. Jonsdottir, B, Clasen, JL, Vehik, K, Lernmark, Å, Lundgren, M, Bonifacio, E et al.. Early Appearance of Thyroid Autoimmunity in Children Followed From Birth for Type 1 Diabetes Risk. J Clin Endocrinol Metab. 2025;110 (2):498-510. doi: 10.1210/clinem/dgae478. PubMed PMID:38996042 PubMed Central PMC11747670.
  26. Madhi, SA, Ceballos, A, Cousin, L, Domachowske, JB, Langley, JM, Lu, E et al.. Population Attributable Risk of Wheeze in 2-<6-Year-old Children, Following a Respiratory Syncytial Virus Lower Respiratory Tract Infection in The First 2 Years of Life. Pediatr Infect Dis J. 2025;44 (5):379-386. doi: 10.1097/INF.0000000000004447. PubMed PMID:38985986 .

Search PubMed

2024

  1. Juusola, T, Aho-Laukkanen, E, Rahkonen, M, Mäki-Koivisto, V, Junttila, IS. Cryptococcal meningoencephalitis in a patient on immunomodulatory drug: A case report. J Mycol Med. 2025;35 (1):101529. doi: 10.1016/j.mycmed.2024.101529. PubMed PMID:39756269 .
  2. Virtanen, A, Kettunen, V, Musta, K, Räkköläinen, V, Knapp, S, Haikarainen, T et al.. Molecular basis of JAK kinase regulation guiding therapeutic approaches: Evaluating the JAK3 pseudokinase domain as a drug target. Adv Biol Regul. 2025;95 :101072. doi: 10.1016/j.jbior.2024.101072. PubMed PMID:39755448 .
  3. Nolan, T, Bhusal, C, Beran, J, Bloch, M, Cetin, BS, Dinleyici, EC et al.. Breadth of immune response, immunogenicity, reactogenicity, and safety for a pentavalent meningococcal ABCWY vaccine in healthy adolescents and young adults: results from a phase 3, randomised, controlled observer-blinded trial. Lancet Infect Dis. 2024; :. doi: 10.1016/S1473-3099(24)00667-4. PubMed PMID:39647494 .
  4. Loponen, J, Vähätalo, I, Tuomisto, LE, Niemelä, O, Lehtimäki, L, Hämäläinen, M et al.. Physical exercise, systemic inflammation and adult-onset asthma: a 12-year follow-up study. J Asthma. 2024; :1-11. doi: 10.1080/02770903.2024.2438096. PubMed PMID:39636329 .
  5. Savolainen, LE, Peltola, J, Hilla, R, Åman, T, Broas, M, Junttila, IS et al.. Clinical performance of two commercially available rapid antigen tests for influenza, RSV, and SARS-CoV-2 diagnostics. Microbiol Spectr. 2025;13 (1):e0163024. doi: 10.1128/spectrum.01630-24. PubMed PMID:39589150 PubMed Central PMC11705943.
  6. Hyöty, H, Laiho, JE, Virtanen, SM. Environmental Factors in Type 1 Diabetes. Cold Spring Harb Perspect Med. 2024; :. doi: 10.1101/cshperspect.a041590. PubMed PMID:39586629 .
  7. Nolan, T, Bhusal, C, Beran, J, Bloch, M, Cetin, BS, Dinleyici, EC et al.. 4CMenB Breadth of Immune Response, Immunogenicity, and Safety: Results From a Phase 3 Randomized, Controlled, Observer Blind Study in Adolescents and Young Adults. Open Forum Infect Dis. 2024;11 (11):ofae638. doi: 10.1093/ofid/ofae638. PubMed PMID:39582508 PubMed Central PMC11584413.
  8. Tavast, IM, Solismaa, A, Lyytikäinen, LP, Mononen, N, Moilanen, E, Hämäläinen, M et al.. Leptin and leptin receptor gene polymorphisms and depression treatment response. Acta Neuropsychiatr. 2024; :1-8. doi: 10.1017/neu.2024.43. PubMed PMID:39529327 .
  9. Lernmark, Å, Agardh, D, Akolkar, B, Gesualdo, P, Hagopian, WA, Haller, MJ et al.. Looking back at the TEDDY study: lessons and future directions. Nat Rev Endocrinol. 2025;21 (3):154-165. doi: 10.1038/s41574-024-01045-0. PubMed PMID:39496810 PubMed Central PMC11825287.
  10. Kedari, A, Iheozor-Ejiofor, R, Salminen, P, Uğurlu, H, Mäkelä, AR, Levanov, L et al.. Structural insight into rabies virus neutralization revealed by an engineered antibody scaffold. Structure. 2024;32 (12):2220-2230.e4. doi: 10.1016/j.str.2024.10.002. PubMed PMID:39471803 .
  11. Eurén, A, Lynch, K, Lindfors, K, Parikh, H, Koletzko, S, Liu, E et al.. Risk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures. Sci Rep. 2024;14 (1):25463. doi: 10.1038/s41598-024-75496-w. PubMed PMID:39462122 PubMed Central PMC11567144.
  12. Lampinen, V, Ojanen, MJT, Caro, FM, Gröhn, S, Hankaniemi, MM, Pesu, M et al.. Experimental VLP vaccine displaying a furin antigen elicits production of autoantibodies and is well tolerated in mice. Nanoscale Adv. 2024;6 (24):6239-52. doi: 10.1039/d4na00483c. PubMed PMID:39430302 PubMed Central PMC11485048.
  13. Walsh, EE, Pérez Marc, G, Falsey, AR, Jiang, Q, Eiras, D, Patton, M et al.. RENOIR Trial – RSVpreF Vaccine Efficacy over Two Seasons. N Engl J Med. 2024;391 (15):1459-1460. doi: 10.1056/NEJMc2311560. PubMed PMID:39413383 .
  14. Suonsyrjä, N, Metso, S, Moilanen, E, Mustonen, J, Jaatinen, P, Pörsti, I et al.. Haemodynamics of hyperthyroidism: increased cardiac work and findings related to vasodilatation. Eur Thyroid J. 2024;13 (5):. doi: 10.1530/ETJ-24-0090. PubMed PMID:39356807 PubMed Central PMC11558968.
  15. Pemmari, A, Moilanen, E. Macrophage and chondrocyte phenotypes in inflammation. Basic Clin Pharmacol Toxicol. 2024;135 (5):537-549. doi: 10.1111/bcpt.14085. PubMed PMID:39319534 .
  16. Laiho, JE, Oikarinen, S, Morfopoulou, S, Oikarinen, M, Renner, A, Depledge, D et al.. Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes. medRxiv. 2024; :. doi: 10.1101/2024.09.11.24313112. PubMed PMID:39314969 PubMed Central PMC11419248.
  17. Parajuli, A, Mäkelä, I, Roslund, MI, Ringqvist, E, Manninen, J, Sun, Y et al.. Production, analysis, and safety assessment of a soil and plant-based natural material with microbiome- and immune-modulatory effects. Methods. 2024;231 :94-102. doi: 10.1016/j.ymeth.2024.09.011. PubMed PMID:39306218 .
  18. Pasanen, A, Karjalainen, MK, Korppi, M, Hallman, M, Rämet, M, Research Project FinnGen
    et al.. Genetic susceptibility to acute viral bronchiolitis. J Infect Dis. 2024; :. doi: 10.1093/infdis/jiae467. PubMed PMID:39299705 .
  19. Atomwise AIMS Program. Author Correction: AI is a viable alternative to high throughput screening: a 318-target study. Sci Rep. 2024;14 (1):21579. doi: 10.1038/s41598-024-70321-w. PubMed PMID:39284864PubMed Central PMC11405665.
  20. Ojwang’, V, Nwaru, BI, Hanna-Mari, T, Heli, T, Kaila, M, Ahonen, S et al.. Early-pregnancy BMI, maternal gestational weight gain, and asthma and allergic diseases in children. Pediatr Allergy Immunol. 2024;35 (9):e14240. doi: 10.1111/pai.14240. PubMed PMID:39282918 .
  21. Virtanen, A, Spinelli, FR, Telliez, JB, O’Shea, JJ, Silvennoinen, O, Gadina, M et al.. JAK inhibitor selectivity: new opportunities, better drugs?. Nat Rev Rheumatol. 2024;20 (10):649-665. doi: 10.1038/s41584-024-01153-1. PubMed PMID:39251770 .
  22. Langley, JM, Nolan, TM, Rämet, M, Richmond, PC, Rosário Filho, N, Haazen, W et al.. A Phase 1/2a Study Evaluating Safety and Immunogenicity of Ad26.RSV.preF in RSV-seronegative Toddlers Aged 12-24 Months. Open Forum Infect Dis. 2024;11 (9):ofae453. doi: 10.1093/ofid/ofae453. PubMed PMID:39220658 PubMed Central PMC11365064.
  23. Wang, X, Baster, Z, Azizi, L, Li, L, Rajfur, Z, Hytönen, VP et al.. Talin2 binds to non-muscle myosin IIa and regulates cell attachment and fibronectin secretion. Sci Rep. 2024;14 (1):20175. doi: 10.1038/s41598-024-70866-w. PubMed PMID:39215026 PubMed Central PMC11364542.
  24. Turkki, P, Chowdhury, I, Öhman, T, Azizi, L, Varjosalo, M, Hytönen, VP et al.. Tensin-2 interactomics reveals interaction with GAPDH and a phosphorylation-mediated regulatory role in glycolysis. Sci Rep. 2024;14 (1):19862. doi: 10.1038/s41598-024-65787-7. PubMed PMID:39191795 PubMed Central PMC11350193.
  25. Azizi, L, Otani, Y, Mykuliak, VV, Goult, BT, Hytönen, VP, Turkki, P et al.. Talin-1 variants associated with spontaneous coronary artery dissection (SCAD) highlight how even subtle changes in multi-functional scaffold proteins can manifest in disease. Hum Mol Genet. 2024;33 (21):1846-1857. doi: 10.1093/hmg/ddae120. PubMed PMID:39163585 PubMed Central PMC11540920.
  26. Sallomy, C, Awolade, P, Rahnasto-Rilla, M, Hämäläinen, M, Nousiainen, LP, Johansson, NG et al.. TRPA1 Inhibition Effects by 3-Phenylcoumarin Derivatives. ACS Med Chem Lett. 2024;15 (8):1221-1226. doi: 10.1021/acsmedchemlett.4c00072. PubMed PMID:39140042 PubMed Central PMC11318103.
  27. Tiensuu, H, Haapalainen, AM, Tissarinen, P, Pasanen, A, Hallman, M, Rämet, M et al.. MicroRNA expression profile in the basal plate of human placenta associates with spontaneous preterm birth. Placenta. 2024;155 :60-69. doi: 10.1016/j.placenta.2024.08.004. PubMed PMID:39137705 .
  28. Roslund, MI, Nurminen, N, Oikarinen, S, Puhakka, R, Grönroos, M, Puustinen, L et al.. Skin exposure to soil microbiota elicits changes in cell-mediated immunity to pneumococcal vaccine. Sci Rep. 2024;14 (1):18573. doi: 10.1038/s41598-024-68235-8. PubMed PMID:39127736 PubMed Central PMC11316737.
  29. Bizaki-Vallaskangas, A, Rämö, J, Sliz, E, Kivekäs, I, Willberg, T, Saarentaus, E et al.. Genome-wide association study indicates novel associations of annexin A13 to secretory and GAS2L2 with mucous otitis media. Sci Rep. 2024;14 (1):18344. doi: 10.1038/s41598-024-68781-1. PubMed PMID:39112560PubMed Central PMC11306868.
  30. Mykuliak, VV, Rahikainen, R, Ball, NJ, Bussi, G, Goult, BT, Hytönen, VP et al.. Molecular dynamics simulations reveal how vinculin refolds partially unfolded talin rod helices to stabilize them against mechanical force. PLoS Comput Biol. 2024;20 (8):e1012341. doi: 10.1371/journal.pcbi.1012341. PubMed PMID:39110765 PubMed Central PMC11333002.
  31. Clark, R, Davies, S, Labrador, J, Loubet, P, Natalini Martínez, S, Moríñigo, HM et al.. Safety and Immunogenicity of Respiratory Syncytial Virus Prefusion F Protein Vaccine when Co-administered with Adjuvanted Seasonal Quadrivalent Influenza Vaccine in Older Adults: A Phase 3 Randomized Trial. Clin Infect Dis. 2024;79 (4):1088-1098. doi: 10.1093/cid/ciae365. PubMed PMID:39099085 PubMed Central PMC11478588.
  32. Marttila, S, Rajić, S, Ciantar, J, Mak, JKL, Junttila, IS, Kummola, L et al.. Biological aging of different blood cell types. Geroscience. 2025;47 (1):1075-1092. doi: 10.1007/s11357-024-01287-w. PubMed PMID:39060678 PubMed Central PMC11872950.
  33. Jartti, M, Flodström-Tullberg, M, Hankaniemi, MM. Enteroviruses: epidemic potential, challenges and opportunities with vaccines. J Biomed Sci. 2024;31 (1):73. doi: 10.1186/s12929-024-01058-x. PubMed PMID:39010093 PubMed Central PMC11247760.
  34. Ryyti, R, Hämäläinen, M, Tolonen, T, Mäki, M, Jaakkola, M, Peltola, R et al.. Lingonberry (- L.) Skin Extract Prevents Weight Gain and Hyperglycemia in High-Fat Diet-Induced Model of Obesity in Mice. Nutrients. 2024;16 (13):. doi: 10.3390/nu16132107. PubMed PMID:38999854 PubMed Central PMC11243352.
  35. Madhi, SA, Ceballos, A, Cousin, L, Domachowske, JB, Langley, JM, Lu, E et al.. Population Attributable Risk of Wheeze in 2-<6-Year-old Children, Following a Respiratory Syncytial Virus Lower Respiratory Tract Infection in The First 2 Years of Life. Pediatr Infect Dis J. 2024; :. doi: 10.1097/INF.0000000000004447. PubMed PMID:38985986 .
  36. Soppela, S, Plavec, Z, Gröhn, S, Jartti, M, Oikarinen, S, Laajala, M et al.. Comparison of structure and immunogenicity of CVB1-VLP and inactivated CVB1 vaccine candidates. Res Sq. 2024; :. doi: 10.21203/rs.3.rs-4545395/v1. PubMed PMID:38978565 PubMed Central PMC11230480.
  37. Lampinen, V, Gröhn, S, Lehmler, N, Jartti, M, Hytönen, VP, Schubert, M et al.. Production of norovirus-, rotavirus-, and enterovirus-like particles in insect cells is simplified by plasmid-based expression. Sci Rep. 2024;14 (1):14874. doi: 10.1038/s41598-024-65316-6. PubMed PMID:38937523 PubMed Central PMC11211442.
  38. Niinistö, S, Cuthbertson, D, Miettinen, ME, Hakola, L, Nucci, A, Korhonen, TE et al.. High Concentrations of Immunoglobulin G Against Cow Milk Proteins and Frequency of Cow Milk Consumption Are Associated With the Development of Islet Autoimmunity and Type 1 Diabetes-The Trial to Reduce Insulin-dependent Diabetes Mellitus (IDDM) in the Genetically at Risk (TRIGR) Study. J Nutr. 2024;154 (8):2493-2500. doi: 10.1016/j.tjnut.2024.06.005. PubMed PMID:38906178 PubMed Central PMC11375457.
  39. Sidibé, A, Mykuliak, VV, Zhang, P, Hytönen, VP, Wu, J, Wehrle-Haller, B et al.. Acetyl-NPKY of integrin-β1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity. iScience. 2024;27 (6):110129. doi: 10.1016/j.isci.2024.110129. PubMed PMID:38904068 PubMed Central PMC11187247.
  40. Hakola, L, Lund-Blix, NA, Takkinen, HM, Tapanainen, H, Niinistö, S, Korhonen, TE et al.. Maternal gluten, cereal, and dietary fiber intake during pregnancy and lactation and the risk of islet autoimmunity and type 1 diabetes in the child. Clin Nutr ESPEN. 2024;62 :22-27. doi: 10.1016/j.clnesp.2024.05.001. PubMed PMID:38901945 .
  41. Goswami, J, Baqui, AH, Doreski, PA, Perez Marc, G, Jimenez, G, Ahmed, S et al.. Humoral Immunogenicity of mRNA-1345 RSV Vaccine in Older Adults. J Infect Dis. 2024;230 (5):e996-e1006. doi: 10.1093/infdis/jiae316. PubMed PMID:38889247 PubMed Central PMC11566230.
  42. Miao, Y, Virtanen, A, Zmajkovic, J, Hilpert, M, Skoda, RC, Silvennoinen, O et al.. Functional and Structural Characterization of Clinical-Stage Janus Kinase 2 Inhibitors Identifies Determinants for Drug Selectivity. J Med Chem. 2024;67 (12):10012-10024. doi: 10.1021/acs.jmedchem.4c00197. PubMed PMID:38843875PubMed Central PMC11215726.
  43. Evans, AD, Pournoori, N, Saksala, E, Oommen, OP. Glycosaminoglycans’ for brain health: Harnessing glycosaminoglycan based biomaterials for treating central nervous system diseases and in-vitro modeling. Biomaterials. 2024;309 :122629. doi: 10.1016/j.biomaterials.2024.122629. PubMed PMID:38797120 .
  44. Salo, TE, Hakola, L, Niinistö, S, Takkinen, HM, Ahonen, S, Puustinen, L et al.. Gut Inflammation Markers, Diet, and Risk of Islet Autoimmunity in Finnish Children – A Nested Case-Control Study. J Nutr. 2024;154 (7):2244-2254. doi: 10.1016/j.tjnut.2024.05.015. PubMed PMID:38795745 PubMed Central PMC11282497.
  45. Tissarinen, P, Tiensuu, H, Haapalainen, AM, Ronkainen, E, Laatio, L, Vääräsmäki, M et al.. Maternal serum alpha-1 antitrypsin levels in spontaneous preterm and term pregnancies. Sci Rep. 2024;14 (1):10819. doi: 10.1038/s41598-024-61206-z. PubMed PMID:38734716 PubMed Central PMC11088650.
  46. Starskaia, I, Valta, M, Pietilä, S, Suomi, T, Pahkuri, S, Kalim, UU et al.. Distinct cellular immune responses in children en route to type 1 diabetes with different first-appearing autoantibodies. Nat Commun. 2024;15 (1):3810. doi: 10.1038/s41467-024-47918-w. PubMed PMID:38714671 PubMed Central PMC11076468.
  47. Saarenpää, M, Roslund, MI, Nurminen, N, Puhakka, R, Kummola, L, Laitinen, OH et al.. Urban indoor gardening enhances immune regulation and diversifies skin microbiota – A placebo-controlled double-blinded intervention study. Environ Int. 2024;187 :108705. doi: 10.1016/j.envint.2024.108705. PubMed PMID:38688234 .
  48. Leclerc, S, Gupta, A, Ruokolainen, V, Chen, JH, Kunnas, K, Ekman, AA et al.. Progression of herpesvirus infection remodels mitochondrial organization and metabolism. PLoS Pathog. 2024;20 (4):e1011829. doi: 10.1371/journal.ppat.1011829. PubMed PMID:38620036 PubMed Central PMC11045090.
  49. Atomwise AIMS Program. AI is a viable alternative to high throughput screening: a 318-target study. Sci Rep. 2024;14 (1):7526. doi: 10.1038/s41598-024-54655-z. PubMed PMID:38565852 PubMed Central PMC10987645.
  50. Meinhardt, A, Reilly, L, Kaliakatsos, M, Abdel-Aziz, K, Alsharidah, S, Bodi, I et al.. Novel antivirals for severe enterovirus infection in immunocompromised hosts; A case series. J Infect. 2024;88 (5):106142. doi: 10.1016/j.jinf.2024.106142. PubMed PMID:38527653 .
  51. Mäenpää, N, Tiainen, L, Hämäläinen, M, Luukkaala, T, Tanner, M, Lahdenperä, O et al.. Neuropilin-1 and placental growth factor as prognostic factors in metastatic breast cancer. BMC Cancer. 2024;24 (1):331. doi: 10.1186/s12885-024-12070-7. PubMed PMID:38468231 PubMed Central PMC10929217.
  52. Abraham, BG, Haikarainen, T, Vuorio, J, Girych, M, Virtanen, AT, Kurttila, A et al.. Molecular basis of JAK2 activation in erythropoietin receptor and pathogenic JAK2 signaling. Sci Adv. 2024;10 (10):eadl2097. doi: 10.1126/sciadv.adl2097. PubMed PMID:38457493 PubMed Central PMC10923518.
  53. Vecchio, F, Carré, A, Korenkov, D, Zhou, Z, Apaolaza, P, Tuomela, S et al.. Coxsackievirus infection induces direct pancreatic β cell killing but poor antiviral CD8 T cell responses. Sci Adv. 2024;10 (10):eadl1122. doi: 10.1126/sciadv.adl1122. PubMed PMID:38446892 PubMed Central PMC10917340.
  54. Lehtola, T, Nummenmaa, E, Nieminen, R, Hämäläinen, M, Vuolteenaho, K, Moilanen, E et al.. The glucocorticoid dexamethasone alleviates allergic inflammation through a mitogen-activated protein kinase phosphatase-1-dependent mechanism in mice. Basic Clin Pharmacol Toxicol. 2024;134 (5):686-694. doi: 10.1111/bcpt.13995. PubMed PMID:38439200 .
  55. Savijoki, K, Deptula, P, Roberts, RJ, Hammarén, M, Yli-Kauhaluoma, J, Varmanen, P et al.. Revised whole genome and DNA methylome of type strain ATCC 927. Microbiol Resour Announc. 2024;13 (4):e0101623. doi: 10.1128/mra.01016-23. PubMed PMID:38415640 PubMed Central PMC11008211.
  56. Hakola, L, Mramba, LK, Uusitalo, U, Andrén Aronsson, C, Hummel, S, Niinistö, S et al.. Intake of B vitamins and the risk of developing islet autoimmunity and type 1 diabetes in the TEDDY study. Eur J Nutr. 2024;63 (4):1329-1338. doi: 10.1007/s00394-024-03346-6. PubMed PMID:38413484 PubMed Central PMC11139689.
  57. Kokko, E, Choudhary, MK, Mutanen, A, Honkonen, M, Tikkakoski, A, Koskela, JK et al.. Volume overload is a major characteristic in primary aldosteronism: a 3-year follow-up study. J Hypertens. 2024;42 (6):1057-1065. doi: 10.1097/HJH.0000000000003696. PubMed PMID:38406920 PubMed Central PMC11064919.
  58. Hyöty, H, Kääriäinen, S, Laiho, JE, Comer, GM, Tian, W, Härkönen, T et al.. Safety, tolerability and immunogenicity of PRV-101, a multivalent vaccine targeting coxsackie B viruses (CVBs) associated with type 1 diabetes: a double-blind randomised placebo-controlled Phase I trial. Diabetologia. 2024;67 (5):811-821. doi: 10.1007/s00125-024-06092-w. PubMed PMID:38369573 PubMed Central PMC10954874.
  59. Curran, D, Matthews, S, Cabrera, ES, Pérez, SN, Breva, LP, Rämet, M et al.. The respiratory syncytial virus prefusion F protein vaccine attenuates the severity of respiratory syncytial virus-associated disease in breakthrough infections in adults ≥60 years of age. Influenza Other Respir Viruses. 2024;18 (2):e13236. doi: 10.1111/irv.13236. PubMed PMID:38314063 PubMed Central PMC10837780.
  60. Sáez-Llorens, X, Norero, X, Mussi-Pinhata, MM, Luciani, K, de la Cueva, IS, Díez-Domingo, J et al.. Safety and Immunogenicity of a ChAd155-Vectored Respiratory Syncytial Virus Vaccine in Infants 6-7 Months of age: A Phase 1/2 Randomized Trial. J Infect Dis. 2024;229 (1):95-107. doi: 10.1093/infdis/jiad271. PubMed PMID:37477875 PubMed Central PMC10786261.

Search PubMed

2023

  1. Nigi, L, Laiho, JE, Hyöty, H, Dotta, F. Editorial: The contribution of viruses and innate immune system in the pathogenesis of type 1 diabetes. Front Endocrinol (Lausanne). 2023;14 :1335716. doi: 10.3389/fendo.2023.1335716. PubMed PMID:38161972 PubMed Central PMC10757338.
  2. Zapilko, V, Moisio, S, Parikka, M, Heinäniemi, M, Lohi, O. Generation of a Zebrafish Knock-In Model Recapitulating Childhood ETV6::RUNX1-Positive B-Cell Precursor Acute Lymphoblastic Leukemia. Cancers (Basel). 2023;15 (24):. doi: 10.3390/cancers15245821. PubMed PMID:38136366 PubMed Central PMC10871125.
  3. Rahikainen, R, Vester, SK, Turkki, P, Janosko, CP, Deiters, A, Hytönen, VP et al.. Visible Light-Induced Specific Protein Reaction Delineates Early Stages of Cell Adhesion. J Am Chem Soc. 2023;145 (45):24459-24465. doi: 10.1021/jacs.3c07827. PubMed PMID:38104267 PubMed Central PMC10655181.
  4. Wilson, E, Goswami, J, Baqui, AH, Doreski, PA, Perez-Marc, G, Zaman, K et al.. Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults. N Engl J Med. 2023;389 (24):2233-2244. doi: 10.1056/NEJMoa2307079. PubMed PMID:38091530 .
  5. Nygård, L, Valta, M, Laine, AP, Toppari, J, Knip, M, Veijola, R et al.. CXADR polymorphism rs6517774 modifies islet autoimmunity characteristics and exhibits sex disparity. Front Genet. 2023;14 :1248701. doi: 10.3389/fgene.2023.1248701. PubMed PMID:38028613 PubMed Central PMC10651746.
  6. Lin, J, Moradi, E, Salenius, K, Lehtipuro, S, Häkkinen, T, Laiho, JE et al.. Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection. Nat Commun. 2023;14 (1):7630. doi: 10.1038/s41467-023-42763-9. PubMed PMID:37993433 PubMed Central PMC10665402.
  7. Patrakka, O, Tuomisto, S, Pienimäki, JP, Ollikainen, J, Oksala, N, Lampinen, V et al.. Thrombus Aspirates From Patients With Acute Ischemic Stroke Are Infiltrated by Viridans Streptococci. J Am Heart Assoc. 2023;12 (22):e030639. doi: 10.1161/JAHA.123.030639. PubMed PMID:37982253 PubMed Central PMC10727284.
  8. Mäki-Koivisto, V, Korkala, M, Simola, L, Suutari-Kontio, S, Koivunen, S, Puhto, T et al.. Positive Francisella tularensis meningitis outcome despite delayed identification: a case report. Ann Clin Microbiol Antimicrob. 2023;22 (1):92. doi: 10.1186/s12941-023-00642-7. PubMed PMID:37875923 PubMed Central PMC10598999.
  9. Pasanen, A, Karjalainen, MK, FinnGen, Zhang, G, Tiensuu, H, Haapalainen, AM et al.. Meta-analysis of genome-wide association studies of gestational duration and spontaneous preterm birth identifies new maternal risk loci. PLoS Genet. 2023;19 (10):e1010982. doi: 10.1371/journal.pgen.1010982. PubMed PMID:37871108 PubMed Central PMC10621942.
  10. Krogvold, L, Mynarek, IM, Ponzi, E, Mørk, FB, Hessel, TW, Roald, T et al.. Pleconaril and ribavirin in new-onset type 1 diabetes: a phase 2 randomized trial. Nat Med. 2023;29 (11):2902-2908. doi: 10.1038/s41591-023-02576-1. PubMed PMID:37789144 PubMed Central PMC10667091.
  11. Lamichhane, S, Sen, P, Dickens, AM, Kråkström, M, Ilonen, J, Lempainen, J et al.. Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children. Front Endocrinol (Lausanne). 2023;14 :1211015. doi: 10.3389/fendo.2023.1211015. PubMed PMID:37745723 PubMed Central PMC10516565.
  12. Hirvonen, MK, Lietzén, N, Moulder, R, Bhosale, SD, Koskenniemi, J, Vähä-Mäkilä, M et al.. Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes. Sci Rep. 2023;13 (1):15941. doi: 10.1038/s41598-023-43039-4. PubMed PMID:37743383 PubMed Central PMC10518308.
  13. Wicaksono, WA, Cernava, T, Wassermann, B, Abdelfattah, A, Soto-Giron, MJ, Toledo, GV et al.. The edible plant microbiome: evidence for the occurrence of fruit and vegetable bacteria in the human gut. Gut Microbes. 2023;15 (2):2258565. doi: 10.1080/19490976.2023.2258565. PubMed PMID:37741805 PubMed Central PMC10519362.
  14. Kummola, L, González-Rodríguez, MI, Marnila, P, Nurminen, N, Salomaa, T, Hiihtola, L et al.. Comparison of the effect of autoclaved and non-autoclaved live soil exposure on the mouse immune system : Effect of soil exposure on immune system. BMC Immunol. 2023;24 (1):29. doi: 10.1186/s12865-023-00565-0. PubMed PMID:37689649 PubMed Central PMC10492337.
  15. Vecchio, F, Carré, A, Korenkov, D, Zhou, Z, Apaolaza, P, Tuomela, S et al.. Coxsackievirus infection induces direct pancreatic β-cell killing but poor anti-viral CD8+ T-cell responses. bioRxiv. 2023; :. doi: 10.1101/2023.08.19.553954. PubMed PMID:37662376 PubMed Central PMC10473604.
  16. Dotsenko, V, Sioofy-Khojine, AB, Hyöty, H, Viiri, K. Human intestinal organoid models for celiac disease research. Methods Cell Biol. 2023;179 :173-193. doi: 10.1016/bs.mcb.2023.01.008. PubMed PMID:37625874 .
  17. Lönnrot, M, Lynch, KF, Rewers, M, Lernmark, Å, Vehik, K, Akolkar, B et al.. Gastrointestinal Infections Modulate the Risk for Insulin Autoantibodies as the First-Appearing Autoantibody in the TEDDY Study. Diabetes Care. 2023;46 (11):1908-1915. doi: 10.2337/dc23-0518. PubMed PMID:37607456 PubMed Central PMC10620548.
  18. Tavakoli, S, Evans, A, Oommen, OP, Creemers, L, Nandi, JB, Hilborn, J et al.. Unveiling extracellular matrix assembly: Insights and approaches through bioorthogonal chemistry. Mater Today Bio. 2023;22 :100768. doi: 10.1016/j.mtbio.2023.100768. PubMed PMID:37600348 PubMed Central PMC10432810.
  19. Uusitalo, U, Mramba, LK, Aronsson, CA, Vehik, K, Yang, J, Hummel, S et al.. HLA Genotype and Probiotics Modify the Association Between Timing of Solid Food Introduction and Islet Autoimmunity in the TEDDY Study. Diabetes Care. 2023;46 (10):1839-1847. doi: 10.2337/dc23-0417. PubMed PMID:37579501 PubMed Central PMC10516243.
  20. Krischer, JP, Lernmark, Å, Hagopian, WA, Rewers, MJ, McIndoe, R, Toppari, J et al.. SARS-CoV-2 – No Increased Islet Autoimmunity or Type 1 Diabetes in Teens. N Engl J Med. 2023;389 (5):474-475. doi: 10.1056/NEJMc2216477. PubMed PMID:37530831 PubMed Central PMC10481371.
  21. Rahikainen, R, Vester, SK, Turkki, P, Janosko, CP, Deiters, A, Hytönen, VP et al.. Visible light-induced specific protein reaction delineates early stages of cell adhesion. bioRxiv. 2023; :. doi: 10.1101/2023.07.21.549850. PubMed PMID:37503248 PubMed Central PMC10370186.
  22. Seitz, I, Saarinen, S, Kumpula, EP, McNeale, D, Anaya-Plaza, E, Lampinen, V et al.. DNA-origami-directed virus capsid polymorphism. Nat Nanotechnol. 2023;18 (10):1205-1212. doi: 10.1038/s41565-023-01443-x. PubMed PMID:37460794 PubMed Central PMC10575778.
  23. Laajala, M, Zwaagstra, M, Martikainen, M, Nekoua, MP, Benkahla, M, Sane, F et al.. Vemurafenib Inhibits Acute and Chronic Enterovirus Infection by Affecting Cellular Kinase Phosphatidylinositol 4-Kinase Type IIIβ. Microbiol Spectr. 2023;11 (4):e0055223. doi: 10.1128/spectrum.00552-23. PubMed PMID:37436162 PubMed Central PMC10433971.
  24. Lampinen, V, Gröhn, S, Soppela, S, Blazevic, V, Hytönen, VP, Hankaniemi, MM et al.. SpyTag/SpyCatcher display of influenza M2e peptide on norovirus-like particle provides stronger immunization than direct genetic fusion. Front Cell Infect Microbiol. 2023;13 :1216364. doi: 10.3389/fcimb.2023.1216364. PubMed PMID:37424789 PubMed Central PMC10323135.
  25. Luostarinen, S, Hämäläinen, M, Pemmari, A, Moilanen, E. The regulation of TRPA1 expression and function by Th1 and Th2-type inflammation in human A549 lung epithelial cells. Inflamm Res. 2023;72 (7):1327-1339. doi: 10.1007/s00011-023-01750-y. PubMed PMID:37386145 PubMed Central PMC10352175.
  26. Halonen, L, Pemmari, A, Nummenmaa, E, Hämäläinen, M, Moilanen, T, Vuolteenaho, K et al.. Human Osteoarthritic Chondrocytes Express Nineteen Different TRP-Genes-TRPA1 and TRPM8 as Potential Drug Targets. Int J Mol Sci. 2023;24 (12):. doi: 10.3390/ijms241210057. PubMed PMID:37373205 PubMed Central PMC10298562.
  27. Arwood, ML, Liu, Y, Harkins, SK, Weinstock, DM, Yang, L, Stevenson, KE et al.. New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation. Cell Chem Biol. 2023;30 (6):618-631.e12. doi: 10.1016/j.chembiol.2023.05.007. PubMed PMID:37290440 PubMed Central PMC10495080.
  28. Salomaa, T, Kummola, L, González-Rodríguez, MI, Hiihtola, L, Järvinen, TAH, Junttila, IS et al.. Low IL-13Rα1 expression on mast cells tunes them unresponsive to IL-13. J Leukoc Biol. 2023;114 (2):187-194. doi: 10.1093/jleuko/qiad065. PubMed PMID:37224625 .
  29. Hammarén, MM, Luukinen, H, Sillanpää, A, Remans, K, Lapouge, K, Custódio, T et al.. and proteomics of biofilms and the development of biofilm-binding synthetic nanobodies. mSystems. 2023;8 (3):e0107322. doi: 10.1128/msystems.01073-22. PubMed PMID:37184670 PubMed Central PMC10308901.
  30. Saarikettu, J, Lehmusvaara, S, Pesu, M, Junttila, I, Partanen, J, Sipilä, P et al.. The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression. FASEB Bioadv. 2023;5 (5):183-198. doi: 10.1096/fba.2022-00115. PubMed PMID:37151849 PubMed Central PMC10158624.
  31. Pölläniemi, A, Virtanen, A, Silvennoinen, O, Haikarainen, T. Development of an enzyme-coupled activity assay for Janus kinase 2 inhibitor screening. SLAS Discov. 2023;28 (4):180-187. doi: 10.1016/j.slasd.2023.05.001. PubMed PMID:37149038 .
  32. Liu, X, Johnson, SB, Lynch, KF, Cordan, K, Pate, R, Butterworth, MD et al.. Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5- to 15-Year-Old Children Followed in the TEDDY Study. Diabetes Care. 2023;46 (7):1409-1416. doi: 10.2337/dc23-0036. PubMed PMID:37141102 PubMed Central PMC10300517.
  33. Virtanen, A, Palmroth, M, Liukkonen, S, Kurttila, A, Haikarainen, T, Isomäki, P et al.. Differences in JAK Isoform Selectivity Among Different Types of JAK Inhibitors Evaluated for Rheumatic Diseases Through In Vitro Profiling. Arthritis Rheumatol. 2023;75 (11):2054-2061. doi: 10.1002/art.42547. PubMed PMID:37134144 .
  34. Bachmann, M, Su, B, Rahikainen, R, Hytönen, VP, Wu, J, Wehrle-Haller, B et al.. ConFERMing the role of talin in integrin activation and mechanosignaling. J Cell Sci. 2023;136 (8):. doi: 10.1242/jcs.260576. PubMed PMID:37078342 PubMed Central PMC10198623.
  35. Voor, T, Pärtel, M, Peet, A, Saare, L, Hyöty, H, Knip, M et al.. Atopic sensitization in childhood depends on the type of green area around the home in infancy. Clin Exp Allergy. 2023;53 (8):850-853. doi: 10.1111/cea.14317. PubMed PMID:37038920 .
  36. Muller, WJ, Madhi, SA, Seoane Nuñez, B, Baca Cots, M, Bosheva, M, Dagan, R et al.. Nirsevimab for Prevention of RSV in Term and Late-Preterm Infants. N Engl J Med. 2023;388 (16):1533-1534. doi: 10.1056/NEJMc2214773. PubMed PMID:37018470 .
  37. Walsh, EE, Pérez Marc, G, Zareba, AM, Falsey, AR, Jiang, Q, Patton, M et al.. Efficacy and Safety of a Bivalent RSV Prefusion F Vaccine in Older Adults. N Engl J Med. 2023;388 (16):1465-1477. doi: 10.1056/NEJMoa2213836. PubMed PMID:37018468 .
  38. Ojanen, MJT, Caro, FM, Aittomäki, S, Ploquin, MJ, Ortutay, Z, Pekkarinen, M et al.. FURIN regulates cytotoxic T-lymphocyte effector function and memory cell transition in mice. Eur J Immunol. 2023;53 (6):e2250246. doi: 10.1002/eji.202250246. PubMed PMID:37015057 .
  39. Taurio, J, Hautaniemi, EJ, Koskela, JK, Eräranta, A, Hämäläinen, M, Tikkakoski, A et al.. The characteristics of elevated blood pressure in abdominal obesity correspond to primary hypertension: a cross-sectional study. BMC Cardiovasc Disord. 2023;23 (1):161. doi: 10.1186/s12872-023-03150-w. PubMed PMID:36973671 PubMed Central PMC10045516.
  40. Sioofy-Khojine, AB, Lehtonen, JP, Nurminen, N, Laiho, JE, Toppari, J, Veijola, R et al.. HLA-DQ-conferred risk for type 1 diabetes does not alter neutralizing antibody response to a widely used enterovirus vaccine, the poliovirus vaccine. J Med Virol. 2023;95 (4):e28707. doi: 10.1002/jmv.28707. PubMed PMID:36971180 .
  41. Mahmoud, M, Juntunen, M, Adnan, A, Kummola, L, Junttila, IS, Kelloniemi, M et al.. Immunomodulatory Functions of Adipose Mesenchymal Stromal/Stem Cell Derived From Donors With Type 2 Diabetes and Obesity on CD4 T Cells. Stem Cells. 2023;41 (5):505-519. doi: 10.1093/stmcls/sxad021. PubMed PMID:36945068 PubMed Central PMC10183970.
  42. Roslund, MI, Parajuli, A, Hui, N, Puhakka, R, Grönroos, M, Soininen, L et al.. Skin, gut, and sand metagenomic data on placebo-controlled sandbox biodiversity intervention study. Data Brief. 2023;47 :109003. doi: 10.1016/j.dib.2023.109003. PubMed PMID:36915639 PubMed Central PMC10006422.
  43. Scotece, M, Hämäläinen, M, Leppänen, T, Vuolteenaho, K, Moilanen, E. MKP-1 Deficiency Exacerbates Skin Fibrosis in a Mouse Model of Scleroderma. Int J Mol Sci. 2023;24 (5):. doi: 10.3390/ijms24054668. PubMed PMID:36902103 PubMed Central PMC10002998.
  44. Thorsen, SU, Liu, X, Kataria, Y, Mandrup-Poulsen, T, Kaur, S, Uusitalo, U et al.. Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2023;46 (5):1014-1018. doi: 10.2337/dc22-1359. PubMed PMID:36867433 PubMed Central PMC10154662.
  45. Pavic, K, Gupta, N, Omella, JD, Derua, R, Aakula, A, Huhtaniemi, R et al.. Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A. Nat Commun. 2023;14 (1):1143. doi: 10.1038/s41467-023-36693-9. PubMed PMID:36854761 PubMed Central PMC9974998.
  46. Benfield, T, Rämet, M, Valentini, P, Seppä, I, Dagan, R, Richmond, P et al.. Safety, tolerability, and immunogenicity of V114 pneumococcal vaccine compared with PCV13 in a 2+1 regimen in healthy infants: A phase III study (PNEU-PED-EU-2). Vaccine. 2023;41 (15):2456-2465. doi: 10.1016/j.vaccine.2023.02.041. PubMed PMID:36841723 .
  47. Kummola, L, Salomaa, T, Ortutay, Z, Savan, R, Young, HA, Junttila, IS et al.. IL-4, IL-13 and IFN-γ -induced genes in highly purified human neutrophils. Cytokine. 2023;164 :156159. doi: 10.1016/j.cyto.2023.156159. PubMed PMID:36809715 PubMed Central PMC10331420.
  48. Wu, R, Mumtaz, M, Maxwell, AJ, Isaacs, SR, Laiho, JE, Rawlinson, WD et al.. Respiratory infections and type 1 diabetes: Potential roles in pathogenesis. Rev Med Virol. 2023;33 (2):e2429. doi: 10.1002/rmv.2429. PubMed PMID:36790804 PubMed Central PMC10909571.
  49. Tissarinen, P, Tiensuu, H, Haapalainen, AM, Määttä, TA, Ojaniemi, M, Hallman, M et al.. Elevated human placental heat shock protein 5 is associated with spontaneous preterm birth. Pediatr Res. 2023;94 (2):520-529. doi: 10.1038/s41390-023-02501-9. PubMed PMID:36788289 PubMed Central PMC9926443.
  50. Rangasami, VK, Asawa, K, Teramura, Y, Le Blanc, K, Nilsson, B, Hilborn, J et al.. Biomimetic polyelectrolyte coating of stem cells suppresses thrombotic activation and enhances its survival and function. Biomater Adv. 2023;147 :213331. doi: 10.1016/j.bioadv.2023.213331. PubMed PMID:36773382 .
  51. Koskela, K, Sauni, R, Uitti, J, Oksa, P, Moilanen, E, Hämäläinen, M et al.. An Increase in Plasma Adipsin Levels Is Associated With Higher Cumulative Dust Exposure and Airway Obstruction in Foundry Workers. J Occup Environ Med. 2023;65 (3):203-209. doi: 10.1097/JOM.0000000000002736. PubMed PMID:36730948 .
  52. Taurio, J, Koskela, J, Sinisalo, M, Tikkakoski, A, Niemelä, O, Hämäläinen, M et al.. Urine sodium excretion is related to extracellular water volume but not to blood pressure in 510 normotensive and never-treated hypertensive subjects. Blood Press. 2023;32 (1):2170869. doi: 10.1080/08037051.2023.2170869. PubMed PMID:36708156 .
  53. Mäki-Opas, I, Hämäläinen, M, Moilanen, E, Scotece, M. TRPA1 as a potential factor and drug target in scleroderma: dermal fibrosis and alternative macrophage activation are attenuated in TRPA1-deficient mice in bleomycin-induced experimental model of scleroderma. Arthritis Res Ther. 2023;25 (1):12. doi: 10.1186/s13075-023-02994-z. PubMed PMID:36698198 PubMed Central PMC9875496.
  54. Ghalwash, M, Anand, V, Lou, O, Martin, F, Rewers, M, Ziegler, AG et al.. Islet autoantibody screening in at-risk adolescents to predict type 1 diabetes until young adulthood: a prospective cohort study. Lancet Child Adolesc Health. 2023;7 (4):261-268. doi: 10.1016/S2352-4642(22)00350-9. PubMed PMID:36681087 PubMed Central PMC10038928.
  55. Virtanen, AT, Haikarainen, T, Sampathkumar, P, Palmroth, M, Liukkonen, S, Liu, J et al.. Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain. Pharmaceuticals (Basel). 2023;16 (1):. doi: 10.3390/ph16010075. PubMed PMID:36678572 PubMed Central PMC9865020.
  56. Mäki-Opas, I, Hämäläinen, M, Moilanen, LJ, Sood, H, Leppänen, T, Kummola, L et al.. TRPA1 Mediates Contact Hypersensitivity Induced by 2,4-Dinitrochlorobenzene. J Invest Dermatol. 2023;143 (6):1104-1108.e4. doi: 10.1016/j.jid.2022.12.014. PubMed PMID:36634816 .
  57. Kerkhoff, Y, Azizi, L, Mykuliak, VV, Hytönen, VP, Block, S. Microfluidics-Based Force Spectroscopy Enables High-Throughput Force Experiments with Sub-Nanometer Resolution and Sub-Piconewton Sensitivity. Small. 2023;19 (14):e2206713. doi: 10.1002/smll.202206713. PubMed PMID:36631276 .
  58. Saralahti, AK, Harjula, SE, Rantapero, T, Uusi-Mäkelä, MIE, Kaasinen, M, Junno, M et al.. Characterization of the innate immune response to Streptococcus pneumoniae infection in zebrafish. PLoS Genet. 2023;19 (1):e1010586. doi: 10.1371/journal.pgen.1010586. PubMed PMID:36622851 PubMed Central PMC9858863.
  59. Wicaksono, WA, Buko, A, Kusstatscher, P, Cernava, T, Sinkkonen, A, Laitinen, OH et al.. Impact of Cultivation and Origin on the Fruit Microbiome of Apples and Blueberries and Implications for the Exposome. Microb Ecol. 2023;86 (2):973-984. doi: 10.1007/s00248-022-02157-8. PubMed PMID:36542126 PubMed Central PMC10335955.
  60. Flinkman, E, Vähätalo, I, Tuomisto, LE, Lehtimäki, L, Nieminen, P, Niemelä, O et al.. Association Between Blood Eosinophils and Neutrophils With Clinical Features in Adult-Onset Asthma. J Allergy Clin Immunol Pract. 2023;11 (3):811-821.e5. doi: 10.1016/j.jaip.2022.11.025. PubMed PMID:36473624 .
  61. Luoma, J, Adubra, L, Ashorn, P, Ashorn, U, Bendabenda, J, Dewey, KG et al.. Association between asymptomatic infections and linear growth in 18-24-month-old Malawian children. Matern Child Nutr. 2023;19 (1):e13417. doi: 10.1111/mcn.13417. PubMed PMID:36111423 PubMed Central PMC9749610.

Search PubMed

2022

  1. Koskela, K, Sauni, R, Uitti, J, Oksa, P, Moilanen, E, Hämäläinen, M et al.. An Increase in Plasma Adipsin Levels Is Associated With Higher Cumulative Dust Exposure and Airway Obstruction in Foundry Workers. J Occup Environ Med. 2023;65 (3):203-209. doi: 10.1097/JOM.0000000000002736. PubMed PMID:36730948 .
  2. Telliez, JB, Gadina, M, Ghoreschi, K, Silvennoinen, O, Spinelli, FR. Editorial: JAK inhibition in autoimmune and inflammatory diseases. Front Immunol. 2022;13 :1120281. doi: 10.3389/fimmu.2022.1120281. PubMed PMID:36643918 PubMed Central PMC9832019.
  3. Savijoki, K, San-Martin-Galindo, P, Pitkänen, K, Edelmann, M, Sillanpää, A, van der Velde, C et al.. Food-Grade Bacteria Combat Pathogens by Blocking AHL-Mediated Quorum Sensing and Biofilm Formation. Foods. 2022;12 (1):. doi: 10.3390/foods12010090. PubMed PMID:36613306 PubMed Central PMC9818890.
  4. Vatanen, T, Jabbar, KS, Ruohtula, T, Honkanen, J, Avila-Pacheco, J, Siljander, H et al.. Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism. Cell. 2022;185 (26):4921-4936.e15. doi: 10.1016/j.cell.2022.11.023. PubMed PMID:36563663 PubMed Central PMC9869402.
  5. Ryyti, R, Hämäläinen, M, Leppänen, T, Peltola, R, Moilanen, E. Phenolic Compounds Known to Be Present in Lingonberry ( L.) Enhance Macrophage Polarization towards the Anti-Inflammatory M2 Phenotype. Biomedicines. 2022;10 (12):. doi: 10.3390/biomedicines10123045. PubMed PMID:36551801 PubMed Central PMC9776286.
  6. Wicaksono, WA, Buko, A, Kusstatscher, P, Cernava, T, Sinkkonen, A, Laitinen, OH et al.. Impact of Cultivation and Origin on the Fruit Microbiome of Apples and Blueberries and Implications for the Exposome. Microb Ecol. 2023;86 (2):973-984. doi: 10.1007/s00248-022-02157-8. PubMed PMID:36542126 PubMed Central PMC10335955.
  7. Flinkman, E, Vähätalo, I, Tuomisto, LE, Lehtimäki, L, Nieminen, P, Niemelä, O et al.. Association Between Blood Eosinophils and Neutrophils With Clinical Features in Adult-Onset Asthma. J Allergy Clin Immunol Pract. 2023;11 (3):811-821.e5. doi: 10.1016/j.jaip.2022.11.025. PubMed PMID:36473624 .
  8. Valanne, S, Vesala, L, Maasdorp, MK, Salminen, TS, Rämet, M. The Drosophila Toll Pathway in Innate Immunity: from the Core Pathway toward Effector Functions. J Immunol. 2022;209 (10):1817-1825. doi: 10.4049/jimmunol.2200476. PubMed PMID:36426939 .
  9. Goult, BT, von Essen, M, Hytönen, VP. The mechanical cell – the role of force dependencies in synchronising protein interaction networks. J Cell Sci. 2022;135 (22):. doi: 10.1242/jcs.259769. PubMed PMID:36398718 PubMed Central PMC9845749.
  10. Huuskonen, C, Hämäläinen, M, Kivikangas, N, Paavonen, T, Moilanen, E, Mennander, A et al.. Myocardial interaction of apixaban after experimental acute volume overload. J Int Med Res. 2022;50 (11):3000605221137474. doi: 10.1177/03000605221137474. PubMed PMID:36397004 PubMed Central PMC9679347.
  11. Hakola, L, Oikarinen, M, Niinistö, S, Cuthbertson, D, Lehtonen, J, Puustinen, L et al.. Serum 25-hydroxyvitamin D and fatty acids in relation to the risk of microbial infections in children: The TRIGR Divia study. Clin Nutr. 2022;41 (12):2729-2739. doi: 10.1016/j.clnu.2022.10.017. PubMed PMID:36368258 .
  12. Laurikka, A, Vuolteenaho, K, Toikkanen, V, Rinne, T, Leppänen, T, Hämäläinen, M et al.. Inflammatory Glycoprotein YKL-40 Is Elevated after Coronary Artery Bypass Surgery and Correlates with Leukocyte Chemotaxis and Myocardial Injury, a Pilot Study. Cells. 2022;11 (21):. doi: 10.3390/cells11213378. PubMed PMID:36359773 PubMed Central PMC9653903.
  13. Leroux-Roels, I, Maes, C, Joye, J, Jacobs, B, Jarczowski, F, Diessner, A et al.. A randomized, double-blind, placebo-controlled, dose-escalating phase I trial to evaluate safety and immunogenicity of a plant-produced, bivalent, recombinant norovirus-like particle vaccine. Front Immunol. 2022;13 :1021500. doi: 10.3389/fimmu.2022.1021500. PubMed PMID:36275772 PubMed Central PMC9585308.
  14. Pemmari, T, Hämäläinen, M, Ryyti, R, Peltola, R, Moilanen, E. Dried Bilberry ( L.) Alleviates the Inflammation and Adverse Metabolic Effects Caused by a High-Fat Diet in a Mouse Model of Obesity. Int J Mol Sci. 2022;23 (19):. doi: 10.3390/ijms231911021. PubMed PMID:36232316 PubMed Central PMC9569776.
  15. Wang, S, Tavakoli, S, Parvathaneni, RP, Nawale, GN, Oommen, OP, Hilborn, J et al.. Dynamic covalent crosslinked hyaluronic acid hydrogels and nanomaterials for biomedical applications. Biomater Sci. 2022;10 (22):6399-6412. doi: 10.1039/d2bm01154a. PubMed PMID:36214100 .
  16. Mäki-Koivisto, V, Sinikumpu, SP, Jokelainen, J, Aho-Laukkanen, E, Junttila, IS, Huilaja, L et al.. Impact of COVID-19 Pandemic on the Incidence of Sexually Transmitted Infections in Northern Finland in 2019 to 2022. Acta Derm Venereol. 2022;102 :adv00795. doi: 10.2340/actadv.v102.3401. PubMed PMID:36200507 PubMed Central PMC9677277.
  17. Stone, VM, Utorova, R, Butrym, M, Sioofy-Khojine, AB, Hankaniemi, MM, Ringqvist, EE et al.. Coxsackievirus B infections are common in Cystic Fibrosis and experimental evidence supports protection by vaccination. iScience. 2022;25 (10):105070. doi: 10.1016/j.isci.2022.105070. PubMed PMID:36157581 PubMed Central PMC9490033.
  18. Banniettis, N, Wysocki, J, Szenborn, L, Phongsamart, W, Pitisuttithum, P, Rämet, M et al.. A phase III, multicenter, randomized, double-blind, active comparator-controlled study to evaluate the safety, tolerability, and immunogenicity of catch-up vaccination regimens of V114, a 15-valent pneumococcal conjugate vaccine, in healthy infants, children, and adolescents (PNEU-PLAN). Vaccine. 2022;40 (44):6315-6325. doi: 10.1016/j.vaccine.2022.09.003. PubMed PMID:36150974 .
  19. Vehik, K, Boulware, D, Killian, M, Rewers, M, McIndoe, R, Toppari, J et al.. Rising Hemoglobin A1c in the Nondiabetic Range Predicts Progression of Type 1 Diabetes As Well As Oral Glucose Tolerance Tests. Diabetes Care. 2022;45 (10):2342-2349. doi: 10.2337/dc22-0828. PubMed PMID:36150054 PubMed Central PMC9587339.
  20. Krischer, JP, Liu, X, Lernmark, Å, Hagopian, WA, Rewers, MJ, She, JX et al.. Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study. Diabetes Care. 2022;45 (10):2271-2281. doi: 10.2337/dc21-2612. PubMed PMID:36150053 PubMed Central PMC9643148.
  21. Huuskonen, C, Hämäläinen, M, Kivikangas, N, Paavonen, T, Moilanen, E, Mennander, AA et al.. Early reversibility of histological changes after experimental acute cardiac volume-overload. Am J Cardiovasc Dis. 2022;12 (4):205-211. . PubMed PMID:36147786 PubMed Central PMC9490159.
  22. Pemmari, T, Hämäläinen, M, Ryyti, R, Peltola, R, Moilanen, E. Cloudberry ( L.) Supplementation Attenuates the Development of Metabolic Inflammation in a High-Fat Diet Mouse Model of Obesity. Nutrients. 2022;14 (18):. doi: 10.3390/nu14183846. PubMed PMID:36145221 PubMed Central PMC9503149.
  23. Valli, A, Kuuliala, K, Virtanen, A, Kuuliala, A, Palmroth, M, Peltomaa, R et al.. Tofacitinib treatment modulates the levels of several inflammation-related plasma proteins in rheumatoid arthritis and baseline levels of soluble biomarkers associate with the treatment response. Clin Exp Immunol. 2022;210 (2):141-150. doi: 10.1093/cei/uxac085. PubMed PMID:36124688 PubMed Central PMC9750823.
  24. Luoma, J, Adubra, L, Ashorn, P, Ashorn, U, Bendabenda, J, Dewey, KG et al.. Association between asymptomatic infections and linear growth in 18-24-month-old Malawian children. Matern Child Nutr. 2023;19 (1):e13417. doi: 10.1111/mcn.13417. PubMed PMID:36111423 PubMed Central PMC9749610.
  25. Silvennoinen, O, Haikarainen, T, Virtanen, A. Aiming for the pocket. Nat Chem Biol. 2022;18 (12):1296-1297. doi: 10.1038/s41589-022-01120-5. PubMed PMID:36097296 .
  26. Wicaksono, WA, Buko, A, Kusstatscher, P, Sinkkonen, A, Laitinen, OH, Virtanen, SM et al.. Modulation of the food microbiome by apple fruit processing. Food Microbiol. 2022;108 :104103. doi: 10.1016/j.fm.2022.104103. PubMed PMID:36088117 .
  27. Liu, Z, Fan, YM, Ashorn, P, Chingwanda, C, Maleta, K, Hallamaa, L et al.. Lack of Associations between Environmental Exposures and Environmental Enteric Dysfunction among 18-Month-Old Children in Rural Malawi. Int J Environ Res Public Health. 2022;19 (17):. doi: 10.3390/ijerph191710891. PubMed PMID:36078607 PubMed Central PMC9517768.
  28. Yrjänäinen, A, Patrikainen, MS, Azizi, L, Tolvanen, MEE, Laitaoja, M, Jänis, J et al.. Biochemical and Biophysical Characterization of Carbonic Anhydrase VI from Human Milk and Saliva. Protein J. 2022;41 (4-5):489-503. doi: 10.1007/s10930-022-10070-9. PubMed PMID:35947329 PubMed Central PMC9464147.
  29. Roslund, MI, Parajuli, A, Hui, N, Puhakka, R, Grönroos, M, Soininen, L et al.. A Placebo-controlled double-blinded test of the biodiversity hypothesis of immune-mediated diseases: Environmental microbial diversity elicits changes in cytokines and increase in T regulatory cells in young children. Ecotoxicol Environ Saf. 2022;242 :113900. doi: 10.1016/j.ecoenv.2022.113900. PubMed PMID:35930838 .
  30. Sioofy-Khojine, AB, Richardson, SJ, Locke, JM, Oikarinen, S, Nurminen, N, Laine, AP et al.. Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage. Diabetologia. 2022;65 (10):1701-1709. doi: 10.1007/s00125-022-05753-y. PubMed PMID:35867130 PubMed Central PMC9477938.
  31. Azizi, L, Varela, L, Turkki, P, Mykuliak, VV, Korpela, S, Ihalainen, TO et al.. Talin variant P229S compromises integrin activation and associates with multifaceted clinical symptoms. Hum Mol Genet. 2022;31 (24):4159-4172. doi: 10.1093/hmg/ddac163. PubMed PMID:35861643 PubMed Central PMC9759328.
  32. Lehmusvaara, S, Haikarainen, T, Saarikettu, J, Martinez Nieto, G, Silvennoinen, O. Inhibition of RNA Binding in SND1 Increases the Levels of miR-1-3p and Sensitizes Cancer Cells to Navitoclax. Cancers (Basel). 2022;14 (13):. doi: 10.3390/cancers14133100. PubMed PMID:35804872 PubMed Central PMC9265050.
  33. Laajala, E, Kalim, UU, Grönroos, T, Rasool, O, Halla-Aho, V, Konki, M et al.. Umbilical cord blood DNA methylation in children who later develop type 1 diabetes. Diabetologia. 2022;65 (9):1534-1540. doi: 10.1007/s00125-022-05726-1. PubMed PMID:35716175 PubMed Central PMC9345803.
  34. Zolfaghari Emameh, R, Barker, HR, Turpeinen, H, Parkkila, S, Hytönen, VP. A reverse vaccinology approach on transmembrane carbonic anhydrases from Plasmodium species as vaccine candidates for malaria prevention. Malar J. 2022;21 (1):189. doi: 10.1186/s12936-022-04186-7. PubMed PMID:35706028 PubMed Central PMC9199335.
  35. Laiho, JE, Laitinen, OH, Malkamäki, J, Puustinen, L, Sinkkonen, A, Pärkkä, J et al.. Exposomic determinants of immune-mediated diseases: Special focus on type 1 diabetes, celiac disease, asthma, and allergies: The HEDIMED project approach. Environ Epidemiol. 2022;6 (3):e212. doi: 10.1097/EE9.0000000000000212. PubMed PMID:35702504 PubMed Central PMC9187189.
  36. Niinistö, S, Miettinen, ME, Cuthbertson, D, Honkanen, J, Hakola, L, Autio, R et al.. Associations Between Serum Fatty Acids and Immunological Markers in Children Developing Islet Autoimmunity-The TRIGR Nested Case-Control Study. Front Immunol. 2022;13 :858875. doi: 10.3389/fimmu.2022.858875. PubMed PMID:35693790 PubMed Central PMC9175567.
  37. Urbański, LJ, Bua, S, Angeli, A, Emameh, RZ, Barker, HR, Kuuslahti, M et al.. The production and biochemical characterization of α-carbonic anhydrase from Lactobacillus rhamnosus GG. Appl Microbiol Biotechnol. 2022;106 (11):4065-4074. doi: 10.1007/s00253-022-11990-3. PubMed PMID:35612631 PubMed Central PMC9200688.
  38. Samanta, S, Ylä-Outinen, L, Rangasami, VK, Narkilahti, S, Oommen, OP. Corrigendum to ‘Bidirectional cell-matrix interaction dictates neuronal network formation in a brain mimetic 3D scaffold’ [Acta Biomaterialia (2022) 314-323]. Acta Biomater. 2022;147 :439. doi: 10.1016/j.actbio.2022.05.025. PubMed PMID:35597769 .
  39. Niemelä, T, Kankaanranta, H, Vähätalo, I, Loponen, J, Tuomisto, LE, Niemelä, O et al.. Relationship Between Soluble Urokinase Plasminogen Activator Receptor (suPAR) and Disease Outcome in Adult-Onset Asthma. J Asthma Allergy. 2022;15 :579-593. doi: 10.2147/JAA.S356083. PubMed PMID:35592386 PubMed Central PMC9112192.
  40. Kopra, K, Hassan, N, Vuorinen, E, Valtonen, S, Mahran, R, Habib, H et al.. Rapid high-throughput compatible label-free virus particle quantification method based on time-resolved luminescence. Anal Bioanal Chem. 2022;414 (15):4509-4518. doi: 10.1007/s00216-022-04104-5. PubMed PMID:35581427 PubMed Central PMC9113738.
  41. Välikangas, T, Lietzén, N, Jaakkola, MK, Krogvold, L, Eike, MC, Kallionpää, H et al.. Pancreas Whole Tissue Transcriptomics Highlights the Role of the Exocrine Pancreas in Patients With Recently Diagnosed Type 1 Diabetes. Front Endocrinol (Lausanne). 2022;13 :861985. doi: 10.3389/fendo.2022.861985. PubMed PMID:35498413 PubMed Central PMC9044038.
  42. Tiensuu, H, Haapalainen, AM, Tissarinen, P, Pasanen, A, Määttä, TA, Huusko, JM et al.. Human placental proteomics and exon variant studies link AAT/SERPINA1 with spontaneous preterm birth. BMC Med. 2022;20 (1):141. doi: 10.1186/s12916-022-02339-8. PubMed PMID:35477570 PubMed Central PMC9047282.
  43. Knuf, M, Rämet, M, Breinholt Stærke, N, Bertrand-Gerentes, I, Thollot, Y, B’Chir, S et al.. Comparing the meningococcal serogroup C immune response elicited by a tetanus toxoid conjugate quadrivalent meningococcal vaccine (MenACYW-TT) versus a quadrivalent or monovalent C tetanus toxoid conjugate meningococcal vaccine in healthy meningococcal vaccine-naïve toddlers: A randomised, controlled trial. Hum Vaccin Immunother. 2022;18 (5):2052657. doi: 10.1080/21645515.2022.2052657. PubMed PMID:35445641 PubMed Central PMC9225511.
  44. Soininen, L, Roslund, MI, Nurminen, N, Puhakka, R, Laitinen, OH, Hyöty, H et al.. Indoor green wall affects health-associated commensal skin microbiota and enhances immune regulation: a randomized trial among urban office workers. Sci Rep. 2022;12 (1):6518. doi: 10.1038/s41598-022-10432-4. PubMed PMID:35444249 PubMed Central PMC9021224.
  45. Piesanen, J, Valjakka, J, Niemelä, S, Borgenström, M, Nikkari, S, Hytönen, V et al.. Hepcidin is potential regulator for renin activity. PLoS One. 2022;17 (4):e0267343. doi: 10.1371/journal.pone.0267343. PubMed PMID:35442992 PubMed Central PMC9020709.
  46. Lehtola, T, Nummenmaa, E, Tuure, L, Hämäläinen, M, Nieminen, RM, Moilanen, T et al.. Dexamethasone Attenuates the Expression of MMP-13 in Chondrocytes through MKP-1. Int J Mol Sci. 2022;23 (7):. doi: 10.3390/ijms23073880. PubMed PMID:35409238 PubMed Central PMC8998740.
  47. Hård Af Segerstad, EM, Liu, X, Uusitalo, U, Agardh, D, Andrén Aronsson, C, TEDDY Study Group et al.. Sources of dietary gluten in the first 2 years of life and associations with celiac disease autoimmunity and celiac disease in Swedish genetically predisposed children: The Environmental Determinants of Diabetes in the Young (TEDDY) study. Am J Clin Nutr. 2022;116 (2):394-403. doi: 10.1093/ajcn/nqac086. PubMed PMID:35394004 PubMed Central PMC9348971.
  48. Lindfors, L, Sioris, P, Anttalainen, A, Korelin, K, Kontunen, A, Karjalainen, M et al.. Detection of cultured breast cancer cells from human tumor-derived matrix by differential ion mobility spectrometry. Anal Chim Acta. 2022;1202 :339659. doi: 10.1016/j.aca.2022.339659. PubMed PMID:35341512 .
  49. Törn, C, Liu, X, Onengut-Gumuscu, S, Counts, KM, Moreno, JL, Remedios, CL et al.. Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study. Sci Rep. 2022;12 (1):4516. doi: 10.1038/s41598-022-08058-7. PubMed PMID:35296692 PubMed Central PMC8927592.
  50. Li, Z, Veijola, R, Koski, E, Anand, V, Martin, F, Waugh, K et al.. Childhood Height Growth Rate Association With the Risk of Islet Autoimmunity and Development of Type 1 Diabetes. J Clin Endocrinol Metab. 2022;107 (6):1520-1528. doi: 10.1210/clinem/dgac121. PubMed PMID:35244713 PubMed Central PMC9113806.
  51. Domachowske, J, Madhi, SA, Simões, EAF, Atanasova, V, Cabañas, F, Furuno, K et al.. Safety of Nirsevimab for RSV in Infants with Heart or Lung Disease or Prematurity. N Engl J Med. 2022;386 (9):892-894. doi: 10.1056/NEJMc2112186. PubMed PMID:35235733 .
  52. Hammitt, LL, Dagan, R, Yuan, Y, Baca Cots, M, Bosheva, M, Madhi, SA et al.. Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants. N Engl J Med. 2022;386 (9):837-846. doi: 10.1056/NEJMoa2110275. PubMed PMID:35235726 .
  53. Archer, M, Niemelä, O, Hämäläinen, M, Moilanen, E, Leinonen, E, Kampman, O et al.. The role of alcohol use and adiposity in serum levels of IL-1RA in depressed patients. BMC Psychiatry. 2022;22 (1):158. doi: 10.1186/s12888-022-03784-8. PubMed PMID:35232419 PubMed Central PMC8889691.
  54. Ferrat, LA, Vehik, K, Sharp, SA, Lernmark, Å, Rewers, MJ, She, JX et al.. Author Correction: A combined risk score enhances prediction of type 1 diabetes among susceptible children. Nat Med. 2022;28 (3):599. doi: 10.1038/s41591-021-01631-z. PubMed PMID:35165454 .
  55. Suomi, T, Kalim, UU, Rasool, O, Laiho, A, Kallionpää, H, Vähä-Mäkilä, M et al.. Type 1 Diabetes in Children With Genetic Risk May Be Predicted Very Early With a Blood miRNA. Diabetes Care. 2022;45 (4):e77-e79. doi: 10.2337/dc21-2120. PubMed PMID:35134118 PubMed Central PMC9016735.
  56. Samanta, S, Rangasami, VK, Sarlus, H, Samal, JRK, Evans, AD, Parihar, VS et al.. Interpenetrating gallol functionalized tissue adhesive hyaluronic acid hydrogel polarizes macrophages to an immunosuppressive phenotype. Acta Biomater. 2022;142 :36-48. doi: 10.1016/j.actbio.2022.01.048. PubMed PMID:35085799 .
  57. Tusé, D, Malm, M, Tamminen, K, Diessner, A, Thieme, F, Jarczowski, F et al.. Safety and immunogenicity studies in animal models support clinical development of a bivalent norovirus-like particle vaccine produced in plants. Vaccine. 2022;40 (7):977-987. doi: 10.1016/j.vaccine.2022.01.009. PubMed PMID:35063285 .
  58. Jacobsen, LM, Vehik, K, Veijola, R, Warncke, K, Toppari, J, Steck, AK et al.. Heterogeneity of DKA Incidence and Age-Specific Clinical Characteristics in Children Diagnosed With Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2022;45 (3):624-633. doi: 10.2337/dc21-0422. PubMed PMID:35043162 PubMed Central PMC8918232.
  59. Buchacher, T, Honkimaa, A, Välikangas, T, Lietzén, N, Hirvonen, MK, Laiho, JE et al.. Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells. iScience. 2022;25 (1):103653. doi: 10.1016/j.isci.2021.103653. PubMed PMID:35024587 PubMed Central PMC8728469.
  60. Melin, J, Lynch, KF, Lundgren, M, Aronsson, CA, Larsson, HE, Johnson, SB et al.. Is staff consistency important to parents’ satisfaction in a longitudinal study of children at risk for type 1 diabetes: the TEDDY study. BMC Endocr Disord. 2022;22 (1):19. doi: 10.1186/s12902-021-00929-w. PubMed PMID:35012530 PubMed Central PMC8744326.
  61. Samanta, S, Ylä-Outinen, L, Rangasami, VK, Narkilahti, S, Oommen, OP. Bidirectional cell-matrix interaction dictates neuronal network formation in a brain-mimetic 3D scaffold. Acta Biomater. 2022;140 :314-323. doi: 10.1016/j.actbio.2021.12.010. PubMed PMID:34902615 .
  62. Heinimäki, S, Lampinen, V, Tamminen, K, Hankaniemi, MM, Malm, M, Hytönen, VP et al.. Antigenicity and immunogenicity of HA2 and M2e influenza virus antigens conjugated to norovirus-like, VP1 capsid-based particles by the SpyTag/SpyCatcher technology. Virology. 2022;566 :89-97. doi: 10.1016/j.virol.2021.12.001. PubMed PMID:34894525 .
  63. González-Rodríguez, MI, Nurminen, N, Kummola, L, Laitinen, OH, Oikarinen, S, Parajuli, A et al.. Effect of inactivated nature-derived microbial composition on mouse immune system. Immun Inflamm Dis. 2022;10 (3):e579. doi: 10.1002/iid3.579. PubMed PMID:34873877 PubMed Central PMC8926502.
  64. Salomaa, T, Pemmari, T, Määttä, J, Kummola, L, Salonen, N, González-Rodríguez, M et al.. IL-13Rα1 Suppresses Tumor Progression in Two-Stage Skin Carcinogenesis Model by Regulating Regulatory T Cells. J Invest Dermatol. 2022;142 (6):1565-1575.e17. doi: 10.1016/j.jid.2021.11.013. PubMed PMID:34808240 .
  65. Walter, EB, Talaat, KR, Sabharwal, C, Gurtman, A, Lockhart, S, Paulsen, GC et al.. Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age. N Engl J Med. 2022;386 (1):35-46. doi: 10.1056/NEJMoa2116298. PubMed PMID:34752019 PubMed Central PMC8609605.
  66. Urbański, LJ, Angeli, A, Mykuliak, VV, Azizi, L, Kuuslahti, M, Hytönen, VP et al.. Biochemical and structural characterization of beta-carbonic anhydrase from the parasite Trichomonas vaginalis. J Mol Med (Berl). 2022;100 (1):115-124. doi: 10.1007/s00109-021-02148-1. PubMed PMID:34652457 PubMed Central PMC8724216.

Search PubMed